Click here to switch to the map view.

The map label for this gene is dapA [H]

Identifier: 229586707

GI number: 229586707

Start: 583772

End: 584656

Strand: Direct

Name: dapA [H]

Synonym: RAF_ORF0554

Alternate gene names: 229586707

Gene position: 583772-584656 (Clockwise)

Preceding gene: 229586706

Following gene: 229586708

Centisome position: 45.66

GC content: 33.56

Gene sequence:

>885_bases
ATGCATAACATATTTAAAGGTTTAATTACCGCACTTATAACACCTTTTAAAGATAATAAGTTAGACTTATATGCTTTAGA
GAGAATTGTAAAACATCAAATAAAGCATGAAGTCGATGCAGTATTAATTGCAGGCTCAACGGGAGAAAGTAGTAGTTTAA
GCTTTGAAGAATATAAATTATTACTGCAAACTAGCGTAGAAATCGTTAATAAGTGTATTCCTATAATAAGCGGGTGTTCA
TCAAATAATACTACTTATGCAAGAGCACTTGCAGCGGAATCTACAAAAATCGGCGTAGATGGTTTTATGGCTAGTCCACC
ATCTTATGTCAAACCTACCCAACACGGGATTTATAAGCATTTTGAAGCATTGCATGAAGTGTGTAATCTACCTATTATGT
TATATTCAGCTCCAACTAGAAGCGGAGTAGATTTTTCTGATGAGACAATATTGAGACTTAGCAAGCTACCGCGTATTTTA
GCATTAAAAGATTGTGGTGTAGATTTAGAACGTCCATTGCGGATCAGAGCAACAGTTAAAAAGGATTTCAATATTTTAAC
CGGTAATGATGAAGTAGTCTTAGCTTTTAACGCTCAAGGTGGGGTGGGGTGGACTTCTGTAGCCTCTAATATTGTTCCTA
ATATATGTAAAGAGCTATTAGAAAAATGGAATAAGAATGATACTAAAGGAGCATTAGAAATCCATCAGAAATTACTACCT
TTATATACAGCATTATTTGTAGAATCTAATCCGATTCCGATAAAATATGCTGCACATTATTTAGGTTTATGTGAAAATGA
AATTAGACCCCCATTAACTGAAGCAAGCGATAGTGCCAAAAAACAAATTGAAAACATCATAACATCACTATCTATAAAAA
TATGA

Upstream 100 bases:

>100_bases
TGAAATAATAACAAACTCCTGAGATTGCTTCGTCGAATTACTACGTAATTCTTCTCGCAATGACGATTTAATAAGCTAAA
CAATTAAAATCAAAAAAATC

Downstream 100 bases:

>100_bases
CTGAATATAAGAAAGTTATTGCACAAAATAAGAAAGCCCTTTTTAATTATTTTATTGCAGAAAGATTAGAAGCGGGTATT
GTATTAAAGGGTAGTGAAGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MHNIFKGLITALITPFKDNKLDLYALERIVKHQIKHEVDAVLIAGSTGESSSLSFEEYKLLLQTSVEIVNKCIPIISGCS
SNNTTYARALAAESTKIGVDGFMASPPSYVKPTQHGIYKHFEALHEVCNLPIMLYSAPTRSGVDFSDETILRLSKLPRIL
ALKDCGVDLERPLRIRATVKKDFNILTGNDEVVLAFNAQGGVGWTSVASNIVPNICKELLEKWNKNDTKGALEIHQKLLP
LYTALFVESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITSLSIKI

Sequences:

>Translated_294_residues
MHNIFKGLITALITPFKDNKLDLYALERIVKHQIKHEVDAVLIAGSTGESSSLSFEEYKLLLQTSVEIVNKCIPIISGCS
SNNTTYARALAAESTKIGVDGFMASPPSYVKPTQHGIYKHFEALHEVCNLPIMLYSAPTRSGVDFSDETILRLSKLPRIL
ALKDCGVDLERPLRIRATVKKDFNILTGNDEVVLAFNAQGGVGWTSVASNIVPNICKELLEKWNKNDTKGALEIHQKLLP
LYTALFVESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITSLSIKI
>Mature_294_residues
MHNIFKGLITALITPFKDNKLDLYALERIVKHQIKHEVDAVLIAGSTGESSSLSFEEYKLLLQTSVEIVNKCIPIISGCS
SNNTTYARALAAESTKIGVDGFMASPPSYVKPTQHGIYKHFEALHEVCNLPIMLYSAPTRSGVDFSDETILRLSKLPRIL
ALKDCGVDLERPLRIRATVKKDFNILTGNDEVVLAFNAQGGVGWTSVASNIVPNICKELLEKWNKNDTKGALEIHQKLLP
LYTALFVESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITSLSIKI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=23.7931034482759, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI13540533, Length=240, Percent_Identity=27.5, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788823, Length=284, Percent_Identity=32.7464788732394, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=28.2828282828283, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786463, Length=242, Percent_Identity=29.3388429752066, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789620, Length=210, Percent_Identity=30.4761904761905, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32504; Mature: 32504

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNIFKGLITALITPFKDNKLDLYALERIVKHQIKHEVDAVLIAGSTGESSSLSFEEYKL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHH
LLQTSVEIVNKCIPIISGCSSNNTTYARALAAESTKIGVDGFMASPPSYVKPTQHGIYKH
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHH
FEALHEVCNLPIMLYSAPTRSGVDFSDETILRLSKLPRILALKDCGVDLERPLRIRATVK
HHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEEHHHCCCCCCCCEEEEEEEC
KDFNILTGNDEVVLAFNAQGGVGWTSVASNIVPNICKELLEKWNKNDTKGALEIHQKLLP
CCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LYTALFVESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITSLSIKI
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHNIFKGLITALITPFKDNKLDLYALERIVKHQIKHEVDAVLIAGSTGESSSLSFEEYKL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHH
LLQTSVEIVNKCIPIISGCSSNNTTYARALAAESTKIGVDGFMASPPSYVKPTQHGIYKH
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHH
FEALHEVCNLPIMLYSAPTRSGVDFSDETILRLSKLPRILALKDCGVDLERPLRIRATVK
HHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEEHHHCCCCCCCCEEEEEEEC
KDFNILTGNDEVVLAFNAQGGVGWTSVASNIVPNICKELLEKWNKNDTKGALEIHQKLLP
CCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LYTALFVESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITSLSIKI
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA