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The map label for this gene is hexR [H]

Identifier: 227081321

GI number: 227081321

Start: 1176594

End: 1177448

Strand: Reverse

Name: hexR [H]

Synonym: VCM66_1104

Alternate gene names: 227081321

Gene position: 1177448-1176594 (Counterclockwise)

Preceding gene: 227081322

Following gene: 227081319

Centisome position: 40.71

GC content: 46.32

Gene sequence:

>855_bases
ATGAATACATTAGAAAAAATTCAAAAAAACCTGGAAAACTTTAGCAAGTCTGAGCGTAAGGTTGCCGAAGTGATTATGGC
ATCACCACAAACCGCTATTCATTCCAGCATTGCTACACTGGCGAAAATGGCGGACGTGAGTGAACCTACGGTGAACCGTT
TCTGTCGCCGCCTTGATACCAAAGGTTTTCCGGACTTTAAACTGCATTTAGCTCAAAGCCTTGCAAACGGCACGCCTTAC
GTTAACCGTAACGTAGAAGAGGATGATGGCCCAGATGCTTACACCCACAAGATTTTCGAATCGACTATGGCGTGTCTGGA
TGTGGCGAAAAACAGTTTGGATCCCGTGCAAATCAACCGTGCTGTTGACCTGCTCACTCAAGCAAAACGTATTTCGTTTT
TTGGCTTAGGCGCGTCCTCTGCGGTCGCACGCGATGCACAGAATAAATTTATCCGCTTCAATATTCCGATCAGCTGCTTT
GAAGATATTGTGATGCAGCGAATGAGCTGTATCAACTGCACCGATAATGATGTGATTGTGCTGATTTCTCATACTGGCCG
TACCAAAAGTCAGGTTGAAATCGCCAATCTTGCTCGTGAAAACGGAGCAACGGTGATCGCGATTACCGCTAAAGATTCAC
CACTGGACAAAGCCAGTTCATTATCGATCTGCTTAGATGTGCCTGAAGACACAGACGTGTATATGCCAATGGCAAGTCGC
GTAGTGCAAATGACCGTGATCGATGTATTGGCAACCGGCTTTACATTGCGCCGAGGTTCAGGCTTTAGAGAAAATCTCAA
GCGCGTGAAAGAAGTGCTGAAAGATTCTCGCTACGACAAACTGCCGCCTTACTAG

Upstream 100 bases:

>100_bases
TATTGGCGTTGGTGGGTTTAGCATTTGGAAGCCATTGATTTCTCCCCTATTGTTTCCAAAGCCCAGACCAACGAGTTGTT
CTCTAGCCTGCGTGAACACT

Downstream 100 bases:

>100_bases
GCCACACACAAAGACAGAATAACGGAGCCCAGTGGCTCCGTTTTCATTTTGAGTCAGAATAATGATGGTTTCCAATAAGG
AGGAATAGGCTCAATGTTGC

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDPVQINRAVDLLTQAKRISFFGLGASSAVARDAQNKFIRFNIPISCF
EDIVMQRMSCINCTDNDVIVLISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSICLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGSGFRENLKRVKEVLKDSRYDKLPPY

Sequences:

>Translated_284_residues
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDPVQINRAVDLLTQAKRISFFGLGASSAVARDAQNKFIRFNIPISCF
EDIVMQRMSCINCTDNDVIVLISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSICLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGSGFRENLKRVKEVLKDSRYDKLPPY
>Mature_284_residues
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY
VNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDPVQINRAVDLLTQAKRISFFGLGASSAVARDAQNKFIRFNIPISCF
EDIVMQRMSCINCTDNDVIVLISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSICLDVPEDTDVYMPMASR
VVQMTVIDVLATGFTLRRGSGFRENLKRVKEVLKDSRYDKLPPY

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=72.1428571428571, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=24.5833333333333, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=26.3358778625954, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI87082130, Length=214, Percent_Identity=28.0373831775701, Blast_Score=88, Evalue=5e-19,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31525; Mature: 31525

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDPVQINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVDLLTQAKRISFFGLGASSAVARDAQNKFIRFNIPISCFEDIVMQRMSCINCTDNDVIV
HHHHHHHHHHHHEEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSICLDVPEDTDVYMPMASR
EEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCEEHHHHHH
VVQMTVIDVLATGFTLRRGSGFRENLKRVKEVLKDSRYDKLPPY
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNTLEKIQKNLENFSKSERKVAEVIMASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
KGFPDFKLHLAQSLANGTPYVNRNVEEDDGPDAYTHKIFESTMACLDVAKNSLDPVQINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AVDLLTQAKRISFFGLGASSAVARDAQNKFIRFNIPISCFEDIVMQRMSCINCTDNDVIV
HHHHHHHHHHHHEEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEE
LISHTGRTKSQVEIANLARENGATVIAITAKDSPLDKASSLSICLDVPEDTDVYMPMASR
EEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCEEHHHHHH
VVQMTVIDVLATGFTLRRGSGFRENLKRVKEVLKDSRYDKLPPY
HHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]