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The map label for this gene is isdE [H]

Identifier: 226224978

GI number: 226224978

Start: 2471631

End: 2472602

Strand: Reverse

Name: isdE [H]

Synonym: Lm4b_02399

Alternate gene names: 226224978

Gene position: 2472602-2471631 (Counterclockwise)

Preceding gene: 226224981

Following gene: 226224977

Centisome position: 84.89

GC content: 40.95

Gene sequence:

>972_bases
ATGAAGAAAATAACTATATTGACGTTAAGTATAACAGCCGCACTACTCCTTGCATCGTGTGGAAATGATACGGCAACTGA
TACGAATAATGAAACAACTAAAACGGAAAGTAAATCGCAAGCGGCTCTAACGATAACAGATATGGCTGGGCGTGATGTTT
CTTTTGATAAAAAACCAGAACGGATTATCGCACTGACGAATGCGGATATGAATATTATCTATGCACTTGGTGGAACGGTG
GTAGGTCGCCAAACAACAGACGCGAGTGGTGTTCCAGATGGTGCGAAGAAAGCTACAGAAGTGGGCAATACCCATGATTT
GAATTTAGAAAAAATTGCCTCTCTTGGTGCTGATGCTATTGTCGCAAGTTCAGAACAAAACTTAAAAGATGTTCCTGCGA
TGGAAGGCGTCGGACCGAAAGTCGTGTTGACCGGAGCCAACTCAATTGACGAAATTAAAAAACAAACAGCCGTGCTTGGC
GAGCTTTTAGGCAAAGAGACAAAAGCCAAAGAGTTAGAAGCGAATATTGACCAAAAAGTGGCGGAAGTGAAGAAGAAGCA
ACAAGGTAAAAAAGTGCGCTCATTACTTGTTCTAGGGGCTCCTGGCAGTAATTACGCGGCGCTACCATCCTCATTAAGTG
GAAATGTTTTAGAAATTGCTGGTGGAGAAAATGTAGCGAAAGATTTTAAAGGCGTTGAAAACTTCCCACAATACGCTTCG
ATGAATGTAGAAAAGATTGTTGCTGCTGACCCGGAAGTGATTTTCTTAATGATTCACGGTGGGGACGAAAAAGAAACAGA
AGCAGCATTCAAGAAAGAAATGAAACAAAATGAAGCTTGGAATTCAACAAGCGCCGTTAAAAATGATCATATTGTCGTAC
TTCCTGCAGAGCTATTCGGAACAAATCCTGGAATTAAGATTGATCAAGCATTGGATTATATGACAGATGAGATAAATAAG
GTGGATAACTAA

Upstream 100 bases:

>100_bases
TTGAACATAGATGAAAATAATTCTCAATTAGGGGTTCGTCTTTTTGAATATCGTGTTATAATTTAGTAAAATGAAAAGGA
CAGTGTTGTGGAGGGGAATT

Downstream 100 bases:

>100_bases
TGACAACTGTGAAGGCGCATGATCCGCGGCGAAAACGTAGACGGATAACTTTTATTGTAGTAATCATTTTACTTATTTTA
GCTTTTTTCTACGGACTGAC

Product: ferrichrome ABC transporter fhuD precursor (ferrichrome-binding protein)

Products: NA

Alternate protein names: Iron-regulated surface determinant protein E; Staphylococcal iron-regulated protein F [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKKITILTLSITAALLLASCGNDTATDTNNETTKTESKSQAALTITDMAGRDVSFDKKPERIIALTNADMNIIYALGGTV
VGRQTTDASGVPDGAKKATEVGNTHDLNLEKIASLGADAIVASSEQNLKDVPAMEGVGPKVVLTGANSIDEIKKQTAVLG
ELLGKETKAKELEANIDQKVAEVKKKQQGKKVRSLLVLGAPGSNYAALPSSLSGNVLEIAGGENVAKDFKGVENFPQYAS
MNVEKIVAADPEVIFLMIHGGDEKETEAAFKKEMKQNEAWNSTSAVKNDHIVVLPAELFGTNPGIKIDQALDYMTDEINK
VDN

Sequences:

>Translated_323_residues
MKKITILTLSITAALLLASCGNDTATDTNNETTKTESKSQAALTITDMAGRDVSFDKKPERIIALTNADMNIIYALGGTV
VGRQTTDASGVPDGAKKATEVGNTHDLNLEKIASLGADAIVASSEQNLKDVPAMEGVGPKVVLTGANSIDEIKKQTAVLG
ELLGKETKAKELEANIDQKVAEVKKKQQGKKVRSLLVLGAPGSNYAALPSSLSGNVLEIAGGENVAKDFKGVENFPQYAS
MNVEKIVAADPEVIFLMIHGGDEKETEAAFKKEMKQNEAWNSTSAVKNDHIVVLPAELFGTNPGIKIDQALDYMTDEINK
VDN
>Mature_323_residues
MKKITILTLSITAALLLASCGNDTATDTNNETTKTESKSQAALTITDMAGRDVSFDKKPERIIALTNADMNIIYALGGTV
VGRQTTDASGVPDGAKKATEVGNTHDLNLEKIASLGADAIVASSEQNLKDVPAMEGVGPKVVLTGANSIDEIKKQTAVLG
ELLGKETKAKELEANIDQKVAEVKKKQQGKKVRSLLVLGAPGSNYAALPSSLSGNVLEIAGGENVAKDFKGVENFPQYAS
MNVEKIVAADPEVIFLMIHGGDEKETEAAFKKEMKQNEAWNSTSAVKNDHIVVLPAELFGTNPGIKIDQALDYMTDEINK
VDN

Specific function: Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors t

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786353, Length=206, Percent_Identity=28.6407766990291, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019957
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 34284; Mature: 34284

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITILTLSITAALLLASCGNDTATDTNNETTKTESKSQAALTITDMAGRDVSFDKKPE
CCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
RIIALTNADMNIIYALGGTVVGRQTTDASGVPDGAKKATEVGNTHDLNLEKIASLGADAI
EEEEEECCCCEEEEEECCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCE
VASSEQNLKDVPAMEGVGPKVVLTGANSIDEIKKQTAVLGELLGKETKAKELEANIDQKV
EECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AEVKKKQQGKKVRSLLVLGAPGSNYAALPSSLSGNVLEIAGGENVAKDFKGVENFPQYAS
HHHHHHHHHHHEEEEEEECCCCCCCEECCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHC
MNVEKIVAADPEVIFLMIHGGDEKETEAAFKKEMKQNEAWNSTSAVKNDHIVVLPAELFG
CCHHHHEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHC
TNPGIKIDQALDYMTDEINKVDN
CCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKITILTLSITAALLLASCGNDTATDTNNETTKTESKSQAALTITDMAGRDVSFDKKPE
CCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
RIIALTNADMNIIYALGGTVVGRQTTDASGVPDGAKKATEVGNTHDLNLEKIASLGADAI
EEEEEECCCCEEEEEECCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCCCE
VASSEQNLKDVPAMEGVGPKVVLTGANSIDEIKKQTAVLGELLGKETKAKELEANIDQKV
EECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AEVKKKQQGKKVRSLLVLGAPGSNYAALPSSLSGNVLEIAGGENVAKDFKGVENFPQYAS
HHHHHHHHHHHEEEEEEECCCCCCCEECCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHC
MNVEKIVAADPEVIFLMIHGGDEKETEAAFKKEMKQNEAWNSTSAVKNDHIVVLPAELFG
CCHHHHEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHC
TNPGIKIDQALDYMTDEINKVDN
CCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA