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The map label for this gene is ddc [H]

Identifier: 227081322

GI number: 227081322

Start: 1177756

End: 1179402

Strand: Reverse

Name: ddc [H]

Synonym: VCM66_1105

Alternate gene names: 227081322

Gene position: 1179402-1177756 (Counterclockwise)

Preceding gene: 227081323

Following gene: 227081321

Centisome position: 40.77

GC content: 48.27

Gene sequence:

>1647_bases
ATGGTATCAGAACACAAATCCGCGCAAGTCAACTTCGATTCTCTGCTCAAGATCTTCACCGTACCGGAAGGTCCAGACTC
AACATTAACTAAAATCGATGAAGAGCTTTCTCGCAATTTAAACCACTTCTTGCGCAAACACATTGTGGCAGAAGAAAAGC
CGCTCAAAGAGATTGAGAAAGATTTTTCCAACGCGCACATTCCCGAACAGCCTCAATTCGTTTCCGATCATACCCAATAT
TTACTGGATACTCTGGTGTCACACTCAGTGCACACCGCATCGCCCAGTTTTATTGGCCACATGACATCGGCACTGCCCTA
CTTCCTGATGCCGCTGTCAAAAATTATGATCGCTCTCAACCAGAATCTGGTCAAAATTGAAACCTCGAAGGCATTCACGC
CGCTAGAGCGTCAAGTGCTAGGCATGATCCATCGCTTGATTTATGGCGAGACGGATCACTTCTATCAACAGTGGATGCAC
AGTGCTGAGCACTCACTCGGCGCTTTCTGCTCAGGCGGAACCATAGCCAACATTACGGCACTTTGGGTTGCTCGTAATAA
TGCGCTTAAAGCAGAAGGCGATTTCCCCGGCGTTGAAAAAGCTGGGCTCTTCAAAGCCATGCGCCACTACGGTCATGAAG
GTTTAGCCATTTTGGTTTCCGAACGAGGCCACTACTCGTTGAAAAAAGCGGCCGATGTGCTGGGTATAGGCCAAGAAGGC
TTGGTCGCGGTCAAAACCGATGCGCATAACCGTATCTGCCCACACGATCTAGAGCAGAAAATCACCGAGTTAAAAGCCAA
TAAGATCAAAGTGTTTGCCGTTGTCGGAGTCGCCGGCACCACAGAAACCGGCAATATTGACCCACTGCGCACCATTGCTC
AGATTTGTCAGCGTGAACAGATCCACTTCCATATCGATGCGGCTTGGGGCGGCGCGACGTTAATGTCAAACCGTTATCGA
GGACTGCTTGATGGTGTCGAGTTGGCCGATTCAGTGACCATTGATGCTCATAAGCAGCTCTACATCCCTATGGGTGCGGG
TATGGTCTTGTTTAAAGACCCGAATGCGATGCGCTCAATTGAGCATCATGCCCAGTACATTTTGCGTCAAGGCTCTAAAG
ATTTGGGTAGCCATACCCTAGAAGGATCACGCTCAGGCATGGCGATGTTGGTTTACGCCAGCATGCACATCATTAGCCGC
CCAGGCTATCAGCTACTTATCGATCAAAGTATTGAAAAAGCGCGATATTTTGCCGACCTGATTGATGCGCAAACTGACTT
TGAGTTGGTTTCGCAACCGGAACTCTGCTTGTTGACTTATCGCTATCTACCCGAGCATGTCCGCATGGCGCTAGAAAAAT
CGCAAGGGGTACAGCGTGCGCAGTTGAATGAGCTACTGAACGAACTCACTAAGTTTATTCAGAAGAAACAAAGGGAAACG
GGTAAATCCTTTGTGTCACGTACCCAACTCAATCCACACCAATGGGATAAATTGGCAACCATAGTCTTCCGAGTGGTATT
GGCCAACCCGCTGACGACCAAAGAAATTTTGCATAACGTGCTGGATGAACAACGAGAAATCGCGCAACAAGCGCCAAAGT
TGATGCGTCAAATCGAACATCTAACCCAATGCATTCTGAACCAATAA

Upstream 100 bases:

>100_bases
AATGCAATCAAGGCTTTCCGAATTAAGACGGGACATTGTTCCCGTTTTGAATTAGATTGTCCCGCTTGAAGCCCATCAAT
CAGAATAATAACGACGCTGT

Downstream 100 bases:

>100_bases
TCCTTCGCTAAGAGTTACAGCAAACAGAAATAAAATTTCAGTTTGCTGTAACTCTTGCGTCAATCATGGGCTAGAAGCAC
CAGATATGGGCAACACCACA

Product: putative glutamate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MVSEHKSAQVNFDSLLKIFTVPEGPDSTLTKIDEELSRNLNHFLRKHIVAEEKPLKEIEKDFSNAHIPEQPQFVSDHTQY
LLDTLVSHSVHTASPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMIHRLIYGETDHFYQQWMH
SAEHSLGAFCSGGTIANITALWVARNNALKAEGDFPGVEKAGLFKAMRHYGHEGLAILVSERGHYSLKKAADVLGIGQEG
LVAVKTDAHNRICPHDLEQKITELKANKIKVFAVVGVAGTTETGNIDPLRTIAQICQREQIHFHIDAAWGGATLMSNRYR
GLLDGVELADSVTIDAHKQLYIPMGAGMVLFKDPNAMRSIEHHAQYILRQGSKDLGSHTLEGSRSGMAMLVYASMHIISR
PGYQLLIDQSIEKARYFADLIDAQTDFELVSQPELCLLTYRYLPEHVRMALEKSQGVQRAQLNELLNELTKFIQKKQRET
GKSFVSRTQLNPHQWDKLATIVFRVVLANPLTTKEILHNVLDEQREIAQQAPKLMRQIEHLTQCILNQ

Sequences:

>Translated_548_residues
MVSEHKSAQVNFDSLLKIFTVPEGPDSTLTKIDEELSRNLNHFLRKHIVAEEKPLKEIEKDFSNAHIPEQPQFVSDHTQY
LLDTLVSHSVHTASPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMIHRLIYGETDHFYQQWMH
SAEHSLGAFCSGGTIANITALWVARNNALKAEGDFPGVEKAGLFKAMRHYGHEGLAILVSERGHYSLKKAADVLGIGQEG
LVAVKTDAHNRICPHDLEQKITELKANKIKVFAVVGVAGTTETGNIDPLRTIAQICQREQIHFHIDAAWGGATLMSNRYR
GLLDGVELADSVTIDAHKQLYIPMGAGMVLFKDPNAMRSIEHHAQYILRQGSKDLGSHTLEGSRSGMAMLVYASMHIISR
PGYQLLIDQSIEKARYFADLIDAQTDFELVSQPELCLLTYRYLPEHVRMALEKSQGVQRAQLNELLNELTKFIQKKQRET
GKSFVSRTQLNPHQWDKLATIVFRVVLANPLTTKEILHNVLDEQREIAQQAPKLMRQIEHLTQCILNQ
>Mature_548_residues
MVSEHKSAQVNFDSLLKIFTVPEGPDSTLTKIDEELSRNLNHFLRKHIVAEEKPLKEIEKDFSNAHIPEQPQFVSDHTQY
LLDTLVSHSVHTASPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMIHRLIYGETDHFYQQWMH
SAEHSLGAFCSGGTIANITALWVARNNALKAEGDFPGVEKAGLFKAMRHYGHEGLAILVSERGHYSLKKAADVLGIGQEG
LVAVKTDAHNRICPHDLEQKITELKANKIKVFAVVGVAGTTETGNIDPLRTIAQICQREQIHFHIDAAWGGATLMSNRYR
GLLDGVELADSVTIDAHKQLYIPMGAGMVLFKDPNAMRSIEHHAQYILRQGSKDLGSHTLEGSRSGMAMLVYASMHIISR
PGYQLLIDQSIEKARYFADLIDAQTDFELVSQPELCLLTYRYLPEHVRMALEKSQGVQRAQLNELLNELTKFIQKKQRET
GKSFVSRTQLNPHQWDKLATIVFRVVLANPLTTKEILHNVLDEQREIAQQAPKLMRQIEHLTQCILNQ

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=477, Percent_Identity=27.4633123689727, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI4503875, Length=477, Percent_Identity=27.4633123689727, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI197383062, Length=451, Percent_Identity=28.159645232816, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI194294551, Length=453, Percent_Identity=27.3730684326711, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI58331246, Length=471, Percent_Identity=26.963906581741, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4503281, Length=384, Percent_Identity=21.3541666666667, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI132814448, Length=384, Percent_Identity=21.3541666666667, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI92110055, Length=358, Percent_Identity=23.7430167597765, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17555682, Length=473, Percent_Identity=27.061310782241, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71993062, Length=451, Percent_Identity=27.0509977827051, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71993058, Length=390, Percent_Identity=28.2051282051282, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17534819, Length=280, Percent_Identity=24.6428571428571, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17534817, Length=280, Percent_Identity=24.6428571428571, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71981211, Length=351, Percent_Identity=21.3675213675214, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136594, Length=465, Percent_Identity=26.6666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24657193, Length=450, Percent_Identity=27.3333333333333, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24657185, Length=450, Percent_Identity=27.3333333333333, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24657188, Length=450, Percent_Identity=27.3333333333333, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356415, Length=520, Percent_Identity=24.2307692307692, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221476190, Length=428, Percent_Identity=21.7289719626168, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585143, Length=428, Percent_Identity=21.7289719626168, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585139, Length=428, Percent_Identity=21.7289719626168, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652373, Length=396, Percent_Identity=23.4848484848485, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 61694; Mature: 61694

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEHKSAQVNFDSLLKIFTVPEGPDSTLTKIDEELSRNLNHFLRKHIVAEEKPLKEIEK
CCCCCCCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DFSNAHIPEQPQFVSDHTQYLLDTLVSHSVHTASPSFIGHMTSALPYFLMPLSKIMIALN
HHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMIHRLIYGETDHFYQQWMHSAEHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCHHHEEE
LWVARNNALKAEGDFPGVEKAGLFKAMRHYGHEGLAILVSERGHYSLKKAADVLGIGQEG
EEEEECCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
LVAVKTDAHNRICPHDLEQKITELKANKIKVFAVVGVAGTTETGNIDPLRTIAQICQREQ
EEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCC
IHFHIDAAWGGATLMSNRYRGLLDGVELADSVTIDAHKQLYIPMGAGMVLFKDPNAMRSI
EEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCEEEEECCHHHHHH
EHHAQYILRQGSKDLGSHTLEGSRSGMAMLVYASMHIISRPGYQLLIDQSIEKARYFADL
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
IDAQTDFELVSQPELCLLTYRYLPEHVRMALEKSQGVQRAQLNELLNELTKFIQKKQRET
HCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GKSFVSRTQLNPHQWDKLATIVFRVVLANPLTTKEILHNVLDEQREIAQQAPKLMRQIEH
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQCILNQ
HHHHHCCC
>Mature Secondary Structure
MVSEHKSAQVNFDSLLKIFTVPEGPDSTLTKIDEELSRNLNHFLRKHIVAEEKPLKEIEK
CCCCCCCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DFSNAHIPEQPQFVSDHTQYLLDTLVSHSVHTASPSFIGHMTSALPYFLMPLSKIMIALN
HHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMIHRLIYGETDHFYQQWMHSAEHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCHHHEEE
LWVARNNALKAEGDFPGVEKAGLFKAMRHYGHEGLAILVSERGHYSLKKAADVLGIGQEG
EEEEECCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
LVAVKTDAHNRICPHDLEQKITELKANKIKVFAVVGVAGTTETGNIDPLRTIAQICQREQ
EEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCC
IHFHIDAAWGGATLMSNRYRGLLDGVELADSVTIDAHKQLYIPMGAGMVLFKDPNAMRSI
EEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCEEEEECCHHHHHH
EHHAQYILRQGSKDLGSHTLEGSRSGMAMLVYASMHIISRPGYQLLIDQSIEKARYFADL
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
IDAQTDFELVSQPELCLLTYRYLPEHVRMALEKSQGVQRAQLNELLNELTKFIQKKQRET
HCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GKSFVSRTQLNPHQWDKLATIVFRVVLANPLTTKEILHNVLDEQREIAQQAPKLMRQIEH
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQCILNQ
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]