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The map label for this gene is hrcA

Identifier: 226224076

GI number: 226224076

Start: 1491492

End: 1492529

Strand: Reverse

Name: hrcA

Synonym: Lm4b_01485

Alternate gene names: 226224076

Gene position: 1492529-1491492 (Counterclockwise)

Preceding gene: 226224077

Following gene: 226224075

Centisome position: 51.24

GC content: 37.38

Gene sequence:

>1038_bases
ATGTTAACAGAAAGACAACTTTTGATTTTTCGTGCCATCATCGATCATTTCACTTGGACTATTCAGCCAGTTGGATCAAA
GAATTTGCTGAAAGAAAAAGGTTTGCCTTATAGTTCCGCGACTATCCGTAATGAAATGGGCGTTCTCGAAGAATACGGTT
TTATTGAAAAGACGCATTCCTCATCGGGACGAGTTCCATCAGAGAAAGGATATCGCTTCTATGTCGATTATTTACTCCAG
CCCAAAAAGCTAGATAAATCCGACAGGCAAATGATTCGTTCCTTCTTTTCAGAGAACTACTACGAAATGGAAGGACTTAT
CCAAAATTCAGCATTAATGTTATCCGATTTAACCAATTACACGTCCATTTTGCTTGGTCCTGAAGCGACGAAAAATCATT
TAAGTGGCTTTAGATTTGTACCAATAAATAATTTTCAAGCAATGCTCATATTAATTACCGATCAAGGGCATGTTGATAAC
CATTTGGTGACAATACCAGAAGGCACAACGCTCTCCGATATTGAACGTATGGTCAACATTCTAAATGAACGGTTAGTAGG
ACTTTCGCTTGATGATTTAAAAGTACAAATACCCATGGAAGTAAAGGAATTACTTGGGAAGCATGTTAGAAATTACGAAA
GCTTTATGCATGTGTTTTCCGATTCTTTTGCTCAAGCAAGTCAACAAAAAGTGTATTTTGGCGGAAAAACGAATATTTTA
AATCAACCGGAATTTCATGACATTAATAAAGTCCGTGAGATGCTTCATTTGATGGAAGAAGAACAAGATGTGTATGAATT
GTTTAGGGATATTCCCGATGGTCTTCAAGTGAAAATTGGCCGAGAAAACAATAATAGTCTAATGGAAGATTGTAGTATCA
TTACAGCAACATATAATATTGCTGGCGAACGCGTTGGCGGTATTGTACTCCTAGGACCCACAAGAATGGAATATAGCAGA
ATGATGGGACTCGTTGATGTGATGAGCCGAGATTTAACCGATGTGTTAACCAAACTTTATCGTGATAACCAAAATTAG

Upstream 100 bases:

>100_bases
TGAAATCGAGTGTTTTCGGTTGACTAAGGTGGAATTGTTTGGTAAATTTATACTTGTATTTAGCACTTGACGTTATGGAG
TGCTAAAAGAGGTGATTGCT

Downstream 100 bases:

>100_bases
GAAGGCTGAAAAAGCACACGTTTTTTCAGGAGGTGGCTAAAGTGTCTGAGAAAAAGAACAAAAAAGAAAGACTAGCTGAT
GAAATCGAACAAGAAGAATT

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHSSSGRVPSEKGYRFYVDYLLQ
PKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNYTSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDN
HLVTIPEGTTLSDIERMVNILNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNIL
NQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNIAGERVGGIVLLGPTRMEYSR
MMGLVDVMSRDLTDVLTKLYRDNQN

Sequences:

>Translated_345_residues
MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHSSSGRVPSEKGYRFYVDYLLQ
PKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNYTSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDN
HLVTIPEGTTLSDIERMVNILNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNIL
NQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNIAGERVGGIVLLGPTRMEYSR
MMGLVDVMSRDLTDVLTKLYRDNQN
>Mature_345_residues
MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHSSSGRVPSEKGYRFYVDYLLQ
PKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNYTSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDN
HLVTIPEGTTLSDIERMVNILNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNIL
NQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNIAGERVGGIVLLGPTRMEYSR
MMGLVDVMSRDLTDVLTKLYRDNQN

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 39682; Mature: 39682

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHS
CCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEECCC
SSGRVPSEKGYRFYVDYLLQPKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNY
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHH
TSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDNHLVTIPEGTTLSDIERMVNI
HHEEECCCHHHHHHCCEEEEEECCCEEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHH
LNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNIL
HHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
NQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHEEEEEEEC
AGERVGGIVLLGPTRMEYSRMMGLVDVMSRDLTDVLTKLYRDNQN
CHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTERQLLIFRAIIDHFTWTIQPVGSKNLLKEKGLPYSSATIRNEMGVLEEYGFIEKTHS
CCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEECCC
SSGRVPSEKGYRFYVDYLLQPKKLDKSDRQMIRSFFSENYYEMEGLIQNSALMLSDLTNY
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHH
TSILLGPEATKNHLSGFRFVPINNFQAMLILITDQGHVDNHLVTIPEGTTLSDIERMVNI
HHEEECCCHHHHHHCCEEEEEECCCEEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHH
LNERLVGLSLDDLKVQIPMEVKELLGKHVRNYESFMHVFSDSFAQASQQKVYFGGKTNIL
HHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
NQPEFHDINKVREMLHLMEEEQDVYELFRDIPDGLQVKIGRENNNSLMEDCSIITATYNI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHEEEEEEEC
AGERVGGIVLLGPTRMEYSRMMGLVDVMSRDLTDVLTKLYRDNQN
CHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]