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The map label for this gene is hemN

Identifier: 226224077

GI number: 226224077

Start: 1492676

End: 1493833

Strand: Reverse

Name: hemN

Synonym: Lm4b_01486

Alternate gene names: 226224077

Gene position: 1493833-1492676 (Counterclockwise)

Preceding gene: 226224078

Following gene: 226224076

Centisome position: 51.29

GC content: 36.7

Gene sequence:

>1158_bases
ATGATAAATACGAACCAATCGAGTAAGGAAAGTTCCGCGGTATATATCCATATTCCGTTTTGCGAACATATTTGCTATTA
CTGCGATTTTAATAAAGTATTCTTAGAAGGACAACCGGTCGACGAATACGTAGATTTACTAATTAAAGAAATGGAATTAA
CTGCTGCAAAAGGACCTATTGCGCCAGTCGACACTGTATTTGTTGGTGGGGGAACGCCTACAACCCTGAACGAAGCGCAA
ATTGCGAGACTTTGCACAGCCATCCATAACATTCTACCGCTCAAAAAAGATATCGAATTTTCCTTTGAAGCCAACCCAGG
AGATCTTTCGCTATCTAAATTACAAGCCATGCAAGATCATCGCGTTAATCGTATCAGTATGGGAGTTCAAAGCTTCAACA
ATGAACTTCTCAAAAAAATTGGACGCATTCATACCGTAAAAGATGTTTATCAATCCGTCGAAAATATGCGCAAAATCGGA
TTTGAAAATGTAAGTATTGATTTAATCTTTAGCTTGCCTGGTCAAACAGAAGCAGATTTCCAAGATACATTAAAACAAGC
GCTTGACCTTGATTTACCGCATTACTCCGCCTATTCATTAATCATCGAACCAAAAACGATTTTTTATAACCTTATGCAAA
AAGGAAAGCTTTTCTTACCTGGTCAAGATGCCGAGGCAAATATGTACGATTTACTTCTCAACGAAATGGAAAAGCACGGT
CGTAAACAATATGAAATTAGTAATTTTGCCAAAGAAGGATTTCAGAGTAAACACAATATCACTTATTGGAGCAATGAACA
TTACTACGGATTTGGCGCCGGAGCACATGGCTATGTTGGCAATACACGTTATAGTAATTTCGGACCAATCAAAAAATACA
TGGAACCACTCCAAAAAAATATACTCCCAACATTCCAACAAAAAGAGCTTACATTAAAAGAAAAAATGGAAGAAGAAATG
TTTTTAGGGCTTAGAAAAGTGGACGGCGTGGATAAAAAACATTTCAAACAAAAATTCGGCCAAGATTTAGATGCAACATT
TGCGAATGCTATTCAAAAAACAACCGCAAAAGGCTGGCTCGAAAATAACGAAGAAAATGTGGCACTTACAAGAAGTGGAA
GATTTTTAGGAAATAATGTTTTTCAAGAATTTCTCTAA

Upstream 100 bases:

>100_bases
TTATTAGATTAAAAGCGAATCCTGCACCAAAGCACTGGAAAATATGTTAAACTGACTAATGGACAACGAAGCAAATTTTA
AGTGCAAGGAATTGATAAAA

Downstream 100 bases:

>100_bases
AACCGCACTATTTGACCTTTTTTGACCAAACAATCCAACTTTAGTCTGAAATCGAGTGTTTTCGGTTGACTAAGGTGGAA
TTGTTTGGTAAATTTATACT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MINTNQSSKESSAVYIHIPFCEHICYYCDFNKVFLEGQPVDEYVDLLIKEMELTAAKGPIAPVDTVFVGGGTPTTLNEAQ
IARLCTAIHNILPLKKDIEFSFEANPGDLSLSKLQAMQDHRVNRISMGVQSFNNELLKKIGRIHTVKDVYQSVENMRKIG
FENVSIDLIFSLPGQTEADFQDTLKQALDLDLPHYSAYSLIIEPKTIFYNLMQKGKLFLPGQDAEANMYDLLLNEMEKHG
RKQYEISNFAKEGFQSKHNITYWSNEHYYGFGAGAHGYVGNTRYSNFGPIKKYMEPLQKNILPTFQQKELTLKEKMEEEM
FLGLRKVDGVDKKHFKQKFGQDLDATFANAIQKTTAKGWLENNEENVALTRSGRFLGNNVFQEFL

Sequences:

>Translated_385_residues
MINTNQSSKESSAVYIHIPFCEHICYYCDFNKVFLEGQPVDEYVDLLIKEMELTAAKGPIAPVDTVFVGGGTPTTLNEAQ
IARLCTAIHNILPLKKDIEFSFEANPGDLSLSKLQAMQDHRVNRISMGVQSFNNELLKKIGRIHTVKDVYQSVENMRKIG
FENVSIDLIFSLPGQTEADFQDTLKQALDLDLPHYSAYSLIIEPKTIFYNLMQKGKLFLPGQDAEANMYDLLLNEMEKHG
RKQYEISNFAKEGFQSKHNITYWSNEHYYGFGAGAHGYVGNTRYSNFGPIKKYMEPLQKNILPTFQQKELTLKEKMEEEM
FLGLRKVDGVDKKHFKQKFGQDLDATFANAIQKTTAKGWLENNEENVALTRSGRFLGNNVFQEFL
>Mature_385_residues
MINTNQSSKESSAVYIHIPFCEHICYYCDFNKVFLEGQPVDEYVDLLIKEMELTAAKGPIAPVDTVFVGGGTPTTLNEAQ
IARLCTAIHNILPLKKDIEFSFEANPGDLSLSKLQAMQDHRVNRISMGVQSFNNELLKKIGRIHTVKDVYQSVENMRKIG
FENVSIDLIFSLPGQTEADFQDTLKQALDLDLPHYSAYSLIIEPKTIFYNLMQKGKLFLPGQDAEANMYDLLLNEMEKHG
RKQYEISNFAKEGFQSKHNITYWSNEHYYGFGAGAHGYVGNTRYSNFGPIKKYMEPLQKNILPTFQQKELTLKEKMEEEM
FLGLRKVDGVDKKHFKQKFGQDLDATFANAIQKTTAKGWLENNEENVALTRSGRFLGNNVFQEFL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=274, Percent_Identity=32.8467153284672, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789325, Length=384, Percent_Identity=31.7708333333333, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI87082341, Length=393, Percent_Identity=26.7175572519084, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43949; Mature: 43949

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTNQSSKESSAVYIHIPFCEHICYYCDFNKVFLEGQPVDEYVDLLIKEMELTAAKGPI
CCCCCCCCCCCCEEEEEEEHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
APVDTVFVGGGTPTTLNEAQIARLCTAIHNILPLKKDIEFSFEANPGDLSLSKLQAMQDH
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
RVNRISMGVQSFNNELLKKIGRIHTVKDVYQSVENMRKIGFENVSIDLIFSLPGQTEADF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCH
QDTLKQALDLDLPHYSAYSLIIEPKTIFYNLMQKGKLFLPGQDAEANMYDLLLNEMEKHG
HHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCC
RKQYEISNFAKEGFQSKHNITYWSNEHYYGFGAGAHGYVGNTRYSNFGPIKKYMEPLQKN
CHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ILPTFQQKELTLKEKMEEEMFLGLRKVDGVDKKHFKQKFGQDLDATFANAIQKTTAKGWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
ENNEENVALTRSGRFLGNNVFQEFL
CCCCCCEEEEECCCHHHHHHHHHHC
>Mature Secondary Structure
MINTNQSSKESSAVYIHIPFCEHICYYCDFNKVFLEGQPVDEYVDLLIKEMELTAAKGPI
CCCCCCCCCCCCEEEEEEEHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
APVDTVFVGGGTPTTLNEAQIARLCTAIHNILPLKKDIEFSFEANPGDLSLSKLQAMQDH
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
RVNRISMGVQSFNNELLKKIGRIHTVKDVYQSVENMRKIGFENVSIDLIFSLPGQTEADF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCH
QDTLKQALDLDLPHYSAYSLIIEPKTIFYNLMQKGKLFLPGQDAEANMYDLLLNEMEKHG
HHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCC
RKQYEISNFAKEGFQSKHNITYWSNEHYYGFGAGAHGYVGNTRYSNFGPIKKYMEPLQKN
CHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ILPTFQQKELTLKEKMEEEMFLGLRKVDGVDKKHFKQKFGQDLDATFANAIQKTTAKGWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
ENNEENVALTRSGRFLGNNVFQEFL
CCCCCCEEEEECCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]