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The map label for this gene is ptpB [H]

Identifier: 226225088

GI number: 226225088

Start: 2589575

End: 2589982

Strand: Reverse

Name: ptpB [H]

Synonym: Lm4b_02509b

Alternate gene names: 226225088

Gene position: 2589982-2589575 (Counterclockwise)

Preceding gene: 226225089

Following gene: 226225087

Centisome position: 88.92

GC content: 39.95

Gene sequence:

>408_bases
ATGAAGGTATTATTTGTTTGTACAGGAAATACGTGCCGAAGCCCTTTAGCTGAAAAAATCTTGCAGAACTTGCGTCCGGA
TTTAGATGTTTGTTCAGCTGGGACACGTGCTCTGGACGGGGACGCCATCTCTGAAAACTCACGTCAAATTCTCGCGCAGA
TGAATTTGCCTACAACGCACCAAGCTAAAAAAATCACAGAAGCAGATATAGATTGGGCAGACCAAATCTACGTAATGACT
CAAAATCATCAAGCGGAACTAAAAAGCCTTTTTCCAAAAGCGAGCGATAAAATTCAACTAATTTCCGAAGATAAAACAGA
TATTCCAGATCCTTACGGTGGATCAATCGAGCAATACGAAATCACCTATTACGAACTAAAAAGTGCAATTTCCGAACGTT
TTTTATAA

Upstream 100 bases:

>100_bases
ATGTAGATGTGATTTTTGCGGAAGTGTATCCAGAAACGGAACTTGGAGCAGCGATTATGAACCGATTAGAAAAAGCTGCT
GGCAACAGGAGGATTCGCGA

Downstream 100 bases:

>100_bases
GTGAAGCGCTTCACTATCGGAAATTGCGTTTTTTTATTCCAAAATGCTTGCTTTTCTACCCGATTTAAGTAATTATTAAA
GATAATACATAACAGTTCAC

Product: phosphatase

Products: NA

Alternate protein names: Phosphotyrosine phosphatase B; PTPase B [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MKVLFVCTGNTCRSPLAEKILQNLRPDLDVCSAGTRALDGDAISENSRQILAQMNLPTTHQAKKITEADIDWADQIYVMT
QNHQAELKSLFPKASDKIQLISEDKTDIPDPYGGSIEQYEITYYELKSAISERFL

Sequences:

>Translated_135_residues
MKVLFVCTGNTCRSPLAEKILQNLRPDLDVCSAGTRALDGDAISENSRQILAQMNLPTTHQAKKITEADIDWADQIYVMT
QNHQAELKSLFPKASDKIQLISEDKTDIPDPYGGSIEQYEITYYELKSAISERFL
>Mature_135_residues
MKVLFVCTGNTCRSPLAEKILQNLRPDLDVCSAGTRALDGDAISENSRQILAQMNLPTTHQAKKITEADIDWADQIYVMT
QNHQAELKSLFPKASDKIQLISEDKTDIPDPYGGSIEQYEITYYELKSAISERFL

Specific function: Dephosphorylates the phosphotyrosine-containing proteins [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788375, Length=124, Percent_Identity=34.6774193548387, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI87081812, Length=133, Percent_Identity=30.8270676691729, Blast_Score=67, Evalue=6e-13,
Organism=Drosophila melanogaster, GI78711846, Length=128, Percent_Identity=40.625, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 15181; Mature: 15181

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLFVCTGNTCRSPLAEKILQNLRPDLDVCSAGTRALDGDAISENSRQILAQMNLPTTH
CEEEEEECCCCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCH
QAKKITEADIDWADQIYVMTQNHQAELKSLFPKASDKIQLISEDKTDIPDPYGGSIEQYE
HHHHCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCEEE
ITYYELKSAISERFL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVLFVCTGNTCRSPLAEKILQNLRPDLDVCSAGTRALDGDAISENSRQILAQMNLPTTH
CEEEEEECCCCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCH
QAKKITEADIDWADQIYVMTQNHQAELKSLFPKASDKIQLISEDKTDIPDPYGGSIEQYE
HHHHCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCEEE
ITYYELKSAISERFL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA