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The map label for this gene is yclK [H]

Identifier: 229916986

GI number: 229916986

Start: 1233070

End: 1234479

Strand: Direct

Name: yclK [H]

Synonym: EAT1b_1260

Alternate gene names: 229916986

Gene position: 1233070-1234479 (Clockwise)

Preceding gene: 229916985

Following gene: 229916989

Centisome position: 41.1

GC content: 48.01

Gene sequence:

>1410_bases
ATGAAGCGAGGTCGTAACAGTCTACCGTTTCGCATCAGCCTCGTCTTCCTGTTGTCTACGTTGTTGATTGAAGGAGTCTT
ATTCTTACTCCTTTACCACACACTACTTGGGGAACGCGTGACAGAAGAAATCCATCGATTAGAATCCCGGGCTGAGAGTC
ATGCGACTGTATTGGCGATGAACTTTTCCGAAGAGACAATCGGTCATGTGGCTACCATGGAAAGTGAAACGGACACAAAA
GTTGCCATCACCGATCCAGCACATGATCTTCTTCAAACTTCCCGTTCTTTTCCACAGGTACTAGTCGATACCGTCGAGAC
GAAACGACGTACGGGTCCCTTCGATGACACGACTATTCTAGAGGACGACTGGGAGAACGAGCCGTATTTGAGCGTGCGTA
CGCCAATCACAGATGATTTCGATACACGGTATGGATATGTCTACATGTTTTTACCGACTGAAATCATTCATGGAATCAGT
CATCGCCTTCAGTTGCGATTTCTGTACATCACGGCCATCGCACTGGTGACGACCGTGTTGACCTTCATCCTGCTGAGCCG
CCTCATTTCGAAACCAATTCAGTCACTGAAACAAGCGACCGAGAACGTACTGACAAACCCCGAAAACCTACAGCTACCAA
CGAATCGCGTTGACGAAATCGGTGAGTTGGCTCGCTCCATAGAAGCCATGTCTGTGGAGTTGGCTCGTTTACGTCGCGAA
CGACATCAATTTTTGTCCGATCTCTCACATGAAATCAAGACCCCTCTCACTTATTTGAGAGGATATGCCGAGATCGCTTC
AAAAGAAAGCACACCCGAACCGCTACGCAATCAATCCATCCAGACAATCTTAGATGAGAGTCGCTCGCTCACAGAACTGG
TGGAAAATGCGTTTCAATTGGCTCAACTCGACGAAAACACGTTTTTGTTACATCGAGAAGAAGTGACTGTCACGACGTTT
TGTGCGGATTTACGACGAATGCTCGATACGATGTTCCGAATGACAACGATTCGGTTCGTCCCTTCTCCAATCATAGAACA
AGCAGATATCGCTCTCACATTGGATCGACATCGGATGCTTCAGGTCTTTCGGTCCATTGCCCACAACGCGATTCAGCATA
GTGAGGCGACACATGTTTCACTTCATTCTACTACTTCAGACGCTTATCTCGTCTTGACCATCACTGACGACGGAAAAGGA
ATTCCCAAAGAAGATCTCCCACACATTTTCGACCGTCTGTACCGTGTTGAAAAATCACGATCTCGTCAAACTGGTGGAAG
CGGACTCGGACTCGCCATCGCCAAGCAAATCGTTACACGTCATGGTGGGACGTTGACGGTATCTTCGGATACAACAGGTA
CCTCGTTCACCGTCACCCTACCACTCGGTAAAAAGACGCCTCTCCAGTAA

Upstream 100 bases:

>100_bases
GTATGATTCGAGAAAAGTTAGGCGATGCAGGATTCCCGATTGATGATTATTTAAAGACGGTATGGGGACGTGGCTATCGA
TGGACCGAGGAGCGTTCCGG

Downstream 100 bases:

>100_bases
TGGAAAGGCGTCTTTCGTCAGTCGAGTTCACCTGCATCAAGTTGTGTCTGCCACTCCTCGTCTATGAACTCATATACGCT
GTTATCCGATGTGACAAGCA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKRGRNSLPFRISLVFLLSTLLIEGVLFLLLYHTLLGERVTEEIHRLESRAESHATVLAMNFSEETIGHVATMESETDTK
VAITDPAHDLLQTSRSFPQVLVDTVETKRRTGPFDDTTILEDDWENEPYLSVRTPITDDFDTRYGYVYMFLPTEIIHGIS
HRLQLRFLYITAIALVTTVLTFILLSRLISKPIQSLKQATENVLTNPENLQLPTNRVDEIGELARSIEAMSVELARLRRE
RHQFLSDLSHEIKTPLTYLRGYAEIASKESTPEPLRNQSIQTILDESRSLTELVENAFQLAQLDENTFLLHREEVTVTTF
CADLRRMLDTMFRMTTIRFVPSPIIEQADIALTLDRHRMLQVFRSIAHNAIQHSEATHVSLHSTTSDAYLVLTITDDGKG
IPKEDLPHIFDRLYRVEKSRSRQTGGSGLGLAIAKQIVTRHGGTLTVSSDTTGTSFTVTLPLGKKTPLQ

Sequences:

>Translated_469_residues
MKRGRNSLPFRISLVFLLSTLLIEGVLFLLLYHTLLGERVTEEIHRLESRAESHATVLAMNFSEETIGHVATMESETDTK
VAITDPAHDLLQTSRSFPQVLVDTVETKRRTGPFDDTTILEDDWENEPYLSVRTPITDDFDTRYGYVYMFLPTEIIHGIS
HRLQLRFLYITAIALVTTVLTFILLSRLISKPIQSLKQATENVLTNPENLQLPTNRVDEIGELARSIEAMSVELARLRRE
RHQFLSDLSHEIKTPLTYLRGYAEIASKESTPEPLRNQSIQTILDESRSLTELVENAFQLAQLDENTFLLHREEVTVTTF
CADLRRMLDTMFRMTTIRFVPSPIIEQADIALTLDRHRMLQVFRSIAHNAIQHSEATHVSLHSTTSDAYLVLTITDDGKG
IPKEDLPHIFDRLYRVEKSRSRQTGGSGLGLAIAKQIVTRHGGTLTVSSDTTGTSFTVTLPLGKKTPLQ
>Mature_469_residues
MKRGRNSLPFRISLVFLLSTLLIEGVLFLLLYHTLLGERVTEEIHRLESRAESHATVLAMNFSEETIGHVATMESETDTK
VAITDPAHDLLQTSRSFPQVLVDTVETKRRTGPFDDTTILEDDWENEPYLSVRTPITDDFDTRYGYVYMFLPTEIIHGIS
HRLQLRFLYITAIALVTTVLTFILLSRLISKPIQSLKQATENVLTNPENLQLPTNRVDEIGELARSIEAMSVELARLRRE
RHQFLSDLSHEIKTPLTYLRGYAEIASKESTPEPLRNQSIQTILDESRSLTELVENAFQLAQLDENTFLLHREEVTVTTF
CADLRRMLDTMFRMTTIRFVPSPIIEQADIALTLDRHRMLQVFRSIAHNAIQHSEATHVSLHSTTSDAYLVLTITDDGKG
IPKEDLPHIFDRLYRVEKSRSRQTGGSGLGLAIAKQIVTRHGGTLTVSSDTTGTSFTVTLPLGKKTPLQ

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=29.4736842105263, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=29.4871794871795, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=27.8523489932886, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787894, Length=313, Percent_Identity=27.7955271565495, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=30.5785123966942, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=320, Percent_Identity=25.3125, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790861, Length=332, Percent_Identity=25.6024096385542, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=26.4069264069264, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790346, Length=289, Percent_Identity=25.2595155709343, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=22.8682170542636, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=24.2063492063492, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=356, Percent_Identity=24.1573033707865, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=26.4957264957265, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=24.3362831858407, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=312, Percent_Identity=24.0384615384615, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=23.7903225806452, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=311, Percent_Identity=24.1157556270096, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789403, Length=369, Percent_Identity=21.9512195121951, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53136; Mature: 53136

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGRNSLPFRISLVFLLSTLLIEGVLFLLLYHTLLGERVTEEIHRLESRAESHATVLAM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NFSEETIGHVATMESETDTKVAITDPAHDLLQTSRSFPQVLVDTVETKRRTGPFDDTTIL
ECCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEE
EDDWENEPYLSVRTPITDDFDTRYGYVYMFLPTEIIHGISHRLQLRFLYITAIALVTTVL
CCCCCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFILLSRLISKPIQSLKQATENVLTNPENLQLPTNRVDEIGELARSIEAMSVELARLRRE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHQFLSDLSHEIKTPLTYLRGYAEIASKESTPEPLRNQSIQTILDESRSLTELVENAFQL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
AQLDENTFLLHREEVTVTTFCADLRRMLDTMFRMTTIRFVPSPIIEQADIALTLDRHRML
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEHHHHHHH
QVFRSIAHNAIQHSEATHVSLHSTTSDAYLVLTITDDGKGIPKEDLPHIFDRLYRVEKSR
HHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
SRQTGGSGLGLAIAKQIVTRHGGTLTVSSDTTGTSFTVTLPLGKKTPLQ
CCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MKRGRNSLPFRISLVFLLSTLLIEGVLFLLLYHTLLGERVTEEIHRLESRAESHATVLAM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NFSEETIGHVATMESETDTKVAITDPAHDLLQTSRSFPQVLVDTVETKRRTGPFDDTTIL
ECCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEE
EDDWENEPYLSVRTPITDDFDTRYGYVYMFLPTEIIHGISHRLQLRFLYITAIALVTTVL
CCCCCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFILLSRLISKPIQSLKQATENVLTNPENLQLPTNRVDEIGELARSIEAMSVELARLRRE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHQFLSDLSHEIKTPLTYLRGYAEIASKESTPEPLRNQSIQTILDESRSLTELVENAFQL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
AQLDENTFLLHREEVTVTTFCADLRRMLDTMFRMTTIRFVPSPIIEQADIALTLDRHRML
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEHHHHHHH
QVFRSIAHNAIQHSEATHVSLHSTTSDAYLVLTITDDGKGIPKEDLPHIFDRLYRVEKSR
HHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
SRQTGGSGLGLAIAKQIVTRHGGTLTVSSDTTGTSFTVTLPLGKKTPLQ
CCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]