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The map label for this gene is pheA [H]

Identifier: 226224137

GI number: 226224137

Start: 1554689

End: 1555537

Strand: Reverse

Name: pheA [H]

Synonym: Lm4b_01546

Alternate gene names: 226224137

Gene position: 1555537-1554689 (Counterclockwise)

Preceding gene: 226224138

Following gene: 226224136

Centisome position: 53.41

GC content: 40.16

Gene sequence:

>849_bases
ATGAAAATTGCTTATTTAGGCCCAGCAGCATCTTTTACACACGCGGCAGCAGCAAAGGCTTTTCCAAAAGAAGAGATGAT
AGCTAAGAGTACGATTCCAGATTGTATTATGGCAATTGAAAAGGAAGACGTGGATGTGGCTGTTGTTCCAATTGAAAATA
CGATTGAAGGAAGCGTCAATATCACGCTGGACTACTTATTTCATTTTTCAAGTGTCCCTGTAGTAGCGGAGATTGTTCTC
CCGATTGCGCAACATTTAATGGTTCATCCAGCACACGTATCCGCTTGGAAATCAGTGAAAAAAGTAATGTCCCACCCACA
AGCACTTGCCCAGTGTCATACATTTCTTCAGGCGGAATTATACGGAGTGGAGCGTGAAGTTACACCTTCAACCGCCTATG
CTGCAAAATGGGTTAGTAATAATCCGACAGAACTTGTCGCAGCTATTGCACCACGCATGGCGGCGAATGAGTACGGGCTT
GAAATCGTCAAAGAAAATGCGCAAGACTTGGAATTAAATCAAACAAGATTTTTTGTTTTAAGTCGTAAACCTGTTTCAAT
TTTATTACCAAAAGAAGAAGAAAAAACGTCTATTTCTGTTATTTTGCCTAACAATATGCCAGGTGCGTTACATAAAGTCT
TATCTACGTTTGCTTGGCGGGATATTGATTTAAGTAAAATCGAATCAAGACCGCTTAAAACCTCATTAGGCGAGTACTTT
TTCTTGATTGATGTACTTTCAGAAGGGAAAGAAACGCTCGTAACTAATGCGCTTGATGAAATAACACTTTTAGGTGGAAC
GGCAAATAAACTTGGAACTTATCACGTTCACCGCTTACAAACGACTTAA

Upstream 100 bases:

>100_bases
CCTGCTTGATTATGAATTTGAATTTATGGATTAAATAAAGTGCTGCGCCAATTAGTTGGCGCACGCTTTTTTCCTAGCTA
CGATAAAAGGAGAGTTGAAA

Downstream 100 bases:

>100_bases
ATAAAGAGTTATCGCAATTTTTTGCGGTAACTTTTTTATTGCGATTCCTCCCTTTTTACGTTAGAATTTGTAGGAGAAAA
GCTTTACTAAATCTAAAAGG

Product: prephenate dehydratase

Products: NA

Alternate protein names: PDT [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKIAYLGPAASFTHAAAAKAFPKEEMIAKSTIPDCIMAIEKEDVDVAVVPIENTIEGSVNITLDYLFHFSSVPVVAEIVL
PIAQHLMVHPAHVSAWKSVKKVMSHPQALAQCHTFLQAELYGVEREVTPSTAYAAKWVSNNPTELVAAIAPRMAANEYGL
EIVKENAQDLELNQTRFFVLSRKPVSILLPKEEEKTSISVILPNNMPGALHKVLSTFAWRDIDLSKIESRPLKTSLGEYF
FLIDVLSEGKETLVTNALDEITLLGGTANKLGTYHVHRLQTT

Sequences:

>Translated_282_residues
MKIAYLGPAASFTHAAAAKAFPKEEMIAKSTIPDCIMAIEKEDVDVAVVPIENTIEGSVNITLDYLFHFSSVPVVAEIVL
PIAQHLMVHPAHVSAWKSVKKVMSHPQALAQCHTFLQAELYGVEREVTPSTAYAAKWVSNNPTELVAAIAPRMAANEYGL
EIVKENAQDLELNQTRFFVLSRKPVSILLPKEEEKTSISVILPNNMPGALHKVLSTFAWRDIDLSKIESRPLKTSLGEYF
FLIDVLSEGKETLVTNALDEITLLGGTANKLGTYHVHRLQTT
>Mature_282_residues
MKIAYLGPAASFTHAAAAKAFPKEEMIAKSTIPDCIMAIEKEDVDVAVVPIENTIEGSVNITLDYLFHFSSVPVVAEIVL
PIAQHLMVHPAHVSAWKSVKKVMSHPQALAQCHTFLQAELYGVEREVTPSTAYAAKWVSNNPTELVAAIAPRMAANEYGL
EIVKENAQDLELNQTRFFVLSRKPVSILLPKEEEKTSISVILPNNMPGALHKVLSTFAWRDIDLSKIESRPLKTSLGEYF
FLIDVLSEGKETLVTNALDEITLLGGTANKLGTYHVHRLQTT

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=277, Percent_Identity=29.6028880866426, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324013, Length=296, Percent_Identity=22.6351351351351, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF00800 PDT [H]

EC number: =4.2.1.51 [H]

Molecular weight: Translated: 31058; Mature: 31058

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAYLGPAASFTHAAAAKAFPKEEMIAKSTIPDCIMAIEKEDVDVAVVPIENTIEGSVN
CEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCCCCEE
ITLDYLFHFSSVPVVAEIVLPIAQHLMVHPAHVSAWKSVKKVMSHPQALAQCHTFLQAEL
EEEEEEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
YGVEREVTPSTAYAAKWVSNNPTELVAAIAPRMAANEYGLEIVKENAQDLELNQTRFFVL
HCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCHHCHHHHHCCCCCCCCCCEEEEEE
SRKPVSILLPKEEEKTSISVILPNNMPGALHKVLSTFAWRDIDLSKIESRPLKTSLGEYF
ECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHH
FLIDVLSEGKETLVTNALDEITLLGGTANKLGTYHVHRLQTT
HHHHHHHCCHHHHHHHHHHHEEEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKIAYLGPAASFTHAAAAKAFPKEEMIAKSTIPDCIMAIEKEDVDVAVVPIENTIEGSVN
CEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCCCCEE
ITLDYLFHFSSVPVVAEIVLPIAQHLMVHPAHVSAWKSVKKVMSHPQALAQCHTFLQAEL
EEEEEEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
YGVEREVTPSTAYAAKWVSNNPTELVAAIAPRMAANEYGLEIVKENAQDLELNQTRFFVL
HCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCHHCHHHHHCCCCCCCCCCEEEEEE
SRKPVSILLPKEEEKTSISVILPNNMPGALHKVLSTFAWRDIDLSKIESRPLKTSLGEYF
ECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHH
FLIDVLSEGKETLVTNALDEITLLGGTANKLGTYHVHRLQTT
HHHHHHHCCHHHHHHHHHHHEEEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2537815; 9384377; 8444804 [H]