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The map label for this gene is kynU [H]

Identifier: 229917228

GI number: 229917228

Start: 1468843

End: 1470117

Strand: Direct

Name: kynU [H]

Synonym: EAT1b_1503

Alternate gene names: 229917228

Gene position: 1468843-1470117 (Clockwise)

Preceding gene: 229917225

Following gene: 229917229

Centisome position: 48.96

GC content: 52.55

Gene sequence:

>1275_bases
ATGAACGATTTCACACGTGCTTACGTACAACAACTAGACAAACAAGACCCGCTCGCATCGTATCGGGAAGAATTTTATTT
ACCGGAACACGGGATTTATATGGATGGGAATTCACTCGGTCTCTTATCGAAACGAGCCGAGCGCACACTCCTTGAATCAC
TTGCGGACTGGAGAGAGCTCGGGATCGACGGCTGGATGTCAGGTCGCCATCCTTGGTTCAACTTGTCCGAAGAGTTGGCC
GCACTGAACGCGCCGCTCATCGGTGGAAAGCCGGAAGAAGTGATGGTCACTGGTTCGACGACCGTGAACTTGCATCAACT
CGTCGCATCGTTCTTCAAACCGGATGGCAAACGCACGAAGATTTTGGCAGACGCCCTCACGTTCCCGTCTGACATTTACG
CTTTAAAGAGCCAGCTCGAATTGCGTGGACTCGACCCTTCTGAGCACCTCGTTCAAGTCGACAGTCCGGATGGGCGCTTC
TTGGTAGAAGACGACTTGATTGCCGCGATGACCGACGAGATTGCCCTGATCGTATTGCCGACCGTCCTCTATCGGAGTGG
TCAGATTTTAGATATGCCTCGTCTAACGAAGGCGGCACACGAGCGTGGAATTTTGATTGGCTTCGATGCCTGTCACTCCG
TCGGCGCCATTCCTCATGACTTCCACGACTGGGGTGTCGACTTCGCATACTGGTGCAACTATAAACATTTGAACGGGGGT
CCAGGAACGGTCGGGGGCTTATTTGTTCATAAACGTCACTTCGGCACGACACCTGGACTCGCCGGTTGGTTCGGTTCGCG
CAAAGATAAGCAATTCGATATGGACCATACGATGACACCAGCCGAACATGCCGGTGCGTTCCAAATCGGAACACCACACG
TTATGAGCCTCGCTCCTCAACTTGGTGCGCTTGAGATGTTCAACGAGGTCGGGATGGAAGCGATTCGTCAAAAATCACTC
GCGCTCACGACGTATATGATGGATTTGATCGAAGAGATGCTCGCACCTCACGGATTCTTCATCGGTAGCCCGACTGACAC
ACGACAGCGCGGCGCTCATTTGAGCCTCGAGCATCCTGAAGCGGCACGCATCTGTAAAGCGTTGAAGAAACATCACATCA
TCCCTGACTTCCGCGCACCGAATATCATCCGTCTCGCGCCGGTCGCACTATATAATACGTTTACCGACGTATATGACGTG
ATCGTGACGTTGAAGCAAATCATGGACAACAAAGAGTACGAGGCGTTCGAGAACGTCCGCGAAGTGGTCGCATAA

Upstream 100 bases:

>100_bases
TGTGTATGATGTCTACCTGCCCTCGTTGTTTGTTGACTTCCTTATGTCCGATTGCTACGATTTTGACAACGTACAAGCTT
TAAAGGGGGAATATGGGGAG

Downstream 100 bases:

>100_bases
GGGGGAACTGTCATGAGTGAACGCACGGAACATAAAGTAGAAAAATCGATTCAAACGGACTTTTCAAAAGACATGTCGTA
CGGGGACTATCTCCAGCTCG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNDFTRAYVQQLDKQDPLASYREEFYLPEHGIYMDGNSLGLLSKRAERTLLESLADWRELGIDGWMSGRHPWFNLSEELA
ALNAPLIGGKPEEVMVTGSTTVNLHQLVASFFKPDGKRTKILADALTFPSDIYALKSQLELRGLDPSEHLVQVDSPDGRF
LVEDDLIAAMTDEIALIVLPTVLYRSGQILDMPRLTKAAHERGILIGFDACHSVGAIPHDFHDWGVDFAYWCNYKHLNGG
PGTVGGLFVHKRHFGTTPGLAGWFGSRKDKQFDMDHTMTPAEHAGAFQIGTPHVMSLAPQLGALEMFNEVGMEAIRQKSL
ALTTYMMDLIEEMLAPHGFFIGSPTDTRQRGAHLSLEHPEAARICKALKKHHIIPDFRAPNIIRLAPVALYNTFTDVYDV
IVTLKQIMDNKEYEAFENVREVVA

Sequences:

