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The map label for this gene is pgi [H]

Identifier: 227080586

GI number: 227080586

Start: 374613

End: 376265

Strand: Direct

Name: pgi [H]

Synonym: VCM66_0358

Alternate gene names: 227080586

Gene position: 374613-376265 (Clockwise)

Preceding gene: 227080584

Following gene: 227080588

Centisome position: 12.95

GC content: 48.88

Gene sequence:

>1653_bases
ATGTTGAAAAATATCAATCCAACGCAAACCCAAGCTTGGAAAGCGCTGACCGCGCATTTTGAATCTGCTCAGGATATGGA
CCTCAAAGCACTTTTTGCGCAAGACAGCGAGCGTTTTGCCAAATACTCTGCGCGCTTTGGTCAGGACATTCTGGTCGATT
ATTCGAAAAACCTAGTGAATGCGGAAACGATGCAACACTTGTTTGCGTTGGCTAAAGAAACGGATCTGCAATCTGCCATC
ACCGCGATGTTTAAAGGTGAAGCGATCAACCAAACGGAAGATCGTGCGGTACTGCACACTGCGCTGCGTAATCGTAGCAA
TTCACCTGTGTTGGTGAACGGTGAGGATGTAATGCCTGCAGTAAACGCTGTGTTGGCTAAAATGAAAGCCTTCTCTGAGC
GTGTGATTGGCGGTGAGTGGAAAGGTTTCACCGGCAAGGCGATTACTGATGTCGTTAATATCGGCATTGGTGGCTCCGAT
CTCGGTCCTTACATGGTCACAGAAGCTCTGGTGCCTTATAAGAACCATTTGACCATGCACTTTGTGTCAAACGTCGATGG
TACACACATGGCGGAGACACTGAAAAACGTCGATCCTGAAACCACCCTCTTCTTAGTGGCTTCCAAAACTTTCACTACCC
AAGAAACCATGACCAACGCCCACACGGCTCGTGATTGGTTCTTGAAAGCGGCAGGAGATGAAGCACATGTTGCTAAGCAC
TTTGCGGCGCTATCAACCAATGGTAAAGCGGTGGCTGAGTTTGGTATCGACACCGACAACATGTTTGAATTCTGGGATTG
GGTAGGCGGTCGTTACTCACTGTGGTCAGCGATTGGTCTTTCTATCATTCTGTCTATCGGTTACGACAACTTTGTTGAGC
TGCTGGCGGGGGCGCATGAAATGGATCAGCATTTCGTGAACACGCCGTTTGAAAGTAATATTCCGGTCATTCTGGCGCTG
ATTGGCATTTGGTATAACAACTTCCATGGTGCTGAATCTGAAGCGATCCTGCCTTACGATCAGTACCTGCATCGCTTCGC
GGCTTACTTCCAACAAGGCAATATGGAGTCTAATGGTAAGTATGTTGATCGTAATGGCAACCCAGTCACTTACCAAACGG
GCCCAATCATTTGGGGTGAACCCGGTACGAACGGCCAGCACGCTTTCTATCAGCTTATCCACCAAGGCACTAAGCTGATC
CCATGTGATTTTATCGCGCCAGCGGTGAGTCATAATTTGGTTGGCGATCATCACCAAAAGCTGATGTCTAACTTCTTCGC
GCAAACCGAAGCCTTAGCCTTCGGAAAATCCGCGCAAGCCGTGCAAGCTGAACTCGAAAAAGCGGGTAAATCGGCGGCAG
AAATTGCAGCGTTAGTGCCGTTCAAAGTGTTTGAAGGTAACCGCCCAACCAACTCGATTCTGGTTAAGCAGATTACGCCA
CGCACGCTGGGTAACTTGATTGCGATGTACGAACACAAAATCTTCGTACAAGGTGTGATTTGGAACATCTTCAGTTTCGA
TCAATGGGGCGTGGAACTGGGTAAGCAACTGGCGAACCAAATCCTGCCTGAGTTAGCGGATAGCGCAGCCGTGACGTCAC
ATGACAGCTCGACCAACGGTCTGATCAACGCCTTTAAAGCGTTTCGCGCCTAA

Upstream 100 bases:

>100_bases
ATTTTTAACCTATTCTTTTTGCTTAAATCGGGGATTCCAACGTTAAAGCTCCGCCTTTAGCGTACTGGAATAAAACCACA
GTAACATCGGGATAGATGCC

Downstream 100 bases:

>100_bases
TTACGCCGAATAACCAATTGATAGACAAGGTCTTACCTGTGCAGTAAGGCCTTTTTCTTGTCTTTGAGTTTCTCTGTACG
TGGCGAAGTCCCTTCTTTGT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLKNINPTQTQAWKALTAHFESAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVNAETMQHLFALAKETDLQSAI
TAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPAVNAVLAKMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSD
LGPYMVTEALVPYKNHLTMHFVSNVDGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKH
FAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHEMDQHFVNTPFESNIPVILAL
IGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGKYVDRNGNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAVSHNLVGDHHQKLMSNFFAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITP
RTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNGLINAFKAFRA

Sequences:

>Translated_550_residues
MLKNINPTQTQAWKALTAHFESAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVNAETMQHLFALAKETDLQSAI
TAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPAVNAVLAKMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSD
LGPYMVTEALVPYKNHLTMHFVSNVDGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKH
FAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHEMDQHFVNTPFESNIPVILAL
IGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGKYVDRNGNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAVSHNLVGDHHQKLMSNFFAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITP
RTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNGLINAFKAFRA
>Mature_550_residues
MLKNINPTQTQAWKALTAHFESAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVNAETMQHLFALAKETDLQSAI
TAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPAVNAVLAKMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSD
LGPYMVTEALVPYKNHLTMHFVSNVDGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKH
FAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHEMDQHFVNTPFESNIPVILAL
IGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGKYVDRNGNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAVSHNLVGDHHQKLMSNFFAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITP
RTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNGLINAFKAFRA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=535, Percent_Identity=64.1121495327103, Blast_Score=717, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=535, Percent_Identity=60, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=77.0491803278689, Blast_Score=907, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=62.3636363636364, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=62.7522935779817, Blast_Score=700, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=59.963436928702, Blast_Score=645, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=546, Percent_Identity=65.018315018315, Blast_Score=725, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=546, Percent_Identity=65.018315018315, Blast_Score=725, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=546, Percent_Identity=65.018315018315, Blast_Score=725, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 60691; Mature: 60691

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNINPTQTQAWKALTAHFESAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVN
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCC
AETMQHLFALAKETDLQSAITAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHH
VNAVLAKMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSDLGPYMVTEALVPYKNHLTMH
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCHHCCEEEE
FVSNVDGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKH
EECCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHE
HHHHCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCHHH
MDQHFVNTPFESNIPVILALIGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGK
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
YVDRNGNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAVSHNLVGDHHQK
EEECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHH
LMSNFFAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCHHEECCCCCCCCEEEECCCH
RTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHH
LINAFKAFRA
HHHHHHHHCC
>Mature Secondary Structure
MLKNINPTQTQAWKALTAHFESAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVN
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCC
AETMQHLFALAKETDLQSAITAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHH
VNAVLAKMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSDLGPYMVTEALVPYKNHLTMH
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCHHCCEEEE
FVSNVDGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKH
EECCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FAALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHE
HHHHCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCHHH
MDQHFVNTPFESNIPVILALIGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGK
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
YVDRNGNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAVSHNLVGDHHQK
EEECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHH
LMSNFFAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCHHEECCCCCCCCEEEECCCH
RTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHH
LINAFKAFRA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA