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The map label for this gene is patB [H]

Identifier: 226949262

GI number: 226949262

Start: 2240218

End: 2241387

Strand: Reverse

Name: patB [H]

Synonym: CLM_2181

Alternate gene names: 226949262

Gene position: 2241387-2240218 (Counterclockwise)

Preceding gene: 226949266

Following gene: 226949261

Centisome position: 53.94

GC content: 40.43

Gene sequence:

>1170_bases
ATGAAATATGATTTTGATGAAATCATTGACCGCAGCAATAATCGTGCAGCAAAGTATGATGAACGGGTGAAAAAATTCGG
TACCAGTGAAGTGATTCCTTTGTGGATTGCGGATATGGATTTCAGAACTGCTCAACCAATCATCGATGCTTGCAAAAGAA
AAGCAGAGGAAGGCGTCTGGGGTTATACTTCCAGGCCGGACAGCTACTTTAAGGCCGTACAGGAATGGGAAAAAAGGCGG
AATCAATGGGATGTTGATGTATCCCTGATGAGCTGGAGCTTAGGGGTTGTTCCTGCATTATCGGCTATTGTGAAAATTTT
CAGCCACACTGGCGACAAAATTTTGATTCAGACTCCGGTTTATTCAGAGTTTTATGATATCACAGAGGCTTGGGCACGAG
TAGTGGTAGAAAACCAGTTCATAGAAAAAAATGGAAAGTGGCATATTGATTTTGAGGATTTTGAAAAAAAGGCAAAAGAG
TGTAAGATTTTTCTTCTATGTAATCCCCACAATCCACTGGGCATTGTATGGGAGCCGGAGGAATTAAAACGGATGGCGGA
AATATGCATTGCAAATGATGTGCTTCTGGTGTCAGATGAGATACACTCAGATTTAATTTTCCATGGAAAGAAGCATACGC
CTACAGCAACACTTTCCAAAGAAATTTCAAAAAAAATTATTACCTGTGTATCTGCAACTAAAACTTTCAACCTAGCAGGT
CTTCAAGCTTCTACGACTATCTTTCCAAATGAACAGATGAAGCAGAAGTTCGATGGTTTCTGGATGAATATGGATATTCA
AAGAAACAATGCCTTTAGCTCAGTGGCCATGGAAGCAGCTTACAATGAAGGCGAGGAGTGGCTGACACAGCTACTTGCTT
ACGTCTCAGAAAACTTTGATTTTATTAAAAAATATTTTGATGAAAACATTCCAAAAATCAAGCCTAATGTTCCAGATGCT
ACATATCTGGTCTGGCTGGACTGCCGAGAATTAGGCATGAGCAATGAAGAGCTCCGTGACTTCATGATTCATAAGGTTGG
TTTAGGCTTAAATGAAGGATGTAGTTTTGGACGCAGCCTTTCCGGATACATGAGACTTAATGCAGCATGCCCGCGCTCTG
TACTGGAACAGGCATTGAAACAGTTAAAAGAAGCAATCGATAAATTATAA

Upstream 100 bases:

>100_bases
TTTTGTTTAAAAATGCAAAAAAAATTTTTGGCATGGTTTTTGCTCATTATATTAGTATCAACTGTAAACAACAAGAACAG
TGAGGAAAGGAAGATTTATT

Downstream 100 bases:

>100_bases
AATATAAAAGTTGGGGTTTTTATGAAATGCTGGAAAGGAGAAAATATGGGGAAGAAGAAAATATGGGAGAGTTATCGATC
TCCACTCATTTTGCTTGGGG

Product: class I/II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRR
NQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPVYSEFYDITEAWARVVVENQFIEKNGKWHIDFEDFEKKAKE
CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEISKKIITCVSATKTFNLAG
LQASTTIFPNEQMKQKFDGFWMNMDIQRNNAFSSVAMEAAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDA
TYLVWLDCRELGMSNEELRDFMIHKVGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL

Sequences:

>Translated_389_residues
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRR
NQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPVYSEFYDITEAWARVVVENQFIEKNGKWHIDFEDFEKKAKE
CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEISKKIITCVSATKTFNLAG
LQASTTIFPNEQMKQKFDGFWMNMDIQRNNAFSSVAMEAAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDA
TYLVWLDCRELGMSNEELRDFMIHKVGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL
>Mature_389_residues
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVWGYTSRPDSYFKAVQEWEKRR
NQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPVYSEFYDITEAWARVVVENQFIEKNGKWHIDFEDFEKKAKE
CKIFLLCNPHNPLGIVWEPEELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEISKKIITCVSATKTFNLAG
LQASTTIFPNEQMKQKFDGFWMNMDIQRNNAFSSVAMEAAYNEGEEWLTQLLAYVSENFDFIKKYFDENIPKIKPNVPDA
TYLVWLDCRELGMSNEELRDFMIHKVGLGLNEGCSFGRSLSGYMRLNAACPRSVLEQALKQLKEAIDKL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=284, Percent_Identity=27.112676056338, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI56713254, Length=284, Percent_Identity=27.112676056338, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI95147551, Length=259, Percent_Identity=22.7799227799228, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169881279, Length=259, Percent_Identity=22.7799227799228, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169881281, Length=207, Percent_Identity=23.1884057971014, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=30.4123711340206, Blast_Score=224, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6322401, Length=142, Percent_Identity=32.3943661971831, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28573069, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646114, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573067, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573065, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18859735, Length=388, Percent_Identity=20.8762886597938, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44851; Mature: 44851

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVW
CCCCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
GYTSRPDSYFKAVQEWEKRRNQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPV
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YSEFYDITEAWARVVVENQFIEKNGKWHIDFEDFEKKAKECKIFLLCNPHNPLGIVWEPE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHCEEEEEECCCCCEEEEECHH
ELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEISKKIITCVSATKTFNLAG
HHHHHHHHHHHCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEC
LQASTTIFPNEQMKQKFDGFWMNMDIQRNNAFSSVAMEAAYNEGEEWLTQLLAYVSENFD
CCCCCEECCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
FIKKYFDENIPKIKPNVPDATYLVWLDCRELGMSNEELRDFMIHKVGLGLNEGCSFGRSL
HHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
SGYMRLNAACPRSVLEQALKQLKEAIDKL
CHHEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYDFDEIIDRSNNRAAKYDERVKKFGTSEVIPLWIADMDFRTAQPIIDACKRKAEEGVW
CCCCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
GYTSRPDSYFKAVQEWEKRRNQWDVDVSLMSWSLGVVPALSAIVKIFSHTGDKILIQTPV
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
YSEFYDITEAWARVVVENQFIEKNGKWHIDFEDFEKKAKECKIFLLCNPHNPLGIVWEPE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHCEEEEEECCCCCEEEEECHH
ELKRMAEICIANDVLLVSDEIHSDLIFHGKKHTPTATLSKEISKKIITCVSATKTFNLAG
HHHHHHHHHHHCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEC
LQASTTIFPNEQMKQKFDGFWMNMDIQRNNAFSSVAMEAAYNEGEEWLTQLLAYVSENFD
CCCCCEECCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
FIKKYFDENIPKIKPNVPDATYLVWLDCRELGMSNEELRDFMIHKVGLGLNEGCSFGRSL
HHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
SGYMRLNAACPRSVLEQALKQLKEAIDKL
CHHEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]