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The map label for this gene is hflC2 [H]

Identifier: 229586363

GI number: 229586363

Start: 164948

End: 165808

Strand: Direct

Name: hflC2 [H]

Synonym: RAF_ORF0154

Alternate gene names: 229586363

Gene position: 164948-165808 (Clockwise)

Preceding gene: 229586362

Following gene: 229586364

Centisome position: 12.9

GC content: 33.68

Gene sequence:

>861_bases
ATGCAACAAAAGATTTATTCTATAATTTTTACAATTGTTTTTGGGCTGATACTGATTTCTAGCTCCTTATTTTCAGTTGA
CCAACGCCAATCTGCAGTAGTATTCCAGTTTGGTGAGGCAGTTAGAACTATAGAAAATCCAGGACTGAATATTAAAATCC
CGTTTATTCAAAATGTTGAATTTTTTGATAAGCGTCTTTTAGATGTTGAGGTTGAGGCAAAAGAATTAACGGCTGCTGAC
GGTAAACGAGTTATTGTTGATGCCTACGCCAAATTCCAAATTAATAATCCCGTAATGTTTTATAAAACGGTACATGATTA
TCAAGGTGTGAAAATTAGGCTGACTCGTAATCTTGAATCGTCAATGCGTAAGGTGATAGGTAAAATCTCGCTAAGTAGCC
TTTTAAGTCAGGAACGTAGTAATGTAATGTTAAATATCTTAAATCAAGTGGACGGTGAAGCTAAAAGCTTCGGTATTGAT
GTTGTAGATGTTAGAATTTTAAGAGCAGACTTACCAAAAGAAAATAGTGCGGCTATTTATCGTCGTATGCAAACGGCACG
TGAAAAAGAAGCAACCCAAATTAGAGCGGAAGGACAAGAAGAAAGCGTGCGTATTCGTTCAAAAGCAGATAAAGAAAGTA
AAATAATACTTGCTAAAGCTTATCGAGATGCACAAATTATTAAAGGTGACGGTGATGAGAAGGCGGCAAAAATATATAAT
GCTGCTTATTCAGTTGATCCGGAATTTTATAAATTTTATAGATCACTTTTAGTATATAAAAATTCTTTAAAGAAAGAGAA
TACTAATTTTGTAATTTCACCGGATGCTGAAGTTTTAAAATATCTAAATCTCACTAAATAG

Upstream 100 bases:

>100_bases
AACCATAGGGGTGCTATGTCATTCCCGCTTTTGCGGGCATGACATCAAGCGTGTTTTTCACGCTATACACAAATGACATC
TAAACAACAAGGAATATTAA

Downstream 100 bases:

>100_bases
TATACTAGTTTATCTACTTTTTATTTACTTGGAGTATATGGTTAATCTGAAAATAGTTATTGTTATAATAGTTTTAATAT
CAAGTAACGTTGTTCTAGCA

Product: Membrane protease subunit, stomatin/prohibitin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQQKIYSIIFTIVFGLILISSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVEFFDKRLLDVEVEAKELTAAD
GKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGKISLSSLLSQERSNVMLNILNQVDGEAKSFGID
VVDVRILRADLPKENSAAIYRRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
AAYSVDPEFYKFYRSLLVYKNSLKKENTNFVISPDAEVLKYLNLTK

Sequences:

>Translated_286_residues
MQQKIYSIIFTIVFGLILISSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVEFFDKRLLDVEVEAKELTAAD
GKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGKISLSSLLSQERSNVMLNILNQVDGEAKSFGID
VVDVRILRADLPKENSAAIYRRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
AAYSVDPEFYKFYRSLLVYKNSLKKENTNFVISPDAEVLKYLNLTK
>Mature_286_residues
MQQKIYSIIFTIVFGLILISSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVEFFDKRLLDVEVEAKELTAAD
GKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGKISLSSLLSQERSNVMLNILNQVDGEAKSFGID
VVDVRILRADLPKENSAAIYRRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
AAYSVDPEFYKFYRSLLVYKNSLKKENTNFVISPDAEVLKYLNLTK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=308, Percent_Identity=31.8181818181818, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786697, Length=234, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17569497, Length=212, Percent_Identity=25.9433962264151, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=214, Percent_Identity=24.7663551401869, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32611; Mature: 32611

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKIYSIIFTIVFGLILISSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHCCCCCEEEECCCCCHH
FFDKRLLDVEVEAKELTAADGKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLES
HHHHHHHCEEECHHHHHCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCHHH
SMRKVIGKISLSSLLSQERSNVMLNILNQVDGEAKSFGIDVVDVRILRADLPKENSAAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCCHHHHH
RRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
HHHHHHHHHHHHHHHCCCCCHHEEEHHCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHH
AAYSVDPEFYKFYRSLLVYKNSLKKENTNFVISPDAEVLKYLNLTK
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MQQKIYSIIFTIVFGLILISSSLFSVDQRQSAVVFQFGEAVRTIENPGLNIKIPFIQNVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHCCCCCEEEECCCCCHH
FFDKRLLDVEVEAKELTAADGKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLES
HHHHHHHCEEECHHHHHCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCHHH
SMRKVIGKISLSSLLSQERSNVMLNILNQVDGEAKSFGIDVVDVRILRADLPKENSAAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCCHHHHH
RRMQTAREKEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKAAKIYN
HHHHHHHHHHHHHHHCCCCCHHEEEHHCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHH
AAYSVDPEFYKFYRSLLVYKNSLKKENTNFVISPDAEVLKYLNLTK
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]