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The map label for this gene is yvrG [H]

Identifier: 229916896

GI number: 229916896

Start: 1136837

End: 1138213

Strand: Direct

Name: yvrG [H]

Synonym: EAT1b_1169

Alternate gene names: 229916896

Gene position: 1136837-1138213 (Clockwise)

Preceding gene: 229916895

Following gene: 229916898

Centisome position: 37.9

GC content: 52.58

Gene sequence:

>1377_bases
ATGATGAAATGGAAACTGACCGGTCGCTATTTGTTGTCAATCCTCCTCATTGTGGCGCTCGTTGTCTTCTTAAACATTAC
GATTTTGTTCGGGCTCCTCGTCAATGACCGGACGGGACTTGACGATGTGGAAAGCAACTCGGGCGAGACCTTTACCCGAA
ACTTCAGTACGTATCTTTCACTCGAGGATGGCGAACCGGTCGTGTCAGAAGCGGGGCGCGAGGCCCTTCGCCAATCGGGT
GCATTCGTCCGCTTTTTAGATGAGACGGGACGAGTCGTCAGCGAGGTCGACGCTCCAAGCGGATTACCGGACGCCTATTC
TCCGATTGAGTTGATTCAAATCTATAAATACATGGATGACGACCTCCGACTCTACTTCATCGGGGAATATGAATCGTACA
GTTATCTCATCGGTGTGCCGGAGGCAAGTGAACGTCGAATACTCTTTATGTTAGACGAACAGGCGGTTCTTTCGTATATC
ACGAAGGCGTTCCTCTGGATACTTGTTGTCGATTTGCTCGTCGCCGCTTTGATCGGTGTATTGTTCAGCTCACGATTGAC
GCGCCCCGTCTACCGCTTGACCGAGCGTATTCAACAACTGAAGCAACGCGACTTCTCGACCGCTGAACCGAAGCAATCTG
GGATTTATCGCCCTGTCTTCCACGACTTGAATGCCGTCTCACAGACACTCAAAACGTATGAACGTCAGCGTGCAGAACTC
GATGACCGGCGGAAAGAGTGGATGAGCAACGTATCACACGACTTGAAGACCCCGCTCGCCTCCATCCAAGGGTACGCCGA
ACTGCTCGACGATGATTCGCTCGACGACACCGAGCGCAGACAATACGTACATGTGATCGAGCGTCAGGCTAAGTATATGA
AGGAACTGCTCGACGATTTCAATTTGACGATGCGTCTGCAGCACGACGACTTCCCGCTTACCCTCGAAGAGACAAACCTC
GAGCCGTTCGTCCGTGAGCTCGTGATTGACGTATTGAACGATTCTCGTTTCGGCGAACGCCACATCGAGTTTGAGGCCAC
TCAAGCAGCGACCGTCTCGCTCGATCGGCACTTTATGAAGCGGGCCTTGCTCAACTTCTTGTATAACGCCCTTCTCCATA
ACGACGAGTCGGTGCAGGTGACAGTCCACATCGAGGGTGACATCGTGACGATTGGAGATGATGGACATGGGATTGCTGAA
TCCGAATTGCCCTATATCTTTGAACGCTATTACCGGGGCACGAATACAGACGACGCACGCGGAAGTGGTCTCGGCATGGC
CATCTCACGGGACATCATCGAAGCCCACGGCGGGAAGGTCGAAGTCGACAGTGCACCGGGACACGGCACTTCGATTCGAA
TCACATTCATGCCATAA

Upstream 100 bases:

>100_bases
CGACGTCTCCGTGAAAAAGTCGAACCGAATCCATCCGAGCCGACTTATATCAAGACGGTCAAGGGACTTGGCTATCGGTT
GACGGTATAAAGGAGCGATC

Downstream 100 bases:

>100_bases
CAAAAGGGACGCTCAGGCGTCCCTTGTCTGTGTCGTATAGTCAGCAATCCATGTTTCTAGTTCTTCAAGCGGTAACGGTC
TAGAGAAATAATACCCCTGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MMKWKLTGRYLLSILLIVALVVFLNITILFGLLVNDRTGLDDVESNSGETFTRNFSTYLSLEDGEPVVSEAGREALRQSG
AFVRFLDETGRVVSEVDAPSGLPDAYSPIELIQIYKYMDDDLRLYFIGEYESYSYLIGVPEASERRILFMLDEQAVLSYI
TKAFLWILVVDLLVAALIGVLFSSRLTRPVYRLTERIQQLKQRDFSTAEPKQSGIYRPVFHDLNAVSQTLKTYERQRAEL
DDRRKEWMSNVSHDLKTPLASIQGYAELLDDDSLDDTERRQYVHVIERQAKYMKELLDDFNLTMRLQHDDFPLTLEETNL
EPFVRELVIDVLNDSRFGERHIEFEATQAATVSLDRHFMKRALLNFLYNALLHNDESVQVTVHIEGDIVTIGDDGHGIAE
SELPYIFERYYRGTNTDDARGSGLGMAISRDIIEAHGGKVEVDSAPGHGTSIRITFMP

Sequences:

>Translated_458_residues
MMKWKLTGRYLLSILLIVALVVFLNITILFGLLVNDRTGLDDVESNSGETFTRNFSTYLSLEDGEPVVSEAGREALRQSG
AFVRFLDETGRVVSEVDAPSGLPDAYSPIELIQIYKYMDDDLRLYFIGEYESYSYLIGVPEASERRILFMLDEQAVLSYI
TKAFLWILVVDLLVAALIGVLFSSRLTRPVYRLTERIQQLKQRDFSTAEPKQSGIYRPVFHDLNAVSQTLKTYERQRAEL
DDRRKEWMSNVSHDLKTPLASIQGYAELLDDDSLDDTERRQYVHVIERQAKYMKELLDDFNLTMRLQHDDFPLTLEETNL
EPFVRELVIDVLNDSRFGERHIEFEATQAATVSLDRHFMKRALLNFLYNALLHNDESVQVTVHIEGDIVTIGDDGHGIAE
SELPYIFERYYRGTNTDDARGSGLGMAISRDIIEAHGGKVEVDSAPGHGTSIRITFMP
>Mature_458_residues
MMKWKLTGRYLLSILLIVALVVFLNITILFGLLVNDRTGLDDVESNSGETFTRNFSTYLSLEDGEPVVSEAGREALRQSG
AFVRFLDETGRVVSEVDAPSGLPDAYSPIELIQIYKYMDDDLRLYFIGEYESYSYLIGVPEASERRILFMLDEQAVLSYI
TKAFLWILVVDLLVAALIGVLFSSRLTRPVYRLTERIQQLKQRDFSTAEPKQSGIYRPVFHDLNAVSQTLKTYERQRAEL
DDRRKEWMSNVSHDLKTPLASIQGYAELLDDDSLDDTERRQYVHVIERQAKYMKELLDDFNLTMRLQHDDFPLTLEETNL
EPFVRELVIDVLNDSRFGERHIEFEATQAATVSLDRHFMKRALLNFLYNALLHNDESVQVTVHIEGDIVTIGDDGHGIAE
SELPYIFERYYRGTNTDDARGSGLGMAISRDIIEAHGGKVEVDSAPGHGTSIRITFMP

Specific function: Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon. Probably activates yv

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=27.9569892473118, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=26.8595041322314, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=26.1410788381743, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=27.0742358078603, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=300, Percent_Identity=25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=26.7241379310345, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=27.7056277056277, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=218, Percent_Identity=25.6880733944954, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=24.113475177305, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=26.431718061674, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=219, Percent_Identity=26.027397260274, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789403, Length=306, Percent_Identity=24.1830065359477, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=320, Percent_Identity=24.0625, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52320; Mature: 52320

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKWKLTGRYLLSILLIVALVVFLNITILFGLLVNDRTGLDDVESNSGETFTRNFSTYLS
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCEEEEE
LEDGEPVVSEAGREALRQSGAFVRFLDETGRVVSEVDAPSGLPDAYSPIELIQIYKYMDD
ECCCCHHHHHHHHHHHHHCCCEEEEHHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
DLRLYFIGEYESYSYLIGVPEASERRILFMLDEQAVLSYITKAFLWILVVDLLVAALIGV
CEEEEEEECCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFSSRLTRPVYRLTERIQQLKQRDFSTAEPKQSGIYRPVFHDLNAVSQTLKTYERQRAEL
HHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DDRRKEWMSNVSHDLKTPLASIQGYAELLDDDSLDDTERRQYVHVIERQAKYMKELLDDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NLTMRLQHDDFPLTLEETNLEPFVRELVIDVLNDSRFGERHIEFEATQAATVSLDRHFMK
CEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHH
RALLNFLYNALLHNDESVQVTVHIEGDIVTIGDDGHGIAESELPYIFERYYRGTNTDDAR
HHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCC
GSGLGMAISRDIIEAHGGKVEVDSAPGHGTSIRITFMP
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECC
>Mature Secondary Structure
MMKWKLTGRYLLSILLIVALVVFLNITILFGLLVNDRTGLDDVESNSGETFTRNFSTYLS
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCEEEEE
LEDGEPVVSEAGREALRQSGAFVRFLDETGRVVSEVDAPSGLPDAYSPIELIQIYKYMDD
ECCCCHHHHHHHHHHHHHCCCEEEEHHHHCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
DLRLYFIGEYESYSYLIGVPEASERRILFMLDEQAVLSYITKAFLWILVVDLLVAALIGV
CEEEEEEECCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFSSRLTRPVYRLTERIQQLKQRDFSTAEPKQSGIYRPVFHDLNAVSQTLKTYERQRAEL
HHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DDRRKEWMSNVSHDLKTPLASIQGYAELLDDDSLDDTERRQYVHVIERQAKYMKELLDDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NLTMRLQHDDFPLTLEETNLEPFVRELVIDVLNDSRFGERHIEFEATQAATVSLDRHFMK
CEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHH
RALLNFLYNALLHNDESVQVTVHIEGDIVTIGDDGHGIAESELPYIFERYYRGTNTDDAR
HHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCC
GSGLGMAISRDIIEAHGGKVEVDSAPGHGTSIRITFMP
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]