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The map label for this gene is kynA [H]

Identifier: 229917229

GI number: 229917229

Start: 1470130

End: 1470969

Strand: Direct

Name: kynA [H]

Synonym: EAT1b_1504

Alternate gene names: 229917229

Gene position: 1470130-1470969 (Clockwise)

Preceding gene: 229917228

Following gene: 229917230

Centisome position: 49.01

GC content: 50.95

Gene sequence:

>840_bases
ATGAGTGAACGCACGGAACATAAAGTAGAAAAATCGATTCAAACGGACTTTTCAAAAGACATGTCGTACGGGGACTATCT
CCAGCTCGACCCGATTTTATCGAGTCAGCATCGCCTTTCCGACCATCACGATGAGATGCTGTTCATCATCATCCATCAGA
CGAGCGAGTTGTGGATGAAACTCATTTTGCATGAATTGACAGCAGCCACGACGGCCATCACGAACGGCGAACTCGAACGT
TCGTTCAAGATGCTCGCCCGCGTCTCGAAGATTCAGCAACAACTCATCCAGTCATGGGGCGTCCTCGCGACGTTGACGCC
GGCCGAGTATTTAGAGTTCCGAGACCAACTCGGCTCGTCCTCTGGTTTTCAGTCTTACCAGAACCGACAAATCGAATTCG
CACTCGGCTTCAAAAACGCACGGACGCTCAGTGTTTACGCACACGATGAAAAATTGTATCCATTGCTCGAAGGCTCGCTA
CAAGCTCCTAGCATTTATGATGTGACGGTCCGCGAAATGCATCGTCGGGGTCTATCGATTGATGCGAGCGTGCTCGAACG
TGATGTCACCCAGGACTGGGAATGGAATGAAAGTGTCGAGAAGGCATGGGTCGAAGTCTATCGAGACGTCGATACGTATT
GGGACTTATATGAGCTCGGTGAAAAGCTACTCGATATCGGGAGCCAGCAACAGATGTGGCGCTTTAACCATATGAGCACC
GTGGAACGCATTATCGGACAGAAGATGGGGACAGGCGGCTCGTCTGGCGTGAACTATTTACGTCGCGTGCTCGACCATCG
CTTCTTCCCAGAACTGTGGACGGTCCGGACATCACTATAA

Upstream 100 bases:

>100_bases
CGTATATGACGTGATCGTGACGTTGAAGCAAATCATGGACAACAAAGAGTACGAGGCGTTCGAGAACGTCCGCGAAGTGG
TCGCATAAGGGGGAACTGTC

Downstream 100 bases:

>100_bases
GAGGAGCTGAATGCAATGACTTGGATTGATGTATCACAGCCACTCCATGCCGATGTTGCGACATGGCCGGGAGATACAAA
ATTTTCGTATGATATCGCGT

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MSERTEHKVEKSIQTDFSKDMSYGDYLQLDPILSSQHRLSDHHDEMLFIIIHQTSELWMKLILHELTAATTAITNGELER
SFKMLARVSKIQQQLIQSWGVLATLTPAEYLEFRDQLGSSSGFQSYQNRQIEFALGFKNARTLSVYAHDEKLYPLLEGSL
QAPSIYDVTVREMHRRGLSIDASVLERDVTQDWEWNESVEKAWVEVYRDVDTYWDLYELGEKLLDIGSQQQMWRFNHMST
VERIIGQKMGTGGSSGVNYLRRVLDHRFFPELWTVRTSL

Sequences:

>Translated_279_residues
MSERTEHKVEKSIQTDFSKDMSYGDYLQLDPILSSQHRLSDHHDEMLFIIIHQTSELWMKLILHELTAATTAITNGELER
SFKMLARVSKIQQQLIQSWGVLATLTPAEYLEFRDQLGSSSGFQSYQNRQIEFALGFKNARTLSVYAHDEKLYPLLEGSL
QAPSIYDVTVREMHRRGLSIDASVLERDVTQDWEWNESVEKAWVEVYRDVDTYWDLYELGEKLLDIGSQQQMWRFNHMST
VERIIGQKMGTGGSSGVNYLRRVLDHRFFPELWTVRTSL
>Mature_278_residues
SERTEHKVEKSIQTDFSKDMSYGDYLQLDPILSSQHRLSDHHDEMLFIIIHQTSELWMKLILHELTAATTAITNGELERS
FKMLARVSKIQQQLIQSWGVLATLTPAEYLEFRDQLGSSSGFQSYQNRQIEFALGFKNARTLSVYAHDEKLYPLLEGSLQ
APSIYDVTVREMHRRGLSIDASVLERDVTQDWEWNESVEKAWVEVYRDVDTYWDLYELGEKLLDIGSQQQMWRFNHMSTV
ERIIGQKMGTGGSSGVNYLRRVLDHRFFPELWTVRTSL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=149, Percent_Identity=36.241610738255, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32564651, Length=202, Percent_Identity=30.6930693069307, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17552370, Length=223, Percent_Identity=29.1479820627803, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17530891, Length=335, Percent_Identity=31.044776119403, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 32547; Mature: 32416

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERTEHKVEKSIQTDFSKDMSYGDYLQLDPILSSQHRLSDHHDEMLFIIIHQTSELWMK
CCCHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCCEEEEEEECCHHHHHH
LILHELTAATTAITNGELERSFKMLARVSKIQQQLIQSWGVLATLTPAEYLEFRDQLGSS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
SGFQSYQNRQIEFALGFKNARTLSVYAHDEKLYPLLEGSLQAPSIYDVTVREMHRRGLSI
CCHHHHHCCEEEEEEECCCCEEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCC
DASVLERDVTQDWEWNESVEKAWVEVYRDVDTYWDLYELGEKLLDIGSQQQMWRFNHMST
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VERIIGQKMGTGGSSGVNYLRRVLDHRFFPELWTVRTSL
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
SERTEHKVEKSIQTDFSKDMSYGDYLQLDPILSSQHRLSDHHDEMLFIIIHQTSELWMK
CCHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCCEEEEEEECCHHHHHH
LILHELTAATTAITNGELERSFKMLARVSKIQQQLIQSWGVLATLTPAEYLEFRDQLGSS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
SGFQSYQNRQIEFALGFKNARTLSVYAHDEKLYPLLEGSLQAPSIYDVTVREMHRRGLSI
CCHHHHHCCEEEEEEECCCCEEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCC
DASVLERDVTQDWEWNESVEKAWVEVYRDVDTYWDLYELGEKLLDIGSQQQMWRFNHMST
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VERIIGQKMGTGGSSGVNYLRRVLDHRFFPELWTVRTSL
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA