Click here to switch to the map view.

The map label for this gene is pkn2 [H]

Identifier: 227828409

GI number: 227828409

Start: 1971531

End: 1973540

Strand: Direct

Name: pkn2 [H]

Synonym: M1425_2152

Alternate gene names: 227828409

Gene position: 1971531-1973540 (Clockwise)

Preceding gene: 227828408

Following gene: 227828410

Centisome position: 75.57

GC content: 36.07

Gene sequence:

>2010_bases
GTGCAGTTAGTATTACAGTTAGATGATCAGAAATATTTATACGTTGATGGCATAATTAGGCCTTTTGATGGTAAGATAAA
GACTAGAGATGACGTGATAGGTTACGGTGTTATTTATGATGCAGGTAAGGTAAAAGTTTTATACGATTATAAGGTGGTGA
GAGTAAGTGACTTCAGTGTAGTTACACAAGCAATATTGAAGGAAAAAATAGATAATTTGAATATCTATTTGTTTGAAAAC
GGTAATACTATATACGCATATTTTGGAAATGTCCCTAATCCTAAATTAAACTTTCCATACATGATTATACATGGGATACC
TATAGCATTAGGTTCTAAAACTGAGATAATAGAAGCTATAGAAAGGGACTATAGGGTTGCACTATATGCATTAGACAATT
TTAGGAATGACCCTAGCATAGTAAATCATTCTATTTTATCTTTAGTCAAATTTGAGAAATGTGAGGATGCAGTAAAATAT
TATAAGGAACTGAGAGTTTCTGACCCAGAGGTTTCCTTAGCAGTAGCTCAATGTATGGAGAAAATAGGAGAGGAATTGGA
GGCCTTAAAGATTTACTCATTTCTGTCTGAAGAGAAGTATAGGGAGTTGGAGAATAAGATCAGAGGTAAGGTAAACTCAA
TTATTGAGGAGTATAAGAAAGAGGGAAACGTTAAACTCTTAATAGACTCTGTTAAGATGTTACCAACGTATGACGCACCA
CTTATTGAATTAGGCTGGTATTTCGTTAACAAGAGGAAGTTTGATGATGCTGTAAAATACTTCGAGGAAGCTGTTAAAAG
AGTACCTACGTTCCATAATCTGTTGCTATACGCATGGTCTCTTATAAGTAGTGAGAAATATAAGGAGGCATTAGAGGTTA
TTGAGAAGGCGGAAAGGGTTAAGCGGAATGCCGGTTCCGCATACATAAAAGGATTAGCTTTAGAGGGTTTAAATGCCCCA
TCTCAAGCTGAAAGAGAGTTCCTCTATGCGTGTAGGGAAGGGATAATTGATGCGTGTATGAAGATTAGATCGTATAAGCT
TTACGTACCAGAGCCCTTTGATGCTGCAGCTTGGTTAGGTTATGTGCTCTATGGATACGAAGTAAAACAATTGTTGGGAA
ATGGTGGTATGGGTTATGTATTATTAGTTGAGAGGAATGGTAGGAAGTATGCTATGAAAGTGATGAAGAAGGAATATACT
TTTATAGAAATGCTTTATGAAGTTGCTAAAATGCAAGAAATCTCGAAAAGATCTGAATACTTAGTTAAAATATTTGCTAG
TTTTCTAGATGAGAATTGGACAGATTACTTTAGTTCTCCACCCGCAATAATAATGGAATATATGGAAGGGGGTGACTTAA
GGTCAGTCTTAGTCGATCAAGAGTATTCTGCATTACGTCATTCCGTCAAGTGGCCTCAAGTAGTTGCATTCGTGTTCTCT
AAACTCGCAAAAGCCGTTATAGAAGTTCATAAGGAAGGGTATACGCATTGTGACATAAAACCATCTAATATTCTGTTCAA
TAAGAAGCTACCTAGGTACGGAGAAGATGCGCTAAATTCTTTACTCAATTTTGAAGTTGTACCTAAACTATCTGATCTAG
GTTCATCGGTAAAAATAGGTACTCCAGTAATGCATTATACTCCCTATTATGCCCATCCCTTACAGAGATTCGGGAATAAA
GCCGAAACTATGTTCGACGTTTACTCGTTTACAGTATCCCTTTACGTATCTCTCACCAATAACTTTCCATACCCAGAATG
GTTAGAAAATGAAATTGAGGAAGCAGTAAAGAATCCAGAGAAAAGAAAACAAGCCCTGGACGATTTTCATAAAGCAGCAC
CAAGACTTGATTATGTACCAGTGGAATTTAAGGACCTTATAATGAGTGGGCTAAAGGGCGAAGTTAGTATGTTAGAGATA
AACAGGAAACTGGAAGAAATTTTGATTGAAGATTATAACATAGACATTAATAATTCGAACAGTGAAGCAGAAAAGCTTAT
AAGCTATTGA

Upstream 100 bases:

>100_bases
AAGTGTGGTGTCCATAATCTTGCTATAACATGAACTCGTTTTGAACAGGAGGTATTATATGATTTAAGTTACTTAAGATA
TTCCTTTGAACAGAGTTAAT

Downstream 100 bases:

>100_bases
TGACAGTTATATAAAATAAAAGAGTCGGTGAAAAAGAATGATAGAGCCAATGGCTAGGAAAGTGTTCGAAGGACTAGCAT
ATACGATATGGGAAGACGAC

Product: serine/threonine protein kinase with TPR repeats

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MQLVLQLDDQKYLYVDGIIRPFDGKIKTRDDVIGYGVIYDAGKVKVLYDYKVVRVSDFSVVTQAILKEKIDNLNIYLFEN
GNTIYAYFGNVPNPKLNFPYMIIHGIPIALGSKTEIIEAIERDYRVALYALDNFRNDPSIVNHSILSLVKFEKCEDAVKY
YKELRVSDPEVSLAVAQCMEKIGEELEALKIYSFLSEEKYRELENKIRGKVNSIIEEYKKEGNVKLLIDSVKMLPTYDAP
LIELGWYFVNKRKFDDAVKYFEEAVKRVPTFHNLLLYAWSLISSEKYKEALEVIEKAERVKRNAGSAYIKGLALEGLNAP
SQAEREFLYACREGIIDACMKIRSYKLYVPEPFDAAAWLGYVLYGYEVKQLLGNGGMGYVLLVERNGRKYAMKVMKKEYT
FIEMLYEVAKMQEISKRSEYLVKIFASFLDENWTDYFSSPPAIIMEYMEGGDLRSVLVDQEYSALRHSVKWPQVVAFVFS
KLAKAVIEVHKEGYTHCDIKPSNILFNKKLPRYGEDALNSLLNFEVVPKLSDLGSSVKIGTPVMHYTPYYAHPLQRFGNK
AETMFDVYSFTVSLYVSLTNNFPYPEWLENEIEEAVKNPEKRKQALDDFHKAAPRLDYVPVEFKDLIMSGLKGEVSMLEI
NRKLEEILIEDYNIDINNSNSEAEKLISY

Sequences:

>Translated_669_residues
MQLVLQLDDQKYLYVDGIIRPFDGKIKTRDDVIGYGVIYDAGKVKVLYDYKVVRVSDFSVVTQAILKEKIDNLNIYLFEN
GNTIYAYFGNVPNPKLNFPYMIIHGIPIALGSKTEIIEAIERDYRVALYALDNFRNDPSIVNHSILSLVKFEKCEDAVKY
YKELRVSDPEVSLAVAQCMEKIGEELEALKIYSFLSEEKYRELENKIRGKVNSIIEEYKKEGNVKLLIDSVKMLPTYDAP
LIELGWYFVNKRKFDDAVKYFEEAVKRVPTFHNLLLYAWSLISSEKYKEALEVIEKAERVKRNAGSAYIKGLALEGLNAP
SQAEREFLYACREGIIDACMKIRSYKLYVPEPFDAAAWLGYVLYGYEVKQLLGNGGMGYVLLVERNGRKYAMKVMKKEYT
FIEMLYEVAKMQEISKRSEYLVKIFASFLDENWTDYFSSPPAIIMEYMEGGDLRSVLVDQEYSALRHSVKWPQVVAFVFS
KLAKAVIEVHKEGYTHCDIKPSNILFNKKLPRYGEDALNSLLNFEVVPKLSDLGSSVKIGTPVMHYTPYYAHPLQRFGNK
AETMFDVYSFTVSLYVSLTNNFPYPEWLENEIEEAVKNPEKRKQALDDFHKAAPRLDYVPVEFKDLIMSGLKGEVSMLEI
NRKLEEILIEDYNIDINNSNSEAEKLISY
>Mature_669_residues
MQLVLQLDDQKYLYVDGIIRPFDGKIKTRDDVIGYGVIYDAGKVKVLYDYKVVRVSDFSVVTQAILKEKIDNLNIYLFEN
GNTIYAYFGNVPNPKLNFPYMIIHGIPIALGSKTEIIEAIERDYRVALYALDNFRNDPSIVNHSILSLVKFEKCEDAVKY
YKELRVSDPEVSLAVAQCMEKIGEELEALKIYSFLSEEKYRELENKIRGKVNSIIEEYKKEGNVKLLIDSVKMLPTYDAP
LIELGWYFVNKRKFDDAVKYFEEAVKRVPTFHNLLLYAWSLISSEKYKEALEVIEKAERVKRNAGSAYIKGLALEGLNAP
SQAEREFLYACREGIIDACMKIRSYKLYVPEPFDAAAWLGYVLYGYEVKQLLGNGGMGYVLLVERNGRKYAMKVMKKEYT
FIEMLYEVAKMQEISKRSEYLVKIFASFLDENWTDYFSSPPAIIMEYMEGGDLRSVLVDQEYSALRHSVKWPQVVAFVFS
KLAKAVIEVHKEGYTHCDIKPSNILFNKKLPRYGEDALNSLLNFEVVPKLSDLGSSVKIGTPVMHYTPYYAHPLQRFGNK
AETMFDVYSFTVSLYVSLTNNFPYPEWLENEIEEAVKNPEKRKQALDDFHKAAPRLDYVPVEFKDLIMSGLKGEVSMLEI
NRKLEEILIEDYNIDINNSNSEAEKLISY

Specific function: Regulates the activity of endogenous beta-lactamase or related enzymes, by blocking their secretion by phosphorylation, in response to an external signal yet to be identified [H]

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17538163, Length=234, Percent_Identity=27.3504273504274, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325053, Length=162, Percent_Identity=29.0123456790123, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24663340, Length=230, Percent_Identity=30, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR002290 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 77195; Mature: 77195

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION ; PS00107 PROTEIN_KINASE_ATP ; PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLVLQLDDQKYLYVDGIIRPFDGKIKTRDDVIGYGVIYDAGKVKVLYDYKVVRVSDFSV
CEEEEEECCCCEEEECCEEECCCCCCCCCCCEEEEEEEECCCCEEEEEEEEEEEECHHHH
VTQAILKEKIDNLNIYLFENGNTIYAYFGNVPNPKLNFPYMIIHGIPIALGSKTEIIEAI
HHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCEEEEECCCEECCCHHHHHHHH
ERDYRVALYALDNFRNDPSIVNHSILSLVKFEKCEDAVKYYKELRVSDPEVSLAVAQCME
HHCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KIGEELEALKIYSFLSEEKYRELENKIRGKVNSIIEEYKKEGNVKLLIDSVKMLPTYDAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCC
LIELGWYFVNKRKFDDAVKYFEEAVKRVPTFHNLLLYAWSLISSEKYKEALEVIEKAERV
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRNAGSAYIKGLALEGLNAPSQAEREFLYACREGIIDACMKIRSYKLYVPEPFDAAAWLG
HHCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHH
YVLYGYEVKQLLGNGGMGYVLLVERNGRKYAMKVMKKEYTFIEMLYEVAKMQEISKRSEY
HHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVKIFASFLDENWTDYFSSPPAIIMEYMEGGDLRSVLVDQEYSALRHSVKWPQVVAFVFS
HHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHHHHCHHHHHHHHCCCHHHHHHHHHH
KLAKAVIEVHKEGYTHCDIKPSNILFNKKLPRYGEDALNSLLNFEVVPKLSDLGSSVKIG
HHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCHHHCCCCEECC
TPVMHYTPYYAHPLQRFGNKAETMFDVYSFTVSLYVSLTNNFPYPEWLENEIEEAVKNPE
CCCEECCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCHH
KRKQALDDFHKAAPRLDYVPVEFKDLIMSGLKGEVSMLEINRKLEEILIEDYNIDINNSN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEECCCC
SEAEKLISY
HHHHHHHCC
>Mature Secondary Structure
MQLVLQLDDQKYLYVDGIIRPFDGKIKTRDDVIGYGVIYDAGKVKVLYDYKVVRVSDFSV
CEEEEEECCCCEEEECCEEECCCCCCCCCCCEEEEEEEECCCCEEEEEEEEEEEECHHHH
VTQAILKEKIDNLNIYLFENGNTIYAYFGNVPNPKLNFPYMIIHGIPIALGSKTEIIEAI
HHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCEEEEECCCEECCCHHHHHHHH
ERDYRVALYALDNFRNDPSIVNHSILSLVKFEKCEDAVKYYKELRVSDPEVSLAVAQCME
HHCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KIGEELEALKIYSFLSEEKYRELENKIRGKVNSIIEEYKKEGNVKLLIDSVKMLPTYDAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCC
LIELGWYFVNKRKFDDAVKYFEEAVKRVPTFHNLLLYAWSLISSEKYKEALEVIEKAERV
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRNAGSAYIKGLALEGLNAPSQAEREFLYACREGIIDACMKIRSYKLYVPEPFDAAAWLG
HHCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHH
YVLYGYEVKQLLGNGGMGYVLLVERNGRKYAMKVMKKEYTFIEMLYEVAKMQEISKRSEY
HHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVKIFASFLDENWTDYFSSPPAIIMEYMEGGDLRSVLVDQEYSALRHSVKWPQVVAFVFS
HHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHHHHCHHHHHHHHCCCHHHHHHHHHH
KLAKAVIEVHKEGYTHCDIKPSNILFNKKLPRYGEDALNSLLNFEVVPKLSDLGSSVKIG
HHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCHHHCCCCEECC
TPVMHYTPYYAHPLQRFGNKAETMFDVYSFTVSLYVSLTNNFPYPEWLENEIEEAVKNPE
CCCEECCCHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCHH
KRKQALDDFHKAAPRLDYVPVEFKDLIMSGLKGEVSMLEINRKLEEILIEDYNIDINNSN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEECCCC
SEAEKLISY
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7774814 [H]