>Translated_424_residues
MNDFTRAYVQQLDKQDPLASYREEFYLPEHGIYMDGNSLGLLSKRAERTLLESLADWRELGIDGWMSGRHPWFNLSEELA
ALNAPLIGGKPEEVMVTGSTTVNLHQLVASFFKPDGKRTKILADALTFPSDIYALKSQLELRGLDPSEHLVQVDSPDGRF
LVEDDLIAAMTDEIALIVLPTVLYRSGQILDMPRLTKAAHERGILIGFDACHSVGAIPHDFHDWGVDFAYWCNYKHLNGG
PGTVGGLFVHKRHFGTTPGLAGWFGSRKDKQFDMDHTMTPAEHAGAFQIGTPHVMSLAPQLGALEMFNEVGMEAIRQKSL
ALTTYMMDLIEEMLAPHGFFIGSPTDTRQRGAHLSLEHPEAARICKALKKHHIIPDFRAPNIIRLAPVALYNTFTDVYDV
IVTLKQIMDNKEYEAFENVREVVA
>Mature_424_residues
MNDFTRAYVQQLDKQDPLASYREEFYLPEHGIYMDGNSLGLLSKRAERTLLESLADWRELGIDGWMSGRHPWFNLSEELA
ALNAPLIGGKPEEVMVTGSTTVNLHQLVASFFKPDGKRTKILADALTFPSDIYALKSQLELRGLDPSEHLVQVDSPDGRF
LVEDDLIAAMTDEIALIVLPTVLYRSGQILDMPRLTKAAHERGILIGFDACHSVGAIPHDFHDWGVDFAYWCNYKHLNGG
PGTVGGLFVHKRHFGTTPGLAGWFGSRKDKQFDMDHTMTPAEHAGAFQIGTPHVMSLAPQLGALEMFNEVGMEAIRQKSL
ALTTYMMDLIEEMLAPHGFFIGSPTDTRQRGAHLSLEHPEAARICKALKKHHIIPDFRAPNIIRLAPVALYNTFTDVYDV
IVTLKQIMDNKEYEAFENVREVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=431, Percent_Identity=36.1948955916473, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI74101437, Length=276, Percent_Identity=38.4057971014493, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17550466, Length=431, Percent_Identity=34.5707656612529, Blast_Score=262, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6323261, Length=448, Percent_Identity=36.3839285714286, Blast_Score=267, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 47441; Mature: 47441

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFTRAYVQQLDKQDPLASYREEFYLPEHGIYMDGNSLGLLSKRAERTLLESLADWREL
CCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
GIDGWMSGRHPWFNLSEELAALNAPLIGGKPEEVMVTGSTTVNLHQLVASFFKPDGKRTK
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHH
ILADALTFPSDIYALKSQLELRGLDPSEHLVQVDSPDGRFLVEDDLIAAMTDEIALIVLP
HHHHHHCCCHHHHHHHHHHHHCCCCCHHCEEEEECCCCCEEECCCHHHHHHHHHHHHHHH
TVLYRSGQILDMPRLTKAAHERGILIGFDACHSVGAIPHDFHDWGVDFAYWCNYKHLNGG
HHHHCCCCEECCHHHHHHHHHCCEEEEEHHHHHCCCCCCCHHHHCCCEEEEECCCCCCCC
PGTVGGLFVHKRHFGTTPGLAGWFGSRKDKQFDMDHTMTPAEHAGAFQIGTPHVMSLAPQ
CCCHHHHEEEHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHCCEEECCCCHHHHHCCH
LGALEMFNEVGMEAIRQKSLALTTYMMDLIEEMLAPHGFFIGSPTDTRQRGAHLSLEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCEECCCCCH
AARICKALKKHHIIPDFRAPNIIRLAPVALYNTFTDVYDVIVTLKQIMDNKEYEAFENVR
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EVVA
HHHC
>Mature Secondary Structure
MNDFTRAYVQQLDKQDPLASYREEFYLPEHGIYMDGNSLGLLSKRAERTLLESLADWREL
CCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
GIDGWMSGRHPWFNLSEELAALNAPLIGGKPEEVMVTGSTTVNLHQLVASFFKPDGKRTK
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHH
ILADALTFPSDIYALKSQLELRGLDPSEHLVQVDSPDGRFLVEDDLIAAMTDEIALIVLP
HHHHHHCCCHHHHHHHHHHHHCCCCCHHCEEEEECCCCCEEECCCHHHHHHHHHHHHHHH
TVLYRSGQILDMPRLTKAAHERGILIGFDACHSVGAIPHDFHDWGVDFAYWCNYKHLNGG
HHHHCCCCEECCHHHHHHHHHCCEEEEEHHHHHCCCCCCCHHHHCCCEEEEECCCCCCCC
PGTVGGLFVHKRHFGTTPGLAGWFGSRKDKQFDMDHTMTPAEHAGAFQIGTPHVMSLAPQ
CCCHHHHEEEHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHCCEEECCCCHHHHHCCH
LGALEMFNEVGMEAIRQKSLALTTYMMDLIEEMLAPHGFFIGSPTDTRQRGAHLSLEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCEECCCCCH
AARICKALKKHHIIPDFRAPNIIRLAPVALYNTFTDVYDVIVTLKQIMDNKEYEAFENVR
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EVVA
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA