Click here to switch to the map view.

The map label for this gene is galE [C]

Identifier: 226950090

GI number: 226950090

Start: 3041513

End: 3042430

Strand: Reverse

Name: galE [C]

Synonym: CLM_3043

Alternate gene names: 226950090

Gene position: 3042430-3041513 (Counterclockwise)

Preceding gene: 226950091

Following gene: 226950089

Centisome position: 73.22

GC content: 28.1

Gene sequence:

>918_bases
ATGAAAATATTAGTTACTGGTGGAGCAGGGTTTATAGCATCGAATTTAGTAGATAAACTTATAAGCATGGGAAATGATGT
ATGTATAATTGATAATTTATCCACTGGAAATATAAATAATGTAAATAAAAAAGCTAGATTATATATAAATGATATATTAG
ATTCTAATATATCTAGCATATTTAAAAAAGAAAGGTTTGATATAGTTTATCATTTTGCTGCTCAAATCGATGTGCAAAAA
TCCATAAAAGATCCTATGTTTGATTCTAATGTAAATATATGTGGCACCGTGAATATATTAAAAAGTTGTGTTGATTATGG
CGTTAAGAAGATAATATATCCTTCTTCAGCAGCAGTTTATGGACAACCAGAATATTTACCTATAGATGAAAAACATAGGG
TAAAACCCATATCTTCTTATGGATTATCAAAATATACACCAGAAGAATATATAAGGTCCTTTAGTGAATTATATAACTTG
GATTATACCATATTTAGATATGCTAATGTTTATGGTATAAGACAAGATCCTAAGGGTGAAGGTGGAGTAGTATCTATATT
TATGGATAGATTATTTAAAAATTATCCCCTATGTATATTCGGAGATGGAAAGGCTTTGAGAGATTATATATATGTAGAAG
ATGTAGTAAATGCTAATATTGCCGCCTTATGTAATGGTAGTAGAAATCTATTTAATATAGGTACCGGTGTTTATACTACT
GTTAAAGATTTAGCTCAAATGATGATAGACACTATGAAAGTTCAATCTCATATAGAGTACCAAGAGGCTAGAAAAGGAGA
TATAGAGAAATCTTATTTTAATATAGAGAAGGCTAAAGTGGAACTTAAGTGGGAACCAAAATATAATTTACAAAAGGGGC
TTATAAAAACTATAAATTATTATAAAGACAATATATAG

Upstream 100 bases:

>100_bases
GATAGGATATTAGGTAGACAAGTAAAAGTTAATATAGAAGAGGATACCATATTAACTTGGGAATTATTTTAATTATTATT
TTAAAAGAGGATGATTAACT

Downstream 100 bases:

>100_bases
GATAATGCTTATTTAAAAGTATTACATAAGGTGATAAATATGTTAACAAAATTTAAAAATATATTTAAAAACAATAAGTT
TAATGTGATTTTCAAATATT

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKILVTGGAGFIASNLVDKLISMGNDVCIIDNLSTGNINNVNKKARLYINDILDSNISSIFKKERFDIVYHFAAQIDVQK
SIKDPMFDSNVNICGTVNILKSCVDYGVKKIIYPSSAAVYGQPEYLPIDEKHRVKPISSYGLSKYTPEEYIRSFSELYNL
DYTIFRYANVYGIRQDPKGEGGVVSIFMDRLFKNYPLCIFGDGKALRDYIYVEDVVNANIAALCNGSRNLFNIGTGVYTT
VKDLAQMMIDTMKVQSHIEYQEARKGDIEKSYFNIEKAKVELKWEPKYNLQKGLIKTINYYKDNI

Sequences:

>Translated_305_residues
MKILVTGGAGFIASNLVDKLISMGNDVCIIDNLSTGNINNVNKKARLYINDILDSNISSIFKKERFDIVYHFAAQIDVQK
SIKDPMFDSNVNICGTVNILKSCVDYGVKKIIYPSSAAVYGQPEYLPIDEKHRVKPISSYGLSKYTPEEYIRSFSELYNL
DYTIFRYANVYGIRQDPKGEGGVVSIFMDRLFKNYPLCIFGDGKALRDYIYVEDVVNANIAALCNGSRNLFNIGTGVYTT
VKDLAQMMIDTMKVQSHIEYQEARKGDIEKSYFNIEKAKVELKWEPKYNLQKGLIKTINYYKDNI
>Mature_305_residues
MKILVTGGAGFIASNLVDKLISMGNDVCIIDNLSTGNINNVNKKARLYINDILDSNISSIFKKERFDIVYHFAAQIDVQK
SIKDPMFDSNVNICGTVNILKSCVDYGVKKIIYPSSAAVYGQPEYLPIDEKHRVKPISSYGLSKYTPEEYIRSFSELYNL
DYTIFRYANVYGIRQDPKGEGGVVSIFMDRLFKNYPLCIFGDGKALRDYIYVEDVVNANIAALCNGSRNLFNIGTGVYTT
VKDLAQMMIDTMKVQSHIEYQEARKGDIEKSYFNIEKAKVELKWEPKYNLQKGLIKTINYYKDNI

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=309, Percent_Identity=28.4789644012945, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI7657641, Length=321, Percent_Identity=32.398753894081, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI56237023, Length=339, Percent_Identity=31.2684365781711, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI56118217, Length=339, Percent_Identity=31.2684365781711, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI189083684, Length=339, Percent_Identity=31.2684365781711, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1786974, Length=316, Percent_Identity=29.1139240506329, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790049, Length=268, Percent_Identity=32.4626865671642, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=28.5294117647059, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994969, Length=335, Percent_Identity=26.865671641791, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788589, Length=337, Percent_Identity=22.5519287833828, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788365, Length=328, Percent_Identity=19.8170731707317, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788366, Length=276, Percent_Identity=23.1884057971014, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=310, Percent_Identity=27.741935483871, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=28.695652173913, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=28.5302593659942, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17568069, Length=323, Percent_Identity=28.7925696594427, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI115532424, Length=323, Percent_Identity=27.5541795665635, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319493, Length=328, Percent_Identity=31.4024390243902, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356223, Length=314, Percent_Identity=28.6624203821656, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI19923002, Length=339, Percent_Identity=28.6135693215339, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34670; Mature: 34670

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGGAGFIASNLVDKLISMGNDVCIIDNLSTGNINNVNKKARLYINDILDSNISSI
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHEEEEHHHHHHHHHHH
FKKERFDIVYHFAAQIDVQKSIKDPMFDSNVNICGTVNILKSCVDYGVKKIIYPSSAAVY
HHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCHHHEECCCCCEEC
GQPEYLPIDEKHRVKPISSYGLSKYTPEEYIRSFSELYNLDYTIFRYANVYGIRQDPKGE
CCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHEEEECCCCCCC
GGVVSIFMDRLFKNYPLCIFGDGKALRDYIYVEDVVNANIAALCNGSRNLFNIGTGVYTT
CCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCHHHH
VKDLAQMMIDTMKVQSHIEYQEARKGDIEKSYFNIEKAKVELKWEPKYNLQKGLIKTINY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEEEEEECCCCCHHHHHHHHHHH
YKDNI
HHCCC
>Mature Secondary Structure
MKILVTGGAGFIASNLVDKLISMGNDVCIIDNLSTGNINNVNKKARLYINDILDSNISSI
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHEEEEHHHHHHHHHHH
FKKERFDIVYHFAAQIDVQKSIKDPMFDSNVNICGTVNILKSCVDYGVKKIIYPSSAAVY
HHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCHHHEECCCCCEEC
GQPEYLPIDEKHRVKPISSYGLSKYTPEEYIRSFSELYNLDYTIFRYANVYGIRQDPKGE
CCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHEEEECCCCCCC
GGVVSIFMDRLFKNYPLCIFGDGKALRDYIYVEDVVNANIAALCNGSRNLFNIGTGVYTT
CCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCHHHH
VKDLAQMMIDTMKVQSHIEYQEARKGDIEKSYFNIEKAKVELKWEPKYNLQKGLIKTINY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEEEEEECCCCCHHHHHHHHHHH
YKDNI
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]