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The map label for this gene is obgE

Identifier: 226224138

GI number: 226224138

Start: 1555604

End: 1556893

Strand: Reverse

Name: obgE

Synonym: Lm4b_01547

Alternate gene names: 226224138

Gene position: 1556893-1555604 (Counterclockwise)

Preceding gene: 226224139

Following gene: 226224137

Centisome position: 53.45

GC content: 42.09

Gene sequence:

>1290_bases
ATGTTTGTAGATCAGGTTAAGATATATGTAAAAGCTGGTAATGGTGGGGACGGTATGGTAGCATTCCGTCGCGAAAAATT
TGTACCAAACGGTGGTCCTGCTGGCGGTGACGGTGGTAAAGGAGCAGACGTTGTATTTGTAGTAGATGAAGGTCTGCGTA
CATTGGTTGATTTCCGCTTTAAACGAATCTTTAAAGCAGAGCACGGCGAACATGGCATGAGTAAAAGTATGCATGGACGC
GGCGCAGAAGATTTAGTTGTCAAAGTACCACAAGGAACCATTGTAAAAGATATTGATACGGGTGAGATTATTGCTGATTT
AGTCGCACATGGTCAACGCGCAGTTATTGCAAAAGCTGGACGTGGCGGACGTGGTAACAAACGCTTTGCAACACCAGCAA
ATCCGGCTCCAGAACTTTCTGAAAACGGAGAACCTGGACAGGAACGAAATGTGCAATTAGAACTTAAAGTGTTAGCAGAT
GTTGGTTTAGTTGGTTTCCCAAGTGTCGGTAAATCAACCCTATTATCTGTTGTTTCTGCTGCGAGACCAAAAATCGCTGC
GTATCACTTTACGACGATTGTTCCAAACTTAGGAATGGTTGACGCAGGAGATGGTCGTAGCTTTGTTATGGCCGATTTAC
CGGGTCTAATTGAAGGCGCTAGTCAAGGTGTTGGTTTAGGGCATCAATTCTTACGTCATATCGAAAGAACACGTGTTATC
GTGCATGTCATTGATATGTCGGGCTCAGAAGGACGCGTTCCATACGAAGACTATATGGCTATCAATAATGAACTTGAACA
GTACAACTTGCGCCTAATGGAACGTCCACAAATTATTGTAGCTAATAAAATGGATATGCCAGATGCAGAAGAAAATTTAA
ACGAATTTAAAACAAAAATTGCTGAAGATATTCCGGTATTCCCAATTTCTGCGGTAACAAAAACGGGACTTCGCGAATTA
CTTCTTGCTATTGCGGATAAATTAGAAACAACTCCAGAATTTCCACTTAATGAAATTTTGGAACAAGAAGACGAAGATAC
AGTTCTTTACAAATATGTTGCTGAAGAACCTGACTTCGAGATCTCTAGAGAGCCAGACGGTACTTTTGTACTAAGTGGTG
CAAAAATTGAACGCTTATTCACGATGACAAACTTCGAGCGCGATGCATCTATTAGTCGTTTTGCTCGTCAGCTTCGTGCA
ATGGGTGTCGATGAGGCGCTTAGAAAACGTGGTGCTAAAGACGGCGATATCGTTCGCCTGCTTGATTATGAATTTGAATT
TATGGATTAA

Upstream 100 bases:

>100_bases
AATAAATATTTGGAAATAGAAATAAATATAGTGACAGATGTATAGTTTATTCGTTATAATGAAAGATAAGACTTTTAAGG
AACGGGAGAATATAAAAATT

Downstream 100 bases:

>100_bases
ATAAAGTGCTGCGCCAATTAGTTGGCGCACGCTTTTTTCCTAGCTACGATAAAAGGAGAGTTGAAAATGAAAATTGCTTA
TTTAGGCCCAGCAGCATCTT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRFKRIFKAEHGEHGMSKSMHGR
GAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAGRGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLAD
VGLVGFPSVGKSTLLSVVSAARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVI
VHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKIAEDIPVFPISAVTKTGLREL
LLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFEISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRA
MGVDEALRKRGAKDGDIVRLLDYEFEFMD

Sequences:

>Translated_429_residues
MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRFKRIFKAEHGEHGMSKSMHGR
GAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAGRGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLAD
VGLVGFPSVGKSTLLSVVSAARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVI
VHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKIAEDIPVFPISAVTKTGLREL
LLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFEISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRA
MGVDEALRKRGAKDGDIVRLLDYEFEFMD
>Mature_429_residues
MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRFKRIFKAEHGEHGMSKSMHGR
GAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAGRGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLAD
VGLVGFPSVGKSTLLSVVSAARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVI
VHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKIAEDIPVFPISAVTKTGLREL
LLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFEISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRA
MGVDEALRKRGAKDGDIVRLLDYEFEFMD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=323, Percent_Identity=41.4860681114551, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI111955139, Length=358, Percent_Identity=35.195530726257, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI111955063, Length=189, Percent_Identity=40.2116402116402, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4758796, Length=153, Percent_Identity=35.9477124183007, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=38.0165289256198, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789574, Length=326, Percent_Identity=46.9325153374233, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=36.231884057971, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790615, Length=194, Percent_Identity=30.9278350515464, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=322, Percent_Identity=40.0621118012422, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=311, Percent_Identity=32.475884244373, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=38.9830508474576, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=153, Percent_Identity=33.9869281045752, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=32.3741007194245, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=194, Percent_Identity=38.1443298969072, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=37.3015873015873, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321612, Length=126, Percent_Identity=36.5079365079365, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI20129375, Length=323, Percent_Identity=40.8668730650155, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24585318, Length=376, Percent_Identity=37.2340425531915, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17981711, Length=153, Percent_Identity=34.640522875817, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356473, Length=126, Percent_Identity=35.7142857142857, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 47119; Mature: 47119

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRF
CCCCEEEEEEEECCCCCCEEEEEHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHH
KRIFKAEHGEHGMSKSMHGRGAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAG
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHCCCEEEEEECC
RGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLADVGLVGFPSVGKSTLLSVVSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
ARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVI
CCCCEEEEEHHHHCCCCCEEECCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHEEE
VHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKI
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AEDIPVFPISAVTKTGLRELLLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCE
ISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRAMGVDEALRKRGAKDGDIVRL
ECCCCCCCEEECCCCEEEHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEE
LDYEFEFMD
EECCEEECC
>Mature Secondary Structure
MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRF
CCCCEEEEEEEECCCCCCEEEEEHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHH
KRIFKAEHGEHGMSKSMHGRGAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAG
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHCCCEEEEEECC
RGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLADVGLVGFPSVGKSTLLSVVSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
ARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVI
CCCCEEEEEHHHHCCCCCEEECCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHEEE
VHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKI
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AEDIPVFPISAVTKTGLRELLLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCE
ISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRAMGVDEALRKRGAKDGDIVRL
ECCCCCCCEEECCCCEEEHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEE
LDYEFEFMD
EECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]