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The map label for this gene is dapA [H]

Identifier: 226224036

GI number: 226224036

Start: 1451017

End: 1451898

Strand: Reverse

Name: dapA [H]

Synonym: Lm4b_01445

Alternate gene names: 226224036

Gene position: 1451898-1451017 (Counterclockwise)

Preceding gene: 226224037

Following gene: 226224035

Centisome position: 49.85

GC content: 38.1

Gene sequence:

>882_bases
ATGGATTTAGGGAAAGTAATTACAGCAATGGTGACACCAATTCACCCAGAGAAAGATAAAGTATGCAAAAAAAGAATTCA
TCATCTCGTGAATCACTTAATCAAAAATGGCTCAGACGGTTTAGTAATCGCTGGAACAACTGGCGAATCTCCAACTTTAT
CCCATGATGAAAAAATAAAATTATTCCGCCAAGTAATTGAAACAAATGACGGACGTGCAAAATTAATTGCTGGAACAGGC
TCCAATAACACAGCTGAAACAATTGCTTTTACAAAAGAAGTTGCTGAACTCGGTGGAATTGACGCTGTTTTAATCGTTGC
ACCGTATTACAATAAACCAAATCAAGATGGGTTATACGCGCACTTTGCTGCGGTTTCTGAAGCTTCTGATTTACCTGTAG
TTATCTATAATATTCCGGGTCGTAGTGTGGTTAATATCGAGCCAGAAACAATTATCCGCCTAGCAAAATTACCTAATATT
GTTGGTGTAAAAGAATCTAGCGGTAACTTGGATAATATAAGTAAAATCATTGCTGAAACCTCAGACGATTTCCAAGTATA
CAGTGGGGATGATAGCTTAACTTTACCAATCCTTGCAGTTGGTGGAAACGGCGTTATTTCTGTTGCTAGCCATGTTGTAG
GAAATGAAATGCAAGAAATGATTCAAGCATTTGAGCGTGGAGAAGTTCAAAAAGCTGCTCAAATCCACCGAGAATTATTG
CCACTCATGAACGGTTTATTCTCTGTACCAAACCCAGCACCGACAAAATATTTACTCAATCAACAAGGCATTAGCGTTGG
GCCTGTAAGACTACCACTTGTAGATTTGAATGCTGAACAAGGAACGAAATTACAAGCTATATTAGAAGGACTTTCTAAAT
AG

Upstream 100 bases:

>100_bases
CTACTATTTGGGTATTAGTAAAAGAAGAGGACTTAATTTCAGCAGTCAATGCCCTTCATGACGTATTTTGTTTGGAAATT
AAGTAAGGAGGAAATGAAAG

Downstream 100 bases:

>100_bases
TTCAAAGGAGGTCTACGCTTTGACAATAAAAAAAGCGAAAAACATAAAAATCATTCCACTCGGCGGTGTCGATGAAAGTG
GCAAAAATTTATATGTAGTA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIKNGSDGLVIAGTTGESPTLSHDEKIKLFRQVIETNDGRAKLIAGTG
SNNTAETIAFTKEVAELGGIDAVLIVAPYYNKPNQDGLYAHFAAVSEASDLPVVIYNIPGRSVVNIEPETIIRLAKLPNI
VGVKESSGNLDNISKIIAETSDDFQVYSGDDSLTLPILAVGGNGVISVASHVVGNEMQEMIQAFERGEVQKAAQIHRELL
PLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK

Sequences:

>Translated_293_residues
MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIKNGSDGLVIAGTTGESPTLSHDEKIKLFRQVIETNDGRAKLIAGTG
SNNTAETIAFTKEVAELGGIDAVLIVAPYYNKPNQDGLYAHFAAVSEASDLPVVIYNIPGRSVVNIEPETIIRLAKLPNI
VGVKESSGNLDNISKIIAETSDDFQVYSGDDSLTLPILAVGGNGVISVASHVVGNEMQEMIQAFERGEVQKAAQIHRELL
PLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK
>Mature_293_residues
MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIKNGSDGLVIAGTTGESPTLSHDEKIKLFRQVIETNDGRAKLIAGTG
SNNTAETIAFTKEVAELGGIDAVLIVAPYYNKPNQDGLYAHFAAVSEASDLPVVIYNIPGRSVVNIEPETIIRLAKLPNI
VGVKESSGNLDNISKIIAETSDDFQVYSGDDSLTLPILAVGGNGVISVASHVVGNEMQEMIQAFERGEVQKAAQIHRELL
PLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=244, Percent_Identity=28.2786885245902, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=26.9102990033223, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1788823, Length=284, Percent_Identity=40.8450704225352, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789620, Length=238, Percent_Identity=31.5126050420168, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082415, Length=273, Percent_Identity=27.4725274725275, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786463, Length=216, Percent_Identity=31.4814814814815, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31420; Mature: 31420

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIKNGSDGLVIAGTTGESPTLSHDEKIK
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
LFRQVIETNDGRAKLIAGTGSNNTAETIAFTKEVAELGGIDAVLIVAPYYNKPNQDGLYA
HHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEE
HFAAVSEASDLPVVIYNIPGRSVVNIEPETIIRLAKLPNIVGVKESSGNLDNISKIIAET
HHHHHCCCCCCCEEEEECCCCEEEEECHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCC
SDDFQVYSGDDSLTLPILAVGGNGVISVASHVVGNEMQEMIQAFERGEVQKAAQIHRELL
CCCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
PLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK
HHHHHHHCCCCCCCCHHHHCCCCCEECCEEEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIKNGSDGLVIAGTTGESPTLSHDEKIK
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
LFRQVIETNDGRAKLIAGTGSNNTAETIAFTKEVAELGGIDAVLIVAPYYNKPNQDGLYA
HHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEE
HFAAVSEASDLPVVIYNIPGRSVVNIEPETIIRLAKLPNIVGVKESSGNLDNISKIIAET
HHHHHCCCCCCCEEEEECCCCEEEEECHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCC
SDDFQVYSGDDSLTLPILAVGGNGVISVASHVVGNEMQEMIQAFERGEVQKAAQIHRELL
CCCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
PLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK
HHHHHHHCCCCCCCCHHHHCCCCCEECCEEEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]