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The map label for this gene is argH

Identifier: 226224697

GI number: 226224697

Start: 2170166

End: 2171536

Strand: Direct

Name: argH

Synonym: Lm4b_02112

Alternate gene names: 226224697

Gene position: 2170166-2171536 (Clockwise)

Preceding gene: 226224696

Following gene: 226224698

Centisome position: 74.51

GC content: 40.92

Gene sequence:

>1371_bases
ATGGAAAAACTATGGGGCGGACGTTTTCAAGGGAAAAGTGAAGCATGGATTGACGATTTTGGTGCTTCGATTTCTTTTGA
TCAAAAAATGGCAAAAGAAGACTTGGCGGGAAGTTTAGCGCATGTCGCTATGCTCAGCAAATGCGGAATTATTCCTGCTT
CAGAAGCAGCTGAAATTACGGCCGGATTAAAAATCCTCCAAGAAAAATTAGCGCTTGGTGAGCTCGAATTCAGCACAGTT
AACGAAGATATTCATTTAAATATCGAAAAACTATTGCACGAGGAAATCGGCCCAGTCGCTGGAAAACTTCATACGGCGCG
CAGTCGGAATGATCAAGTTGCAACAGACATGCATTTGTATTTAAAACAAGCCGTAGCAGAAATTATTCAGTCATTAAAAC
ATTTACGCGTGGTGCTAGTCCAAAAAGCGGAGGCGAACGTCGAAACGATTATGCCTGGCTATACACACTTGCAACACGCC
CAACCCATCTCTTTTGCACATCATTTATTAGCTTACTTTGGAATGTTTACACGGGATTTGGAGCGTTTAGAAGAAAGTGT
CAAACGGATTGATATTTCACCGCTCGGTTCTGCTGCGCTGGCTGGGACGACTTTTCCGATTGACCGAGCCTACAGCGCTG
AATTACTTGGTTTTTCCGCTATCTATGAAAATAGTTTAGACGGCGTGAGTGATCGTGATTTTATTATTGAGTTTCTTAGT
AACAGTTCTATCTTAATGATGCATTTATCGCGTTTTTGTGAGGAACTGATACTTTGGACGAGTCATGAGTTTCAATTTGT
CGAGTTAACGGACGCTTTTTCAACGGGAAGTTCTATTATGCCGCAAAAGAAAAATCCAGATATGGCTGAGTTAATTCGCG
GTAAAACTGGCCGGGTTTACGGAAACCTGTTCGGCATGCTAACGGTTTTAAAAGGTCTCCCACTCGCTTACAATAAAGAC
TTGCAAGAAGATAAGGAAGGCATGTTTGATACGCTTGAGACGGTTCAAACAAGCTTAGATATTTTCGCAGGAATGATTGA
AACGATGAAGATCAACACAGAAATAATGGAAGAATCGACACAAAAAGATTTTTCCAATGCGACGGAACTAGCAGATTATT
TAGCGAAAAAAGGCGTTCCATTTAGAGAAGCGCATGAGATTGTTGGGAAATTGGTGCTTGAATGTACGCAAAATGGGATT
TATTTGCAAGATGTAGCGCTTAGCCACTATCAGGAAATAAATCCACTTATTGATGATGATATTTACGTGGTGCTTTCCTC
TAAAACTGCCGTGCAAAAAAGAAATTCTTACGGCGGGACTGGATTTGATCAAATTAAAGTTGCTCTCGAAAACGCGAAAA
AAACATTGTAA

Upstream 100 bases:

>100_bases
CCAAGATGCAGCAGTTGGTTTCATCAAGCTTTGGGGATTACCAACGAAAGTAAGCGCAGAAGTTAATTCAAAAGTGACAA
TAACAACTGAGGTGTAAAAA

Downstream 100 bases:

>100_bases
AACTAACTGGGATGCTGAATGGCGTTCCAGTTTTTTGCTGACTTCTCCCCCTTTTTCCTCTTACATGATTTGTCAGAGCA
CTACTTTTTTTGTTACTATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLSKCGIIPASEAAEITAGLKILQEKLALGELEFSTV
NEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLYLKQAVAEIIQSLKHLRVVLVQKAEANVETIMPGYTHLQHA
QPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKD
LQEDKEGMFDTLETVQTSLDIFAGMIETMKINTEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGI
YLQDVALSHYQEINPLIDDDIYVVLSSKTAVQKRNSYGGTGFDQIKVALENAKKTL

Sequences:

>Translated_456_residues
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLSKCGIIPASEAAEITAGLKILQEKLALGELEFSTV
NEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLYLKQAVAEIIQSLKHLRVVLVQKAEANVETIMPGYTHLQHA
QPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKD
LQEDKEGMFDTLETVQTSLDIFAGMIETMKINTEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGI
YLQDVALSHYQEINPLIDDDIYVVLSSKTAVQKRNSYGGTGFDQIKVALENAKKTL
>Mature_456_residues
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLSKCGIIPASEAAEITAGLKILQEKLALGELEFSTV
NEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLYLKQAVAEIIQSLKHLRVVLVQKAEANVETIMPGYTHLQHA
QPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKD
LQEDKEGMFDTLETVQTSLDIFAGMIETMKINTEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGI
YLQDVALSHYQEINPLIDDDIYVVLSSKTAVQKRNSYGGTGFDQIKVALENAKKTL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=44.4933920704846, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=44.4933920704846, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=41.6299559471366, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=41.6299559471366, Blast_Score=356, Evalue=2e-98,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=47.3568281938326, Blast_Score=434, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=44.5414847161572, Blast_Score=393, Evalue=1e-110,
Organism=Drosophila melanogaster, GI221473854, Length=454, Percent_Identity=40.7488986784141, Blast_Score=358, Evalue=5e-99,
Organism=Drosophila melanogaster, GI78706858, Length=454, Percent_Identity=40.7488986784141, Blast_Score=358, Evalue=5e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50779; Mature: 50779

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLSKCGIIPASEAAEIT
CCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AGLKILQEKLALGELEFSTVNEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLY
HHHHHHHHHHHHCCCCHHCCCCCCEECHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHH
LKQAVAEIIQSLKHLRVVLVQKAEANVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
ERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
HHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFGMLTVLKGLPLAYNKDLQEDKEGMFDTLETVQTSLDIFAGMIETMKINTEIMEEST
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGIYLQDVALSHYQEINPLIDDD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCC
IYVVLSSKTAVQKRNSYGGTGFDQIKVALENAKKTL
EEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLSKCGIIPASEAAEIT
CCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AGLKILQEKLALGELEFSTVNEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLY
HHHHHHHHHHHHCCCCHHCCCCCCEECHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHH
LKQAVAEIIQSLKHLRVVLVQKAEANVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
ERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
HHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFGMLTVLKGLPLAYNKDLQEDKEGMFDTLETVQTSLDIFAGMIETMKINTEIMEEST
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGIYLQDVALSHYQEINPLIDDD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCC
IYVVLSSKTAVQKRNSYGGTGFDQIKVALENAKKTL
EEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]