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The map label for this gene is hflK [H]

Identifier: 229586362

GI number: 229586362

Start: 163815

End: 164855

Strand: Direct

Name: hflK [H]

Synonym: RAF_ORF0153

Alternate gene names: 229586362

Gene position: 163815-164855 (Clockwise)

Preceding gene: 229586358

Following gene: 229586363

Centisome position: 12.81

GC content: 35.16

Gene sequence:

>1041_bases
ATGCTGAATAAAAAACATACCTCAATTTTAAAAAAATCCCCATGGAAAGATTTTGATTCTGATAAAGAAGATAACATATT
CACAAGACCGCGTAAAAATCAATTTAATTTTGATCAATTTCAATTCCCGTTTAATTTCAATGCTAAAACAATAATTTTAG
CTGTTGTTGCAGTGGTTGCTTTATGGCTCGCTTCGGGTATTTATGAAATAAAAGAAGGCGAAGAAGCAGCGGTAATAAGA
TTTGGGCGTTTTGTGCGTAAGGGCTACCCCGGGCTTAATTATCATTTACCGGCACCTTTTGAAAAGATAATAGTTGAAAA
AGTTAAACAATCACGTCGGATTGAGATTGGTTATCGTACAAATAGCTCTCTGCGTAGCGGTGGTGATAATACTAAAAATA
TTGCCGGTGAAAGTATAATGCTCACCGGTGATGAAAATATCATTGCTTTAAATTGTGACGTAATGTGGCATATTAATAAT
CTTGAAGATTTTATTTTTAACGTACAAAGACCTGCAGAAACAGTAAAAGCAACAGTCGAGAGTGCCGTTAGGGAAGTCAT
AGGCAATACTCCTATTTCTTGGGTATTATCCGATCAAAAGCAGGAGATTACTTATAAAATAGAGAAATTAGCACAGAAGA
TATTGGATAGTTATAATGCCGGCGTTATGATTGAGAAAGTACAATTATTAAAAGCCGAGCCGCCTGCCGAAGTAATAGAC
GCTTATAGAGACGTGCAAACTTCAAAAGCAGATAAAGAAAAAGAAATAAATCAAGCTCAAGCCTATAATAATAAGATTTT
GCCGGAAGCTAGAGGAGCGGCTGCAAAGATTATACAAGAAGCAGAAGGTTATAGAGCAGAAGTTATATCGAAAGCAGAAG
GTGATAGCCAAAGATTTAATGCTATTTATAAACAATATGCTACAGGTAGGCAAATAACTAGAGATAGATTATATTTAGAA
GTAGTCGAAGAGATATTAGGCGGTTCAAATAAAACGATTATTAATAATGCACTACTGCCGCACATGGCTATTAAACCATA
G

Upstream 100 bases:

>100_bases
AATTTCCTTTTTAAAGCTGTTTAAGCTCGTAACTTGACGTTATATACTATAATATATATAATTATCTCATCTTTAAAAGT
AATATAAAACAATAAAGCAA

Downstream 100 bases:

>100_bases
GGGTGCTATGTCATTCCCGCTTTTGCGGGCATGACATCAAGCGTGTTTTTCACGCTATACACAAATGACATCTAAACAAC
AAGGAATATTAAATGCAACA

Product: Protease activity modulator HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLNKKHTSILKKSPWKDFDSDKEDNIFTRPRKNQFNFDQFQFPFNFNAKTIILAVVAVVALWLASGIYEIKEGEEAAVIR
FGRFVRKGYPGLNYHLPAPFEKIIVEKVKQSRRIEIGYRTNSSLRSGGDNTKNIAGESIMLTGDENIIALNCDVMWHINN
LEDFIFNVQRPAETVKATVESAVREVIGNTPISWVLSDQKQEITYKIEKLAQKILDSYNAGVMIEKVQLLKAEPPAEVID
AYRDVQTSKADKEKEINQAQAYNNKILPEARGAAAKIIQEAEGYRAEVISKAEGDSQRFNAIYKQYATGRQITRDRLYLE
VVEEILGGSNKTIINNALLPHMAIKP

Sequences:

>Translated_346_residues
MLNKKHTSILKKSPWKDFDSDKEDNIFTRPRKNQFNFDQFQFPFNFNAKTIILAVVAVVALWLASGIYEIKEGEEAAVIR
FGRFVRKGYPGLNYHLPAPFEKIIVEKVKQSRRIEIGYRTNSSLRSGGDNTKNIAGESIMLTGDENIIALNCDVMWHINN
LEDFIFNVQRPAETVKATVESAVREVIGNTPISWVLSDQKQEITYKIEKLAQKILDSYNAGVMIEKVQLLKAEPPAEVID
AYRDVQTSKADKEKEINQAQAYNNKILPEARGAAAKIIQEAEGYRAEVISKAEGDSQRFNAIYKQYATGRQITRDRLYLE
VVEEILGGSNKTIINNALLPHMAIKP
>Mature_346_residues
MLNKKHTSILKKSPWKDFDSDKEDNIFTRPRKNQFNFDQFQFPFNFNAKTIILAVVAVVALWLASGIYEIKEGEEAAVIR
FGRFVRKGYPGLNYHLPAPFEKIIVEKVKQSRRIEIGYRTNSSLRSGGDNTKNIAGESIMLTGDENIIALNCDVMWHINN
LEDFIFNVQRPAETVKATVESAVREVIGNTPISWVLSDQKQEITYKIEKLAQKILDSYNAGVMIEKVQLLKAEPPAEVID
AYRDVQTSKADKEKEINQAQAYNNKILPEARGAAAKIIQEAEGYRAEVISKAEGDSQRFNAIYKQYATGRQITRDRLYLE
VVEEILGGSNKTIINNALLPHMAIKP

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=272, Percent_Identity=29.4117647058824, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 39211; Mature: 39211

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKKHTSILKKSPWKDFDSDKEDNIFTRPRKNQFNFDQFQFPFNFNAKTIILAVVAVVA
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
LWLASGIYEIKEGEEAAVIRFGRFVRKGYPGLNYHLPAPFEKIIVEKVKQSRRIEIGYRT
HHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECC
NSSLRSGGDNTKNIAGESIMLTGDENIIALNCDVMWHINNLEDFIFNVQRPAETVKATVE
CCHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEECCHHHHHHHCCCHHHHHHHHHH
SAVREVIGNTPISWVLSDQKQEITYKIEKLAQKILDSYNAGVMIEKVQLLKAEPPAEVID
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCHHHHH
AYRDVQTSKADKEKEINQAQAYNNKILPEARGAAAKIIQEAEGYRAEVISKAEGDSQRFN
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHH
AIYKQYATGRQITRDRLYLEVVEEILGGSNKTIINNALLPHMAIKP
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MLNKKHTSILKKSPWKDFDSDKEDNIFTRPRKNQFNFDQFQFPFNFNAKTIILAVVAVVA
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
LWLASGIYEIKEGEEAAVIRFGRFVRKGYPGLNYHLPAPFEKIIVEKVKQSRRIEIGYRT
HHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECC
NSSLRSGGDNTKNIAGESIMLTGDENIIALNCDVMWHINNLEDFIFNVQRPAETVKATVE
CCHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEECCHHHHHHHCCCHHHHHHHHHH
SAVREVIGNTPISWVLSDQKQEITYKIEKLAQKILDSYNAGVMIEKVQLLKAEPPAEVID
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCHHHHH
AYRDVQTSKADKEKEINQAQAYNNKILPEARGAAAKIIQEAEGYRAEVISKAEGDSQRFN
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHH
AIYKQYATGRQITRDRLYLEVVEEILGGSNKTIINNALLPHMAIKP
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]