Click here to switch to the map view.

The map label for this gene is dnaX [H]

Identifier: 226947244

GI number: 226947244

Start: 32509

End: 34134

Strand: Direct

Name: dnaX [H]

Synonym: CLM_0037

Alternate gene names: 226947244

Gene position: 32509-34134 (Clockwise)

Preceding gene: 226947243

Following gene: 226947245

Centisome position: 0.78

GC content: 27.92

Gene sequence:

>1626_bases
GTGGGTTATACCGCATTATATAGAGAGTGGAGACCAAGAACATTTAAAGAGGTAGTTGGACAAAAACATATAACAGTGAC
ACTTAAAAATCAAGTTATAGAAAAAAGAATAGCTCATGCTTATCTTTTTTGTGGAACAAGAGGTACAGGTAAGACATCTA
CAGCAAAAATACTATCAAAAGCAGTAAATTGTTTAAATCCTAAGGATGGTGAACCTTGTAACGAATGTGAAATTTGTAAT
AAAATAAATAGTGGAACTTTAATGGATGTAATAGAAATGGATGCTGCTTCTAAAAGGAAATTAGAGGACATAAAGGAAGT
TATAGAAAATGTAAAATATCCACCACAGGAAGGGAAAAATAAGGTTTATATAATGGATGAGGTTCATATGTTAACTCAAG
AAGCAGTAAATGCTTTTTTGAAAACTTTAGAAGAACCTCCGAGCAATGTAATATTCATATTAGCAACTACAGATCCTCAA
AAATTACCTATAACTATATTATCTAGATGTCAACGATTTGATTTTAGAAGAATAAGAAATGAGGAAATATTTGAAAGGCT
TAGAGCAATAGTGTCAGAACAGGGCATATATGCAGATGATAAAAGTCTTAATCTTATAGCTAGAATGTCAGATGGGGCCA
TGAGAGATGCTCTTAGTATATTAGATCAAGTTATATCTACTGGAGATGGGAAGGTAGAGTATGATCAAGTCTTAGATATG
CTAGGATTAGTTACTAATGAAAATCTTCTAAGAATTACAAACAGTATAATAGAAAAAGATGTAGAGAAATCTATGAGGAT
AATAGAAGATATAGTGCTAAGTGGAAAAGACATATATAATTTTATAAAAGATATGATAACTCATCTTAGAAATATACTTA
TGGTTAAAGTAAGCAAAAATCCAAATGAAATATTAGATATGTCCAGTGAAAATATTGATTTAGTAAAAGAGCAGTCTGAA
AAAATAAGAATAGAAGAAATAATGAGGAATATAAAAATACTTCAAGAAGCAGAACAACAATCTAAATGGGTAAAGCAAAA
CAGAATATATTTAGAATTGGCTGTACTTAAAATGTGTAAAATAGAATATGATACATCTAAAGAAGTTATACTTTCTAGGC
TTAATAAAATAGAAGAGCTTATAAAATCAGGTAATATAAAATTAGCAATAAATGAAGAAAAGAAAAAAATAGAGCCAAAG
GAATTTAATCTAAAAAGAGAAAAAGAAAGTATGCAACATAGTAAAATAGAAAAAAATTCATTAGAAGATTATAATAAGGA
CTCTAAATTAACTGTAGAAACTGTCAAAAAAATGTGGCACGATATATTAGAAGCTTTTAAAGCAAGAAGACTTATGGTAT
TATATGCAGCTTTAGTTACTGCAAACATAACAGATTGCAAAGAAGGCATTATTACTTTAAATTATAATAAGCAGTATTCT
TTTAATAAAAAGAGATTAGAAAAGCCAGAAAATAATAAAGTAGTTCAGGAAATTTTTTCTGAGGTACTAAAAGAGAAAAT
TAGAATAATATATATTGTAGAGGAAAATGCTAAAGAAGAAAATTTACCAGAAGAGATTTTAAAAAATACTTTTGGAGAGA
ATATACTAGAAATAATTGATGAATAG

Upstream 100 bases:

>100_bases
TTAAAGGTACTATTAAAGGTACCTTTTATTTTTTATAATAAAATATTAGTGTATAATATTATATATAGCTTCAATTATTT
ATGGTAAGAAGGTGGTAACA

Downstream 100 bases:

>100_bases
CTAGTTAAATATTACAATTATGATATAATAAAAATCTAATTATTTATATTAAGGAGGAATTTTTATGGCAAGAGGTGGAT
TCCCTAACATGGGTGGAGCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MGYTALYREWRPRTFKEVVGQKHITVTLKNQVIEKRIAHAYLFCGTRGTGKTSTAKILSKAVNCLNPKDGEPCNECEICN
KINSGTLMDVIEMDAASKRKLEDIKEVIENVKYPPQEGKNKVYIMDEVHMLTQEAVNAFLKTLEEPPSNVIFILATTDPQ
KLPITILSRCQRFDFRRIRNEEIFERLRAIVSEQGIYADDKSLNLIARMSDGAMRDALSILDQVISTGDGKVEYDQVLDM
LGLVTNENLLRITNSIIEKDVEKSMRIIEDIVLSGKDIYNFIKDMITHLRNILMVKVSKNPNEILDMSSENIDLVKEQSE
KIRIEEIMRNIKILQEAEQQSKWVKQNRIYLELAVLKMCKIEYDTSKEVILSRLNKIEELIKSGNIKLAINEEKKKIEPK
EFNLKREKESMQHSKIEKNSLEDYNKDSKLTVETVKKMWHDILEAFKARRLMVLYAALVTANITDCKEGIITLNYNKQYS
FNKKRLEKPENNKVVQEIFSEVLKEKIRIIYIVEENAKEENLPEEILKNTFGENILEIIDE

Sequences:

>Translated_541_residues
MGYTALYREWRPRTFKEVVGQKHITVTLKNQVIEKRIAHAYLFCGTRGTGKTSTAKILSKAVNCLNPKDGEPCNECEICN
KINSGTLMDVIEMDAASKRKLEDIKEVIENVKYPPQEGKNKVYIMDEVHMLTQEAVNAFLKTLEEPPSNVIFILATTDPQ
KLPITILSRCQRFDFRRIRNEEIFERLRAIVSEQGIYADDKSLNLIARMSDGAMRDALSILDQVISTGDGKVEYDQVLDM
LGLVTNENLLRITNSIIEKDVEKSMRIIEDIVLSGKDIYNFIKDMITHLRNILMVKVSKNPNEILDMSSENIDLVKEQSE
KIRIEEIMRNIKILQEAEQQSKWVKQNRIYLELAVLKMCKIEYDTSKEVILSRLNKIEELIKSGNIKLAINEEKKKIEPK
EFNLKREKESMQHSKIEKNSLEDYNKDSKLTVETVKKMWHDILEAFKARRLMVLYAALVTANITDCKEGIITLNYNKQYS
FNKKRLEKPENNKVVQEIFSEVLKEKIRIIYIVEENAKEENLPEEILKNTFGENILEIIDE
>Mature_540_residues
GYTALYREWRPRTFKEVVGQKHITVTLKNQVIEKRIAHAYLFCGTRGTGKTSTAKILSKAVNCLNPKDGEPCNECEICNK
INSGTLMDVIEMDAASKRKLEDIKEVIENVKYPPQEGKNKVYIMDEVHMLTQEAVNAFLKTLEEPPSNVIFILATTDPQK
LPITILSRCQRFDFRRIRNEEIFERLRAIVSEQGIYADDKSLNLIARMSDGAMRDALSILDQVISTGDGKVEYDQVLDML
GLVTNENLLRITNSIIEKDVEKSMRIIEDIVLSGKDIYNFIKDMITHLRNILMVKVSKNPNEILDMSSENIDLVKEQSEK
IRIEEIMRNIKILQEAEQQSKWVKQNRIYLELAVLKMCKIEYDTSKEVILSRLNKIEELIKSGNIKLAINEEKKKIEPKE
FNLKREKESMQHSKIEKNSLEDYNKDSKLTVETVKKMWHDILEAFKARRLMVLYAALVTANITDCKEGIITLNYNKQYSF
NKKRLEKPENNKVVQEIFSEVLKEKIRIIYIVEENAKEENLPEEILKNTFGENILEIIDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=280, Percent_Identity=26.4285714285714, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI194306571, Length=280, Percent_Identity=26.4285714285714, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI194306567, Length=280, Percent_Identity=26.4285714285714, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI4506491, Length=277, Percent_Identity=23.826714801444, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI31881687, Length=277, Percent_Identity=23.826714801444, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1786676, Length=298, Percent_Identity=44.9664429530201, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1787119, Length=223, Percent_Identity=25.1121076233184, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787341, Length=140, Percent_Identity=34.2857142857143, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=294, Percent_Identity=25.1700680272109, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=311, Percent_Identity=23.1511254019293, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=258, Percent_Identity=27.1317829457364, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=290, Percent_Identity=24.8275862068966, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=265, Percent_Identity=22.6415094339623, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=306, Percent_Identity=22.8758169934641, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62733; Mature: 62601

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYTALYREWRPRTFKEVVGQKHITVTLKNQVIEKRIAHAYLFCGTRGTGKTSTAKILSK
CCCHHHHHHCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHH
AVNCLNPKDGEPCNECEICNKINSGTLMDVIEMDAASKRKLEDIKEVIENVKYPPQEGKN
HHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
KVYIMDEVHMLTQEAVNAFLKTLEEPPSNVIFILATTDPQKLPITILSRCQRFDFRRIRN
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EEIFERLRAIVSEQGIYADDKSLNLIARMSDGAMRDALSILDQVISTGDGKVEYDQVLDM
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
LGLVTNENLLRITNSIIEKDVEKSMRIIEDIVLSGKDIYNFIKDMITHLRNILMVKVSKN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCC
PNEILDMSSENIDLVKEQSEKIRIEEIMRNIKILQEAEQQSKWVKQNRIYLELAVLKMCK
CHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEYDTSKEVILSRLNKIEELIKSGNIKLAINEEKKKIEPKEFNLKREKESMQHSKIEKNS
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCHHCCCHHHHHHHHHHHHHHHH
LEDYNKDSKLTVETVKKMWHDILEAFKARRLMVLYAALVTANITDCKEGIITLNYNKQYS
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCC
FNKKRLEKPENNKVVQEIFSEVLKEKIRIIYIVEENAKEENLPEEILKNTFGENILEIID
CCHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
E
C
>Mature Secondary Structure 
GYTALYREWRPRTFKEVVGQKHITVTLKNQVIEKRIAHAYLFCGTRGTGKTSTAKILSK
CCHHHHHHCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHH
AVNCLNPKDGEPCNECEICNKINSGTLMDVIEMDAASKRKLEDIKEVIENVKYPPQEGKN
HHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
KVYIMDEVHMLTQEAVNAFLKTLEEPPSNVIFILATTDPQKLPITILSRCQRFDFRRIRN
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EEIFERLRAIVSEQGIYADDKSLNLIARMSDGAMRDALSILDQVISTGDGKVEYDQVLDM
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
LGLVTNENLLRITNSIIEKDVEKSMRIIEDIVLSGKDIYNFIKDMITHLRNILMVKVSKN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCC
PNEILDMSSENIDLVKEQSEKIRIEEIMRNIKILQEAEQQSKWVKQNRIYLELAVLKMCK
CHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEYDTSKEVILSRLNKIEELIKSGNIKLAINEEKKKIEPKEFNLKREKESMQHSKIEKNS
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCHHCCCHHHHHHHHHHHHHHHH
LEDYNKDSKLTVETVKKMWHDILEAFKARRLMVLYAALVTANITDCKEGIITLNYNKQYS
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCC
FNKKRLEKPENNKVVQEIFSEVLKEKIRIIYIVEENAKEENLPEEILKNTFGENILEIID
CCHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]