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The map label for this gene is pgcA [H]

Identifier: 226225023

GI number: 226225023

Start: 2522199

End: 2523929

Strand: Reverse

Name: pgcA [H]

Synonym: Lm4b_02444

Alternate gene names: 226225023

Gene position: 2523929-2522199 (Counterclockwise)

Preceding gene: 226225024

Following gene: 226225022

Centisome position: 86.65

GC content: 39.86

Gene sequence:

>1731_bases
ATGAATTGGCAAGAAGAATATCAAAAATGGGTTGCTAATGACAAATTAGATAGCACATTAAGAAAACAATTAACGAATAT
GGAAGCAAATGAAAAAGAACTTGAGGATAGTTTTTATCGTAATATGGAATTTGGAACGGCTGGGATGCGTGGTGTACTAG
GCGCTGGAACAAACCGCATGAATATCTATACTATTCGTAAGGCTTCTCTAGGTTTGGCGCAATTTGTGGCGGAGAACGGT
GACGAGGCTAAGAAGCGCGGAATAGTAATTGCGTATGACCCTCGTCATATGTCACGCGAATTTGCTTTTGAATCGGCGGC
GGTATTAGGGCATCATGGTGTGAAAAGCTATGTTTTTGATGCGCTTCGACCAACACCGGAACTTTCCTTTGCAGTACGTC
ATTTAAATGCGTTTGGTGGGATTGTTATTACAGCTAGCCATAACCCACCAGAATACAATGGCTACAAGATTTATGGTGAA
GATGGCGGACAAATGCCTCCAACAGGGGCAAGTGCTGTAATTGAATACATAAACGCGGTAGAGGATATTTTTTCTGTAGA
AGTAGCGAACCAAGAGCTATTAATTGAAAATGGTTTACTTGAGGTAATCAGTGAAAAAGTAGACCGTCCATATTTGGAAA
AATTAAAAGAGGTTATTGTCAATAAAGAGCTTGTTCAAGAACGAGGGGAGGATTTGAAAATTGTTTTCACGCCCCTTCAT
GGTACTGGCGGAATTCTTGGCGTTCCTGCGCTTGAAAGTGTTGGCTTTACGAATATTGTTAAGGTTGACGAGCAATTTGT
GAATGATCCCGATTTTGGAACGGTAAAATCGCCTAACCCGGAAAACCGCGAAGCCTTTTTACTTGCGATTGAATATGGTA
AGAAGTTTGGTGGCGACATTTTAGTCGGAACAGATCCGGATGCTGACCGTTTAGGTGTGGCAGTTCGTAATCTTGACGGC
GAATATGAAGTGTTATCTGGAAACCAGATTGGCGCGATTATTTTACATTATTTATTAAAACAAAAGAAAGCGCAAAATGA
ATTGCCAGCTAATGCAGCGGTATTAAAATCTATTGTAACAAGTAATCTTGGAACAGAAATCGCGAAACATTACGGTGCGG
AAATGATTGAAGTATTAACTGGTTTCAAATTTATTGCAGAACAAATTAAGCACTTTGAAGAAACTGGCAAGCATACGTTT
GAATTTGGTTATGAAGAAAGTAATGGTTATATGGTTAAGCCGTTTACGCGTGATAAAGATGCGATTCAAGCGGTGCTTGC
GATTGCGGAAGTGGCGCTCGTTAGCAAAGTAGAAGGTGGAAGTTTACTAGAAGATTTAGAGCAAATTTATGCTGAGTTTG
GCTATTACAAAGAAGATCTAGTTTCCTTAACTTTAAGCGGTAAGGATGGTTCTCGGCGCATCAAAGAAATTACAAGTAAT
TTTCGCGAGCAACTACCAACAAGTATGGGTGGATTCCCCGTGGAACGTGCGGAAGATTATTTAAGAAGCGAAACAACTTG
GATTGCTACCGGAAAAACGGAAGCGATTCATTTGCCAACAGCAGATGTCATTAAATGTTATTTTGAAGATGGTTCATGGT
TCTGTTTACGTCCATCCGGCACAGAACCGAAAATCAAATTCTACTTTAGTATTCGTGGTGAAAGTAAAGAAGAAAGTGCA
ACAAAATTAGAAAAAGTGAAAGCTGATTTGATGCAACATATCGAAGCTTAA

Upstream 100 bases:

>100_bases
TTCGACCAGAAAAACCTTTTACATCTAGAACAGCTTTTCGTTTCACAGTGGAGAGCTGATAAATTTTAATTAAAGAGTTC
TAAATGAAGGAGTGTAGAGA

Downstream 100 bases:

>100_bases
AAAGAAAAATCCCGGAAACTCGCTTTAGAGACTTTTCCGGGATTTTCTAGTGAGAAGTGTGCTAAAATGGAAGATAGATA
TTATTTGTGCGAAAGGATGA

Product: phosphomannomutase and phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MNWQEEYQKWVANDKLDSTLRKQLTNMEANEKELEDSFYRNMEFGTAGMRGVLGAGTNRMNIYTIRKASLGLAQFVAENG
DEAKKRGIVIAYDPRHMSREFAFESAAVLGHHGVKSYVFDALRPTPELSFAVRHLNAFGGIVITASHNPPEYNGYKIYGE
DGGQMPPTGASAVIEYINAVEDIFSVEVANQELLIENGLLEVISEKVDRPYLEKLKEVIVNKELVQERGEDLKIVFTPLH
GTGGILGVPALESVGFTNIVKVDEQFVNDPDFGTVKSPNPENREAFLLAIEYGKKFGGDILVGTDPDADRLGVAVRNLDG
EYEVLSGNQIGAIILHYLLKQKKAQNELPANAAVLKSIVTSNLGTEIAKHYGAEMIEVLTGFKFIAEQIKHFEETGKHTF
EFGYEESNGYMVKPFTRDKDAIQAVLAIAEVALVSKVEGGSLLEDLEQIYAEFGYYKEDLVSLTLSGKDGSRRIKEITSN
FREQLPTSMGGFPVERAEDYLRSETTWIATGKTEAIHLPTADVIKCYFEDGSWFCLRPSGTEPKIKFYFSIRGESKEESA
TKLEKVKADLMQHIEA

Sequences:

>Translated_576_residues
MNWQEEYQKWVANDKLDSTLRKQLTNMEANEKELEDSFYRNMEFGTAGMRGVLGAGTNRMNIYTIRKASLGLAQFVAENG
DEAKKRGIVIAYDPRHMSREFAFESAAVLGHHGVKSYVFDALRPTPELSFAVRHLNAFGGIVITASHNPPEYNGYKIYGE
DGGQMPPTGASAVIEYINAVEDIFSVEVANQELLIENGLLEVISEKVDRPYLEKLKEVIVNKELVQERGEDLKIVFTPLH
GTGGILGVPALESVGFTNIVKVDEQFVNDPDFGTVKSPNPENREAFLLAIEYGKKFGGDILVGTDPDADRLGVAVRNLDG
EYEVLSGNQIGAIILHYLLKQKKAQNELPANAAVLKSIVTSNLGTEIAKHYGAEMIEVLTGFKFIAEQIKHFEETGKHTF
EFGYEESNGYMVKPFTRDKDAIQAVLAIAEVALVSKVEGGSLLEDLEQIYAEFGYYKEDLVSLTLSGKDGSRRIKEITSN
FREQLPTSMGGFPVERAEDYLRSETTWIATGKTEAIHLPTADVIKCYFEDGSWFCLRPSGTEPKIKFYFSIRGESKEESA
TKLEKVKADLMQHIEA
>Mature_576_residues
MNWQEEYQKWVANDKLDSTLRKQLTNMEANEKELEDSFYRNMEFGTAGMRGVLGAGTNRMNIYTIRKASLGLAQFVAENG
DEAKKRGIVIAYDPRHMSREFAFESAAVLGHHGVKSYVFDALRPTPELSFAVRHLNAFGGIVITASHNPPEYNGYKIYGE
DGGQMPPTGASAVIEYINAVEDIFSVEVANQELLIENGLLEVISEKVDRPYLEKLKEVIVNKELVQERGEDLKIVFTPLH
GTGGILGVPALESVGFTNIVKVDEQFVNDPDFGTVKSPNPENREAFLLAIEYGKKFGGDILVGTDPDADRLGVAVRNLDG
EYEVLSGNQIGAIILHYLLKQKKAQNELPANAAVLKSIVTSNLGTEIAKHYGAEMIEVLTGFKFIAEQIKHFEETGKHTF
EFGYEESNGYMVKPFTRDKDAIQAVLAIAEVALVSKVEGGSLLEDLEQIYAEFGYYKEDLVSLTLSGKDGSRRIKEITSN
FREQLPTSMGGFPVERAEDYLRSETTWIATGKTEAIHLPTADVIKCYFEDGSWFCLRPSGTEPKIKFYFSIRGESKEESA
TKLEKVKADLMQHIEA

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=589, Percent_Identity=32.597623089983, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI31377548, Length=573, Percent_Identity=31.413612565445, Blast_Score=252, Evalue=7e-67,
Organism=Escherichia coli, GI1786904, Length=567, Percent_Identity=25.5731922398589, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71993870, Length=553, Percent_Identity=31.1030741410488, Blast_Score=217, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71993878, Length=312, Percent_Identity=32.3717948717949, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323934, Length=605, Percent_Identity=30.9090909090909, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20129809, Length=593, Percent_Identity=30.6913996627319, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24651977, Length=460, Percent_Identity=31.7391304347826, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653722, Length=577, Percent_Identity=28.42287694974, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64120; Mature: 64120

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWQEEYQKWVANDKLDSTLRKQLTNMEANEKELEDSFYRNMEFGTAGMRGVLGAGTNRM
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCE
NIYTIRKASLGLAQFVAENGDEAKKRGIVIAYDPRHMSREFAFESAAVLGHHGVKSYVFD
EEEEEECHHHHHHHHHHCCCCHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHH
ALRPTPELSFAVRHLNAFGGIVITASHNPPEYNGYKIYGEDGGQMPPTGASAVIEYINAV
HHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
EDIFSVEVANQELLIENGLLEVISEKVDRPYLEKLKEVIVNKELVQERGEDLKIVFTPLH
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHCCCCEEEEEEECC
GTGGILGVPALESVGFTNIVKVDEQFVNDPDFGTVKSPNPENREAFLLAIEYGKKFGGDI
CCCCEECCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCE
LVGTDPDADRLGVAVRNLDGEYEVLSGNQIGAIILHYLLKQKKAQNELPANAAVLKSIVT
EECCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SNLGTEIAKHYGAEMIEVLTGFKFIAEQIKHFEETGKHTFEFGYEESNGYMVKPFTRDKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECEECCCCEEEECCCCCHH
AIQAVLAIAEVALVSKVEGGSLLEDLEQIYAEFGYYKEDLVSLTLSGKDGSRRIKEITSN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHH
FREQLPTSMGGFPVERAEDYLRSETTWIATGKTEAIHLPTADVIKCYFEDGSWFCLRPSG
HHHHCCHHCCCCCHHHHHHHHHCCCEEEECCCCCEEECCCHHHEEEEEECCCEEEECCCC
TEPKIKFYFSIRGESKEESATKLEKVKADLMQHIEA
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNWQEEYQKWVANDKLDSTLRKQLTNMEANEKELEDSFYRNMEFGTAGMRGVLGAGTNRM
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCE
NIYTIRKASLGLAQFVAENGDEAKKRGIVIAYDPRHMSREFAFESAAVLGHHGVKSYVFD
EEEEEECHHHHHHHHHHCCCCHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHH
ALRPTPELSFAVRHLNAFGGIVITASHNPPEYNGYKIYGEDGGQMPPTGASAVIEYINAV
HHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
EDIFSVEVANQELLIENGLLEVISEKVDRPYLEKLKEVIVNKELVQERGEDLKIVFTPLH
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHCCCCEEEEEEECC
GTGGILGVPALESVGFTNIVKVDEQFVNDPDFGTVKSPNPENREAFLLAIEYGKKFGGDI
CCCCEECCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCE
LVGTDPDADRLGVAVRNLDGEYEVLSGNQIGAIILHYLLKQKKAQNELPANAAVLKSIVT
EECCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SNLGTEIAKHYGAEMIEVLTGFKFIAEQIKHFEETGKHTFEFGYEESNGYMVKPFTRDKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECEECCCCEEEECCCCCHH
AIQAVLAIAEVALVSKVEGGSLLEDLEQIYAEFGYYKEDLVSLTLSGKDGSRRIKEITSN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHH
FREQLPTSMGGFPVERAEDYLRSETTWIATGKTEAIHLPTADVIKCYFEDGSWFCLRPSG
HHHHCCHHCCCCCHHHHHHHHHCCCEEEECCCCCEEECCCHHHEEEEEECCCEEEECCCC
TEPKIKFYFSIRGESKEESATKLEKVKADLMQHIEA
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]