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The map label for this gene is mco [H]

Identifier: 229916989

GI number: 229916989

Start: 1237625

End: 1239172

Strand: Direct

Name: mco [H]

Synonym: EAT1b_1263

Alternate gene names: 229916989

Gene position: 1237625-1239172 (Clockwise)

Preceding gene: 229916986

Following gene: 229916990

Centisome position: 41.26

GC content: 49.81

Gene sequence:

>1548_bases
ATGAAGGAGTGTTATAGCATGAAATCGAAAGGCATGTGGTTTCTGTTGACGGGGATTTTAATTGGGGGCATCTTCGTTTT
ACTAGTCGTCCTCTTCAACGGAACATGGAACCATAACAACAATATGGACCAAAATCATATGATGGGACACGATTCGGCAA
CGAGTCAGATGGATGATCACATGATGAGTGATAATGGAATGGATGACAATGACGGACCGATGGGACATGGAGCGATGCAA
GAGCTCCAAGCATCGGATGAACCGACAAAGCCGCTTCCGATTCCGACTGCCTTACAGCCAGATCGTGTCACGGGAGACAC
GGTCTACTATACGGTGGAAGCAACTAAAGGCACGTCACAATTTTTCAAAGACGGCAAGAAATCGGAAACGTTCGGCTATA
ATGGAGACTTACTCGGACCAATGATCGAGTTACCGAAAGGAAAAACAGTCGTAATCGATACCATCAATCGATTGGATGAA
CCGACAACGTTCCACTGGCACGGACTCGTCATCCCTGCCGACATGGACGGGGGACCTCATCAGACCGTCCCACCAGGTGA
ACGGGCACAAGTTCGACTCGACATCGATCAAGAACCTAGTACACTGTGGTTTCACCCCCATCCGATGGGATCGACAGCCG
AACAAGTTTATAAAGGACTCGCCGGTCTTCTTTATGTGACCGACGATGCACAGAACGGTCTCCCGAATGAATATGGAGTC
GACGACATCCCACTCATCGTACAAGATCGACTCTTCACGCCTAACGGTGAGTTGGATTATGATGCCCATATGAACGTTGA
TGGAACGACGGGGGATACCATTCTTGCGAATGGAGCCATCAACACGACGTTCGACGTTCAAACCGAGACGTTACGAGTGC
GACTAGTCAACGGTTCGAATGCGCGTGATTTTGATTTTACGCTATCTAACGAGGCCGAGATGACGCAGATTGCGACAGAC
GGAGGGCCGTTAGAACGCCCGATTCCCTTAGAGACCCTCACGTTGACACCAGGTGAACGGGCCGAGGTACTGATTGATTT
TTCACAAGTTGAAGATGTCGCCGCCTTAAAAGCGGACGGGGTGACATTTACCACGTTTCGTATCGGTGAACTCGACAAGG
CGTCCATTAAGATTCCGACGATTGAAACGGTGGAGCGCTCGACAGATGAGACAGCAGACCGTCGCCTCACCCTTTTTGGA
ATGGGTAACATGGTGTCAATCAACGGAAAGACATATGACCCGGAGCGTATCGACATCGAAGCGAAACGCGGAGACACTGA
GGTATGGGAAATTGAAAATAAGCCGGACATGATGGGTGGGATGACACATCCTTTCCACATCCACGGGGTCCAGTTCCGAG
TCATCAGTCGAGACGGAAAACCACCATCCGATCAGGAGAAAGGGTGGAAAGATACGGTAGCCGTCGCTCCCGATGAACGG
GTAAAAATCGAACTCACCTTCACCAAAACGGGAACGTTCATGTATCATTGCCACATCCTCGAGCATGAAGAAAATGGGAT
GATGGGACAAGTAAACGTGACCGAATGA

Upstream 100 bases:

>100_bases
TTACACAGATCACATACCCCTATATGGTATACAATAAAACGGATTTGGACTTTCATGTTTCTTTCACAATTAGGTGGTAC
AACAAAGGGAGGACTGAACA

Downstream 100 bases:

