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The map label for this gene is mro [H]

Identifier: 226225024

GI number: 226225024

Start: 2523971

End: 2525032

Strand: Reverse

Name: mro [H]

Synonym: Lm4b_02445

Alternate gene names: 226225024

Gene position: 2525032-2523971 (Counterclockwise)

Preceding gene: 226225025

Following gene: 226225023

Centisome position: 86.69

GC content: 39.74

Gene sequence:

>1062_bases
GTGATTTTTATCGAAGTAATGAAGGAGCGATTTGGGGAGTTTGAGGGAGAAACTGTTTGGAAGTGGACGATGGTAAATGA
TCATGGTATGCGCATGAGTGTTTTAAATTACGGAGCGATTGTTACTTCCCTTGAAACAAAAGATAAATTTGGTGATTTTG
CGAATATTAGTCTTGGTTTTACAAATTTAGATGATTATTTGGCACACTCCCCATACTTCGGCGCGACACTTGGCCCTGTT
GCTGGACGCATTACAAATGGGCAATTTAGTTTGGACGGTAAACAATTTCAACTGATTCAAAATGAAGGAGCTAACCATCG
TCACGGTGGGAAATTCAATTTTAGTAAGAAGCTTTGGGATGTTTCAGTAGAAAAAAGTCTTGATCAAATTGTGATGACTT
TTGAATACTGCTGGGCGGATGGAGAAAATGGCTATCCAGGAAATATTGATGCAAAAATGACATATACGTTAAATAATAAA
AATGAATGGCTGCTTGATTATGAAGCGAAAAGCGATCAGCCGACTATATATAACCCGAGCAATCATATTTATTTTAATCT
AAGCGGAGAAGCTGGTTCAACGGTTTTACAACATCAGCTTTGGGTTAATAGTGACAGCTTCCTACCAATTGATGAAGAGT
TTCTCCCAATTGGGGAAAAGCGGTTAGCGGAAAATACTATCTTTGATTTGCGTGCAGGTCGTGAAGTAGCGGAGATTACA
CAAAGTCAGGACCAGCAAGTAAAATTAGTTGGTGCGGGGCTGGATCATGCATTCATTTTAAAACATGAAAATAGTCGTCC
AGATGCAGTTTTGTTTGATCCAAAGTCAGGACGGCGCTTGGAAATGGAAACCAAAGCTGACTCGGTATTAATTTATACGG
CGAATAGTTTGGATGGCTCTTTTGAGATTGGCGAGCGAACTGTGCCAAAATATGCTGGCATAACAATGGAAACACAGGGT
TTAGTAGATGCGATTAACCATGACGGATTTGGTGATATTGTACTTCGACCAGAAAAACCTTTTACATCTAGAACAGCTTT
TCGTTTCACAGTGGAGAGCTGA

Upstream 100 bases:

>100_bases
GGTTGGGAGCCAACTTATACAGACGTAAAAGATATTATCGCCACTGCTTGGAAATGGCACGTATCTCATCCAAATGGCTA
TTAATAACTTATGAAGGAAT

Downstream 100 bases:

>100_bases
TAAATTTTAATTAAAGAGTTCTAAATGAAGGAGTGTAGAGAATGAATTGGCAAGAAGAATATCAAAAATGGGTTGCTAAT
GACAAATTAGATAGCACATT

Product: aldose 1-epimerase (mutarotase)

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MIFIEVMKERFGEFEGETVWKWTMVNDHGMRMSVLNYGAIVTSLETKDKFGDFANISLGFTNLDDYLAHSPYFGATLGPV
AGRITNGQFSLDGKQFQLIQNEGANHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGNIDAKMTYTLNNK
NEWLLDYEAKSDQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEIT
QSQDQQVKLVGAGLDHAFILKHENSRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIGERTVPKYAGITMETQG
LVDAINHDGFGDIVLRPEKPFTSRTAFRFTVES

Sequences:

>Translated_353_residues
MIFIEVMKERFGEFEGETVWKWTMVNDHGMRMSVLNYGAIVTSLETKDKFGDFANISLGFTNLDDYLAHSPYFGATLGPV
AGRITNGQFSLDGKQFQLIQNEGANHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGNIDAKMTYTLNNK
NEWLLDYEAKSDQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEIT
QSQDQQVKLVGAGLDHAFILKHENSRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIGERTVPKYAGITMETQG
LVDAINHDGFGDIVLRPEKPFTSRTAFRFTVES
>Mature_353_residues
MIFIEVMKERFGEFEGETVWKWTMVNDHGMRMSVLNYGAIVTSLETKDKFGDFANISLGFTNLDDYLAHSPYFGATLGPV
AGRITNGQFSLDGKQFQLIQNEGANHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGNIDAKMTYTLNNK
NEWLLDYEAKSDQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEIT
QSQDQQVKLVGAGLDHAFILKHENSRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIGERTVPKYAGITMETQG
LVDAINHDGFGDIVLRPEKPFTSRTAFRFTVES

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=350, Percent_Identity=37.4285714285714, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI1786971, Length=342, Percent_Identity=30.4093567251462, Blast_Score=166, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=29.1793313069909, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=29.1793313069909, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319493, Length=375, Percent_Identity=26.4, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322004, Length=363, Percent_Identity=29.2011019283747, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=313, Percent_Identity=28.7539936102236, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24659048, Length=350, Percent_Identity=32.5714285714286, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24668278, Length=345, Percent_Identity=31.0144927536232, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24583720, Length=351, Percent_Identity=31.3390313390313, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24668282, Length=346, Percent_Identity=30.3468208092486, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24641876, Length=355, Percent_Identity=25.0704225352113, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39803; Mature: 39803

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFIEVMKERFGEFEGETVWKWTMVNDHGMRMSVLNYGAIVTSLETKDKFGDFANISLGF
CEEHEEHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCEEEEEECCHHHCCCEEEEEEEC
TNLDDYLAHSPYFGATLGPVAGRITNGQFSLDGKQFQLIQNEGANHRHGGKFNFSKKLWD
CCCHHHHHCCCCCCCCCCCCCCEEECCEEEECCCEEEEEECCCCCCCCCCEECCCHHEEE
VSVEKSLDQIVMTFEYCWADGENGYPGNIDAKMTYTLNNKNEWLLDYEAKSDQPTIYNPS
EHHHHHHHHHHEEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEECCC
NHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEIT
CEEEEEECCCCCCEEEEEEEEECCCCCCCCCHHHCCCCHHHHHCCCEEEECCCCHHHHHH
QSQDQQVKLVGAGLDHAFILKHENSRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGS
CCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCEEEEECCCCEEEEEEECCCCCC
FEIGERTVPKYAGITMETQGLVDAINHDGFGDIVLRPEKPFTSRTAFRFTVES
EECCCCCCCHHCCEEEECCHHHHHHCCCCCCCEEEECCCCCCCCEEEEEEECC
>Mature Secondary Structure
MIFIEVMKERFGEFEGETVWKWTMVNDHGMRMSVLNYGAIVTSLETKDKFGDFANISLGF
CEEHEEHHHHHCCCCCCEEEEEEEECCCCCEEEEEECCEEEEEECCHHHCCCEEEEEEEC
TNLDDYLAHSPYFGATLGPVAGRITNGQFSLDGKQFQLIQNEGANHRHGGKFNFSKKLWD
CCCHHHHHCCCCCCCCCCCCCCEEECCEEEECCCEEEEEECCCCCCCCCCEECCCHHEEE
VSVEKSLDQIVMTFEYCWADGENGYPGNIDAKMTYTLNNKNEWLLDYEAKSDQPTIYNPS
EHHHHHHHHHHEEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEECCC
NHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEIT
CEEEEEECCCCCCEEEEEEEEECCCCCCCCCHHHCCCCHHHHHCCCEEEECCCCHHHHHH
QSQDQQVKLVGAGLDHAFILKHENSRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGS
CCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCEEEEECCCCEEEEEEECCCCCC
FEIGERTVPKYAGITMETQGLVDAINHDGFGDIVLRPEKPFTSRTAFRFTVES
EECCCCCCCHHCCEEEECCHHHHHHCCCCCCCEEEECCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]