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The map label for this gene is ndk

Identifier: 229586295

GI number: 229586295

Start: 76636

End: 77058

Strand: Direct

Name: ndk

Synonym: RAF_ORF0078

Alternate gene names: 229586295

Gene position: 76636-77058 (Clockwise)

Preceding gene: 229586294

Following gene: 229586296

Centisome position: 5.99

GC content: 32.15

Gene sequence:

>423_bases
ATGACAATACAATATACTTTTTCAATGATTAAGCCTGATGCTATCAAAAGGAATAAAATAGGGCAAGTTAATACTTACTT
AGAAAATGCCGGTTTAAAAATAGTGGCTCAGAAAATGAAATTTTTAACTAAATATGAAGCTGCATGTTTTTATGATGAGC
ATAGAGCAAGACCATTTTTTAATAGCTTAGTTGAATATATTACTTCAGGAGCGGTAGTACTTCAAGTGCTTAAGGGGGAG
GATGCTATAACTTTAAACCGTACCGTTATGGGTGCAACTAATCCTGCTGAAGCTGAAGCAGGTACTATTAGAAAAGATTT
AGGCGAATCAATTGAGGCTAATAGTATTCATGGTTCAGATAGTGAAAATAGTGCGAAAAGAGAAATCGAATTTTTCTTTA
ATAAATCTGAAATTATAGAATAA

Upstream 100 bases:

>100_bases
TTTCAGTATTTCTGCTCTTTTAGGAGGAGGATTATTTGCTTTAATATGGAATCGTTCAGCTAAAAAATATATTTAATAAT
TATAATAAATAGGTTACAAA

Downstream 100 bases:

>100_bases
TTAATGCTAAAATATGACGTAATAGTTATAGGCGGTGGACATGCAGGCGTAGAAGCAGCCGCTGCTTCTGCGCGTCTTGG
AGTTCCTACTCTCTTAATTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFFNSLVEYITSGAVVLQVLKGE
DAITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIEFFFNKSEIIE

Sequences:

>Translated_140_residues
MTIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFFNSLVEYITSGAVVLQVLKGE
DAITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIEFFFNKSEIIE
>Mature_139_residues
TIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFFNSLVEYITSGAVVLQVLKGED
AITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIEFFFNKSEIIE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=134, Percent_Identity=41.7910447761194, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392203, Length=140, Percent_Identity=39.2857142857143, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI66392227, Length=140, Percent_Identity=39.2857142857143, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI66392205, Length=140, Percent_Identity=39.2857142857143, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4505409, Length=140, Percent_Identity=39.2857142857143, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI66392192, Length=140, Percent_Identity=39.2857142857143, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=36.6906474820144, Blast_Score=103, Evalue=5e-23,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=37.956204379562, Blast_Score=103, Evalue=5e-23,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=37.956204379562, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=38.1294964028777, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=38.1294964028777, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.037037037037, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=30.3703703703704, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=50.7246376811594, Blast_Score=147, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17506807, Length=133, Percent_Identity=40.6015037593985, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=140, Percent_Identity=38.5714285714286, Blast_Score=111, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45549037, Length=134, Percent_Identity=41.044776119403, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.089552238806, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_RICAE (C3PM93)

Other databases:

- EMBL:   CP001612
- RefSeq:   YP_002844796.1
- ProteinModelPortal:   C3PM93
- SMR:   C3PM93
- GeneID:   7815921
- GenomeReviews:   CP001612_GR
- KEGG:   raf:RAF_ORF0078
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15690; Mature: 15559

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFF
CEEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
NSLVEYITSGAVVLQVLKGEDAITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSD
HHHHHHHHCCHHHHHHHCCCCEEEECCEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
SENSAKREIEFFFNKSEIIE
CCCHHHHHHHHEECHHHHCC
>Mature Secondary Structure 
TIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFF
EEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
NSLVEYITSGAVVLQVLKGEDAITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSD
HHHHHHHHCCHHHHHHHCCCCEEEECCEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
SENSAKREIEFFFNKSEIIE
CCCHHHHHHHHEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA