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The map label for this gene is ywlC [H]

Identifier: 226225089

GI number: 226225089

Start: 2589979

End: 2591016

Strand: Reverse

Name: ywlC [H]

Synonym: Lm4b_02510

Alternate gene names: 226225089

Gene position: 2591016-2589979 (Counterclockwise)

Preceding gene: 226225090

Following gene: 226225088

Centisome position: 88.96

GC content: 42.97

Gene sequence:

>1038_bases
ATGCAAACCATTCATTGGAACATAAATAACCAACAATCAAACCAAGTAATCTTTCAGGAAGCAGCCAAATTACTCCGAAG
CGGTGAATGCGTGGCTTTTCCAACTGAAACAGTGTACGGTCTTGGTGCAGACGCAACTAACCAAGCTGCTGTTCAAAAAA
TATATGAAGCGAAAGGCCGTCCGTCAGATAACCCATTAATTGTCCACATCGCCCGTCGTGAACAAATGGATCCTTTTGTT
GCAAGTTATCCAGTAAAAGCCATCCAGCTCATGGAAAAATTTTGGCCGGGTCCGCTAACGGTTATTCTTCCATTGAAAAA
AGATAGTTTGGCAACTAATGTTTCTGCGGGTTTATCCACAGTTGGCGTCCGTATGCCGGAACACCCTGTTAGTCTAGCAT
TGATAGATGCAGCGAATATTCCTGTTGCGGCTCCAAGCGCGAATCGTTCAGGAAAACCAAGTCCGACGACGGCGAGTCAT
GTAATAGAAGATTTAGATGGAAAAATAGCCGGAATTATCGATGGCGGCGCAACTGGTGTAGGTTTAGAATCCACCGTTAT
TGATTGTTCTTTAGATATCCCAGTTATTCTGCGCCCAGGCGGTGTTACAAAAGAACAGATTGAACAAATAATTGGCCCTG
TTGATATAGCGACAAACAACACGAAAGAAACGGAAAAACCAAAAGCACCTGGCATGAAATACACGCACTATGCCCCGAAA
GCGCCAGTTTATCTAATAGAAGGATCTATCCAATTTTGGCAAAGTGAAATAAATAAAGCGGAAGCTGCGAATAAAAAACT
CGGTATTTTGGCGACAAAAGAACTGATAAATCAACTAAACACGAGCGGTACCATCGAAATAACTGGCAGTATAAATGCAT
TGGACGAAATTGCTACAAGTCTTTACAAAGGTTTACGGGCTTTCGACCATGCTGATGTAGATGTGATTTTTGCGGAAGTG
TATCCAGAAACGGAACTTGGAGCAGCGATTATGAACCGATTAGAAAAAGCTGCTGGCAACAGGAGGATTCGCGAATGA

Upstream 100 bases:

>100_bases
TTCAAAAATAGCGATTTACAGGTTTTAAAAAACAATACTGTAAAAATAAGGCGGAAAACGTTAAAATATAATAGAAGTTA
TGTAAAGGGGACCGGAATTC

Downstream 100 bases:

>100_bases
AGGTATTATTTGTTTGTACAGGAAATACGTGCCGAAGCCCTTTAGCTGAAAAAATCTTGCAGAACTTGCGTCCGGATTTA
GATGTTTGTTCAGCTGGGAC

Product: yeast translation initiation protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQTIHWNINNQQSNQVIFQEAAKLLRSGECVAFPTETVYGLGADATNQAAVQKIYEAKGRPSDNPLIVHIARREQMDPFV
ASYPVKAIQLMEKFWPGPLTVILPLKKDSLATNVSAGLSTVGVRMPEHPVSLALIDAANIPVAAPSANRSGKPSPTTASH
VIEDLDGKIAGIIDGGATGVGLESTVIDCSLDIPVILRPGGVTKEQIEQIIGPVDIATNNTKETEKPKAPGMKYTHYAPK
APVYLIEGSIQFWQSEINKAEAANKKLGILATKELINQLNTSGTIEITGSINALDEIATSLYKGLRAFDHADVDVIFAEV
YPETELGAAIMNRLEKAAGNRRIRE

Sequences:

>Translated_345_residues
MQTIHWNINNQQSNQVIFQEAAKLLRSGECVAFPTETVYGLGADATNQAAVQKIYEAKGRPSDNPLIVHIARREQMDPFV
ASYPVKAIQLMEKFWPGPLTVILPLKKDSLATNVSAGLSTVGVRMPEHPVSLALIDAANIPVAAPSANRSGKPSPTTASH
VIEDLDGKIAGIIDGGATGVGLESTVIDCSLDIPVILRPGGVTKEQIEQIIGPVDIATNNTKETEKPKAPGMKYTHYAPK
APVYLIEGSIQFWQSEINKAEAANKKLGILATKELINQLNTSGTIEITGSINALDEIATSLYKGLRAFDHADVDVIFAEV
YPETELGAAIMNRLEKAAGNRRIRE
>Mature_345_residues
MQTIHWNINNQQSNQVIFQEAAKLLRSGECVAFPTETVYGLGADATNQAAVQKIYEAKGRPSDNPLIVHIARREQMDPFV
ASYPVKAIQLMEKFWPGPLTVILPLKKDSLATNVSAGLSTVGVRMPEHPVSLALIDAANIPVAAPSANRSGKPSPTTASH
VIEDLDGKIAGIIDGGATGVGLESTVIDCSLDIPVILRPGGVTKEQIEQIIGPVDIATNNTKETEKPKAPGMKYTHYAPK
APVYLIEGSIQFWQSEINKAEAANKKLGILATKELINQLNTSGTIEITGSINALDEIATSLYKGLRAFDHADVDVIFAEV
YPETELGAAIMNRLEKAAGNRRIRE

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=186, Percent_Identity=32.7956989247312, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI2367210, Length=155, Percent_Identity=32.258064516129, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87081864, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=373, Percent_Identity=40.4825737265416, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI78707274, Length=180, Percent_Identity=30.5555555555556, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 37138; Mature: 37138

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIHWNINNQQSNQVIFQEAAKLLRSGECVAFPTETVYGLGADATNQAAVQKIYEAKGR
CCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCHHHEECCCCCCHHHHHHHHHHHCCC
PSDNPLIVHIARREQMDPFVASYPVKAIQLMEKFWPGPLTVILPLKKDSLATNVSAGLST
CCCCCEEEEEECCCCCCCHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCHHH
VGVRMPEHPVSLALIDAANIPVAAPSANRSGKPSPTTASHVIEDLDGKIAGIIDGGATGV
HCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCC
GLESTVIDCSLDIPVILRPGGVTKEQIEQIIGPVDIATNNTKETEKPKAPGMKYTHYAPK
CCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEECCCCC
APVYLIEGSIQFWQSEINKAEAANKKLGILATKELINQLNTSGTIEITGSINALDEIATS
CCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
LYKGLRAFDHADVDVIFAEVYPETELGAAIMNRLEKAAGNRRIRE
HHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTIHWNINNQQSNQVIFQEAAKLLRSGECVAFPTETVYGLGADATNQAAVQKIYEAKGR
CCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCHHHEECCCCCCHHHHHHHHHHHCCC
PSDNPLIVHIARREQMDPFVASYPVKAIQLMEKFWPGPLTVILPLKKDSLATNVSAGLST
CCCCCEEEEEECCCCCCCHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCHHH
VGVRMPEHPVSLALIDAANIPVAAPSANRSGKPSPTTASHVIEDLDGKIAGIIDGGATGV
HCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCC
GLESTVIDCSLDIPVILRPGGVTKEQIEQIIGPVDIATNNTKETEKPKAPGMKYTHYAPK
CCCCEEEEEECCCCEEEECCCCCHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEECCCCC
APVYLIEGSIQFWQSEINKAEAANKKLGILATKELINQLNTSGTIEITGSINALDEIATS
CCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
LYKGLRAFDHADVDVIFAEVYPETELGAAIMNRLEKAAGNRRIRE
HHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]