BacMap

Definition	Sulfolobus islandicus M.14.25 chromosome, complete genome.
Accession	NC_012588
Length	2,608,832

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The map label for this gene is yeaE [H]

Identifier: 227828408

GI number: 227828408

Start: 1970584

End: 1971381

Strand: Direct

Name: yeaE [H]

Synonym: M1425_2151

Alternate gene names: 227828408

Gene position: 1970584-1971381 (Clockwise)

Preceding gene: 227828407

Following gene: 227828409

Centisome position: 75.54

GC content: 34.09

Gene sequence:

>798_bases
ATGAAGTTATGTAACAAAGAGATATCGCAAATTGGGTTTGGGACCTGGAAAATTGGCGGAGGTTACTGGAATCCAGATTA
TTCTATGGATTCCTATTATATCGAGATATTAAAGTATGTAATAAGTAAGGGAATAAACGTTATCGATACTGCGGAAATGT
ACGGTGGAGGGCATTCTGAAGAACTAGTTGGAAAATCTATACAAGATTTAGATAGAGATGGAATTTTCATTATAACCAAG
GTATGGTCTAATCACTTGAGATATGATGATTTAATAAGATCTGCTAAAAATAGTCTAAGAAGGCTCAACTCAAAGTATAT
TGATCTATATTTAATCCATTGGCCAAATTCTTCAGTACCTTTAGAGGAAAGTATAAGGGCAATGGAGGAATTGGTAGATC
AAGGCATTGTAAATTGTATTGGAGTGAGCAATTTTGATGTCAAACTTTTAGAAGAGGCCATGTCGTTAACTAAAAAATAT
GAAATAGTTGCAAATGAAATAGAGTACAATGTTGAGAATAAAAGCGCAGAAAAGGATGTTATACCGTTCTGTGAAAGGAA
TAATATAAAAGTAATAGCCTATTCTCCTCTCGCTAGAGGAAATATCAAGAACAACAAGATATTAGATGAGATCGGACGAA
AATATAACAGAACTTCTGTTCAAGTGGCATTAAACTACCTTATGAGGAGATCGATACCAATACCTAAGGCATCGAGTAAA
GATCATATTGATGAGATCTTGGGAGCTTTAGGATGGAATTTAAGTGACGAGGATTATGAGAGAATTTCCAAAATCTAA

Upstream 100 bases:

>100_bases
CTTGGGAGATTAAGTCTGCCTTAATAAGGGGTTTAGAGAAAGTGAGAAAAGAGAATAAAATAGCTGTGATTCAAGTTATA
GTGGATAAGGTGAGGTAATT

Downstream 100 bases:

>100_bases
ATAACTTGGAAACTTTGAAATGAATAGAAACCGTTTTAAAAGATATAAAAAGTGTGGTGTCCATAATCTTGCTATAACAT
GAACTCGTTTTGAACAGGAG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKLCNKEISQIGFGTWKIGGGYWNPDYSMDSYYIEILKYVISKGINVIDTAEMYGGGHSEELVGKSIQDLDRDGIFIITK
VWSNHLRYDDLIRSAKNSLRRLNSKYIDLYLIHWPNSSVPLEESIRAMEELVDQGIVNCIGVSNFDVKLLEEAMSLTKKY
EIVANEIEYNVENKSAEKDVIPFCERNNIKVIAYSPLARGNIKNNKILDEIGRKYNRTSVQVALNYLMRRSIPIPKASSK
DHIDEILGALGWNLSDEDYERISKI

Sequences:

>Translated_265_residues
MKLCNKEISQIGFGTWKIGGGYWNPDYSMDSYYIEILKYVISKGINVIDTAEMYGGGHSEELVGKSIQDLDRDGIFIITK
VWSNHLRYDDLIRSAKNSLRRLNSKYIDLYLIHWPNSSVPLEESIRAMEELVDQGIVNCIGVSNFDVKLLEEAMSLTKKY
EIVANEIEYNVENKSAEKDVIPFCERNNIKVIAYSPLARGNIKNNKILDEIGRKYNRTSVQVALNYLMRRSIPIPKASSK
DHIDEILGALGWNLSDEDYERISKI
>Mature_265_residues
MKLCNKEISQIGFGTWKIGGGYWNPDYSMDSYYIEILKYVISKGINVIDTAEMYGGGHSEELVGKSIQDLDRDGIFIITK
VWSNHLRYDDLIRSAKNSLRRLNSKYIDLYLIHWPNSSVPLEESIRAMEELVDQGIVNCIGVSNFDVKLLEEAMSLTKKY
EIVANEIEYNVENKSAEKDVIPFCERNNIKVIAYSPLARGNIKNNKILDEIGRKYNRTSVQVALNYLMRRSIPIPKASSK
DHIDEILGALGWNLSDEDYERISKI

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=267, Percent_Identity=30.7116104868914, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=28.0276816608997, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI45446745, Length=286, Percent_Identity=30.0699300699301, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4503285, Length=286, Percent_Identity=30.0699300699301, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI310109920, Length=286, Percent_Identity=30.0699300699301, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI291291012, Length=266, Percent_Identity=29.3233082706767, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI24497583, Length=287, Percent_Identity=30.3135888501742, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI24497577, Length=297, Percent_Identity=23.2323232323232, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5174391, Length=297, Percent_Identity=23.2323232323232, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5453543, Length=286, Percent_Identity=29.020979020979, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI93277124, Length=306, Percent_Identity=25.8169934640523, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI24497585, Length=282, Percent_Identity=26.9503546099291, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4502049, Length=287, Percent_Identity=30.3135888501742, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=26.1744966442953, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=26.978417266187, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI27436964, Length=208, Percent_Identity=27.4038461538462, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27436962, Length=208, Percent_Identity=27.8846153846154, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI27436966, Length=208, Percent_Identity=27.8846153846154, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI27436969, Length=206, Percent_Identity=27.1844660194175, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4504825, Length=206, Percent_Identity=27.1844660194175, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI223718702, Length=173, Percent_Identity=28.3236994219653, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI27436971, Length=211, Percent_Identity=24.6445497630332, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI41152114, Length=206, Percent_Identity=27.1844660194175, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI41327764, Length=168, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788081, Length=264, Percent_Identity=32.9545454545455, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786400, Length=265, Percent_Identity=30.5660377358491, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI87081735, Length=299, Percent_Identity=28.0936454849498, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788070, Length=305, Percent_Identity=27.5409836065574, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082198, Length=265, Percent_Identity=26.4150943396226, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787674, Length=277, Percent_Identity=25.6317689530686, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789199, Length=236, Percent_Identity=26.6949152542373, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789375, Length=268, Percent_Identity=22.3880597014925, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17550248, Length=299, Percent_Identity=25.752508361204, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71998625, Length=264, Percent_Identity=28.030303030303, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=25, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17552492, Length=278, Percent_Identity=28.0575539568345, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=26.2773722627737, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=26.0416666666667, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561298, Length=278, Percent_Identity=25.8992805755396, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI212645785, Length=209, Percent_Identity=30.622009569378, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=284, Percent_Identity=26.4084507042254, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562292, Length=264, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=22.7118644067797, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17537075, Length=295, Percent_Identity=22.3728813559322, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=29.1095890410959, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=28.8461538461538, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320079, Length=258, Percent_Identity=27.1317829457364, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320576, Length=259, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325169, Length=226, Percent_Identity=27.4336283185841, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321896, Length=310, Percent_Identity=24.8387096774194, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323998, Length=202, Percent_Identity=27.2277227722772, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319958, Length=202, Percent_Identity=26.7326732673267, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319951, Length=196, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657054, Length=256, Percent_Identity=30.859375, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24662789, Length=300, Percent_Identity=28.3333333333333, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21356425, Length=288, Percent_Identity=30.2083333333333, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45553081, Length=284, Percent_Identity=27.112676056338, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20129731, Length=283, Percent_Identity=27.9151943462898, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=28.4210526315789, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281366140, Length=250, Percent_Identity=28.8, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24662781, Length=287, Percent_Identity=30.6620209059233, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24644950, Length=301, Percent_Identity=27.5747508305648, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24662785, Length=286, Percent_Identity=30.4195804195804, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646155, Length=212, Percent_Identity=28.3018867924528, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646159, Length=184, Percent_Identity=29.8913043478261, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640980, Length=253, Percent_Identity=27.6679841897233, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45549126, Length=253, Percent_Identity=27.6679841897233, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30353; Mature: 30353

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCNKEISQIGFGTWKIGGGYWNPDYSMDSYYIEILKYVISKGINVIDTAEMYGGGHSE
CCCHHHHHHHCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCH
ELVGKSIQDLDRDGIFIITKVWSNHLRYDDLIRSAKNSLRRLNSKYIDLYLIHWPNSSVP
HHHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
LEESIRAMEELVDQGIVNCIGVSNFDVKLLEEAMSLTKKYEIVANEIEYNVENKSAEKDV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IPFCERNNIKVIAYSPLARGNIKNNKILDEIGRKYNRTSVQVALNYLMRRSIPIPKASSK
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCH
DHIDEILGALGWNLSDEDYERISKI
HHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKLCNKEISQIGFGTWKIGGGYWNPDYSMDSYYIEILKYVISKGINVIDTAEMYGGGHSE
CCCHHHHHHHCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCH
ELVGKSIQDLDRDGIFIITKVWSNHLRYDDLIRSAKNSLRRLNSKYIDLYLIHWPNSSVP
HHHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
LEESIRAMEELVDQGIVNCIGVSNFDVKLLEEAMSLTKKYEIVANEIEYNVENKSAEKDV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IPFCERNNIKVIAYSPLARGNIKNNKILDEIGRKYNRTSVQVALNYLMRRSIPIPKASSK
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCH
DHIDEILGALGWNLSDEDYERISKI
HHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]