>100_bases
CCGACACCTCTCCGTTCCATCAGCGGAGAGGTGTTTTGTATCCGTCCCGATTTCGATACGTTTCTGCTAGGACTATTGCC
TGTATAGGGATTCCTTCTCG

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MKECYSMKSKGMWFLLTGILIGGIFVLLVVLFNGTWNHNNNMDQNHMMGHDSATSQMDDHMMSDNGMDDNDGPMGHGAMQ
ELQASDEPTKPLPIPTALQPDRVTGDTVYYTVEATKGTSQFFKDGKKSETFGYNGDLLGPMIELPKGKTVVIDTINRLDE
PTTFHWHGLVIPADMDGGPHQTVPPGERAQVRLDIDQEPSTLWFHPHPMGSTAEQVYKGLAGLLYVTDDAQNGLPNEYGV
DDIPLIVQDRLFTPNGELDYDAHMNVDGTTGDTILANGAINTTFDVQTETLRVRLVNGSNARDFDFTLSNEAEMTQIATD
GGPLERPIPLETLTLTPGERAEVLIDFSQVEDVAALKADGVTFTTFRIGELDKASIKIPTIETVERSTDETADRRLTLFG
MGNMVSINGKTYDPERIDIEAKRGDTEVWEIENKPDMMGGMTHPFHIHGVQFRVISRDGKPPSDQEKGWKDTVAVAPDER
VKIELTFTKTGTFMYHCHILEHEENGMMGQVNVTE

Sequences:

>Translated_515_residues
MKECYSMKSKGMWFLLTGILIGGIFVLLVVLFNGTWNHNNNMDQNHMMGHDSATSQMDDHMMSDNGMDDNDGPMGHGAMQ
ELQASDEPTKPLPIPTALQPDRVTGDTVYYTVEATKGTSQFFKDGKKSETFGYNGDLLGPMIELPKGKTVVIDTINRLDE
PTTFHWHGLVIPADMDGGPHQTVPPGERAQVRLDIDQEPSTLWFHPHPMGSTAEQVYKGLAGLLYVTDDAQNGLPNEYGV
DDIPLIVQDRLFTPNGELDYDAHMNVDGTTGDTILANGAINTTFDVQTETLRVRLVNGSNARDFDFTLSNEAEMTQIATD
GGPLERPIPLETLTLTPGERAEVLIDFSQVEDVAALKADGVTFTTFRIGELDKASIKIPTIETVERSTDETADRRLTLFG
MGNMVSINGKTYDPERIDIEAKRGDTEVWEIENKPDMMGGMTHPFHIHGVQFRVISRDGKPPSDQEKGWKDTVAVAPDER
VKIELTFTKTGTFMYHCHILEHEENGMMGQVNVTE
>Mature_515_residues
MKECYSMKSKGMWFLLTGILIGGIFVLLVVLFNGTWNHNNNMDQNHMMGHDSATSQMDDHMMSDNGMDDNDGPMGHGAMQ
ELQASDEPTKPLPIPTALQPDRVTGDTVYYTVEATKGTSQFFKDGKKSETFGYNGDLLGPMIELPKGKTVVIDTINRLDE
PTTFHWHGLVIPADMDGGPHQTVPPGERAQVRLDIDQEPSTLWFHPHPMGSTAEQVYKGLAGLLYVTDDAQNGLPNEYGV
DDIPLIVQDRLFTPNGELDYDAHMNVDGTTGDTILANGAINTTFDVQTETLRVRLVNGSNARDFDFTLSNEAEMTQIATD
GGPLERPIPLETLTLTPGERAEVLIDFSQVEDVAALKADGVTFTTFRIGELDKASIKIPTIETVERSTDETADRRLTLFG
MGNMVSINGKTYDPERIDIEAKRGDTEVWEIENKPDMMGGMTHPFHIHGVQFRVISRDGKPPSDQEKGWKDTVAVAPDER
VKIELTFTKTGTFMYHCHILEHEENGMMGQVNVTE

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=495, Percent_Identity=36.5656565656566, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1789394, Length=450, Percent_Identity=31.5555555555556, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24650186, Length=306, Percent_Identity=24.8366013071895, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859919, Length=268, Percent_Identity=28.3582089552239, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 57095; Mature: 57095

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKECYSMKSKGMWFLLTGILIGGIFVLLVVLFNGTWNHNNNMDQNHMMGHDSATSQMDDH
CCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHH
MMSDNGMDDNDGPMGHGAMQELQASDEPTKPLPIPTALQPDRVTGDTVYYTVEATKGTSQ
HHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHH
FFKDGKKSETFGYNGDLLGPMIELPKGKTVVIDTINRLDEPTTFHWHGLVIPADMDGGPH
HHHCCCCCCCCCCCCCCCCHHEECCCCCEEEEEEHHHCCCCCEEEEEEEEEEECCCCCCC
QTVPPGERAQVRLDIDQEPSTLWFHPHPMGSTAEQVYKGLAGLLYVTDDAQNGLPNEYGV
CCCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCC
DDIPLIVQDRLFTPNGELDYDAHMNVDGTTGDTILANGAINTTFDVQTETLRVRLVNGSN
CCCCEEEECEEECCCCCCCCCEEECCCCCCCCEEEECCCCCCEEEEEEEEEEEEEEECCC
ARDFDFTLSNEAEMTQIATDGGPLERPIPLETLTLTPGERAEVLIDFSQVEDVAALKADG
CCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHEECCC
VTFTTFRIGELDKASIKIPTIETVERSTDETADRRLTLFGMGNMVSINGKTYDPERIDIE
EEEEEEEECCCCCCEEECCCHHHHHCCCCCHHHCEEEEEECCCEEEECCCCCCCCEEEEE
AKRGDTEVWEIENKPDMMGGMTHPFHIHGVQFRVISRDGKPPSDQEKGWKDTVAVAPDER
ECCCCCEEEEECCCCCHHCCCCCCEEEEEEEEEEEECCCCCCCCHHCCCCCEEEECCCCE
VKIELTFTKTGTFMYHCHILEHEENGMMGQVNVTE
EEEEEEEEECCEEEEEEEEEEECCCCCEEEEEECC
>Mature Secondary Structure
MKECYSMKSKGMWFLLTGILIGGIFVLLVVLFNGTWNHNNNMDQNHMMGHDSATSQMDDH
CCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHH
MMSDNGMDDNDGPMGHGAMQELQASDEPTKPLPIPTALQPDRVTGDTVYYTVEATKGTSQ
HHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHH
FFKDGKKSETFGYNGDLLGPMIELPKGKTVVIDTINRLDEPTTFHWHGLVIPADMDGGPH
HHHCCCCCCCCCCCCCCCCHHEECCCCCEEEEEEHHHCCCCCEEEEEEEEEEECCCCCCC
QTVPPGERAQVRLDIDQEPSTLWFHPHPMGSTAEQVYKGLAGLLYVTDDAQNGLPNEYGV
CCCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCC
DDIPLIVQDRLFTPNGELDYDAHMNVDGTTGDTILANGAINTTFDVQTETLRVRLVNGSN
CCCCEEEECEEECCCCCCCCCEEECCCCCCCCEEEECCCCCCEEEEEEEEEEEEEEECCC
ARDFDFTLSNEAEMTQIATDGGPLERPIPLETLTLTPGERAEVLIDFSQVEDVAALKADG
CCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHEECCC
VTFTTFRIGELDKASIKIPTIETVERSTDETADRRLTLFGMGNMVSINGKTYDPERIDIE
EEEEEEEECCCCCCEEECCCHHHHHCCCCCHHHCEEEEEECCCEEEECCCCCCCCEEEEE
AKRGDTEVWEIENKPDMMGGMTHPFHIHGVQFRVISRDGKPPSDQEKGWKDTVAVAPDER
ECCCCCEEEEECCCCCHHCCCCCCEEEEEEEEEEEECCCCCCCCHHCCCCCEEEECCCCE
VKIELTFTKTGTFMYHCHILEHEENGMMGQVNVTE
EEEEEEEEECCEEEEEEEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA