Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 229587248

GI number: 229587248

Start: 1263620

End: 1264444

Strand: Direct

Name: nhaA [H]

Synonym: RAF_ORF1241

Alternate gene names: 229587248

Gene position: 1263620-1264444 (Clockwise)

Preceding gene: 229587242

Following gene: 229587256

Centisome position: 98.83

GC content: 28.85

Gene sequence:

>825_bases
GTGAACATAAAAATAAAAAAACTAATATTACCTGCAGCGGCAGCCCTTGGAGGTGTGGTAATTCTAATATACATGTTTTT
TAATTACGATAAACCGGGATTAATAAAAGGATGGGCTATTCCTATCGCAACTTATACTGCTTTTGTCCTTGGTATTTTAT
CTTTTTTCAGCCGACATATATCTTTAGAATTACGAGCTTTTATTATAGGTTTTTCATTAATTGACGATGCTTTTGCGTTA
ATTATGCTAGTTTATACTAAAACAATCAATACTCCGGCATTATTAATTTCCTCTATAATTATATTCATCTTGTTTATATT
GAATTATCGACAAGTTAAACAATTATTTTATTATATAATTGTAGGTTTATTATTATGGATTAGTATGGTGGAGTCAGGTA
TTCACGATACCTTATGCAGAGCCATTATAGCACTTTTTATACCTGTTAATATAAAAGGAGAATTTAACACTTCTTTTAAA
AAACTTGAAAACTTAACTCGTCCTTTTGTAAATTACTTTATTTTACCGCTTTTTGTATTTATGAATTCCGGTATCTTTTT
AGAATATTTTGCATTTAAAGGCATTTGTTCCAACTCAATACTTGCTTTAATTTATGGGATAATATTTGGTTTATTTGTAG
GTAAGCAATTAGGTATTATGCTATTTTCATATCCATTTGTAAAATTTAAACTCTGTAACTTACCAAGTGATACTTCATGG
TTAAAATTTTATTCTATAGCTATACTTGGAGGGATTGGATTTACCCTAAGTTTATTTATAGGTAGTATTTTACGTTTGAG
AGCAGCTGCCCTTCAAACTCTATGA

Upstream 100 bases:

>100_bases
AAAGTACAAAAAACAACTTTTATAGAGTTAGTTAATGACGGTCTCATGACTTTCTTCTTTTTATTAATAGGTTTAGAGAT
GAAATTTCACCTAGTAGAAG

Downstream 100 bases:

>100_bases
GAGCTGCAGTAATAATAGACTCTTTAATTTCTGCATTATTTGGCGTAGCCGTTCTGAAATATTGTACTGGAAAAGAGTAA
AGAAGAAATTAAACGAGTAT

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNIKIKKLILPAAAALGGVVILIYMFFNYDKPGLIKGWAIPIATYTAFVLGILSFFSRHISLELRAFIIGFSLIDDAFAL
IMLVYTKTINTPALLISSIIIFILFILNYRQVKQLFYYIIVGLLLWISMVESGIHDTLCRAIIALFIPVNIKGEFNTSFK
KLENLTRPFVNYFILPLFVFMNSGIFLEYFAFKGICSNSILALIYGIIFGLFVGKQLGIMLFSYPFVKFKLCNLPSDTSW
LKFYSIAILGGIGFTLSLFIGSILRLRAAALQTL

Sequences:

>Translated_274_residues
MNIKIKKLILPAAAALGGVVILIYMFFNYDKPGLIKGWAIPIATYTAFVLGILSFFSRHISLELRAFIIGFSLIDDAFAL
IMLVYTKTINTPALLISSIIIFILFILNYRQVKQLFYYIIVGLLLWISMVESGIHDTLCRAIIALFIPVNIKGEFNTSFK
KLENLTRPFVNYFILPLFVFMNSGIFLEYFAFKGICSNSILALIYGIIFGLFVGKQLGIMLFSYPFVKFKLCNLPSDTSW
LKFYSIAILGGIGFTLSLFIGSILRLRAAALQTL
>Mature_274_residues
MNIKIKKLILPAAAALGGVVILIYMFFNYDKPGLIKGWAIPIATYTAFVLGILSFFSRHISLELRAFIIGFSLIDDAFAL
IMLVYTKTINTPALLISSIIIFILFILNYRQVKQLFYYIIVGLLLWISMVESGIHDTLCRAIIALFIPVNIKGEFNTSFK
KLENLTRPFVNYFILPLFVFMNSGIFLEYFAFKGICSNSILALIYGIIFGLFVGKQLGIMLFSYPFVKFKLCNLPSDTSW
LKFYSIAILGGIGFTLSLFIGSILRLRAAALQTL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=264, Percent_Identity=39.0151515151515, Blast_Score=172, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 30862; Mature: 30862

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKIKKLILPAAAALGGVVILIYMFFNYDKPGLIKGWAIPIATYTAFVLGILSFFSRHI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLELRAFIIGFSLIDDAFALIMLVYTKTINTPALLISSIIIFILFILNYRQVKQLFYYII
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLLLWISMVESGIHDTLCRAIIALFIPVNIKGEFNTSFKKLENLTRPFVNYFILPLFVF
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MNSGIFLEYFAFKGICSNSILALIYGIIFGLFVGKQLGIMLFSYPFVKFKLCNLPSDTSW
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHH
LKFYSIAILGGIGFTLSLFIGSILRLRAAALQTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIKIKKLILPAAAALGGVVILIYMFFNYDKPGLIKGWAIPIATYTAFVLGILSFFSRHI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLELRAFIIGFSLIDDAFALIMLVYTKTINTPALLISSIIIFILFILNYRQVKQLFYYII
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLLLWISMVESGIHDTLCRAIIALFIPVNIKGEFNTSFKKLENLTRPFVNYFILPLFVF
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MNSGIFLEYFAFKGICSNSILALIYGIIFGLFVGKQLGIMLFSYPFVKFKLCNLPSDTSW
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHH
LKFYSIAILGGIGFTLSLFIGSILRLRAAALQTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA