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The map label for this gene is gcvPA [H]

Identifier: 226223950

GI number: 226223950

Start: 1357814

End: 1359160

Strand: Direct

Name: gcvPA [H]

Synonym: Lm4b_01357

Alternate gene names: 226223950

Gene position: 1357814-1359160 (Clockwise)

Preceding gene: 226223949

Following gene: 226223951

Centisome position: 46.62

GC content: 37.94

Gene sequence:

>1347_bases
ATGGCAAAACATCGTTATTTACCAATGACAGAGCAAGATGAAAAGGAAATGCTTGATGTAATAGGGGTTAAGTCAATTGA
TGACTTATTTCAAGATATTCCAGAAAAAATTAGATTTAAACGAGATTATGATTTAAAACCAGCAAAATCAGAACCTGCAC
TTTTACGCGAATTATCGCAACTTGCTTCTAAAAATGCTAATACTACTGAATATGCGTCTTTTTTAGGGGCTGGAGTTTAT
AGTCATTACATTCCAACTGTAGTCGATCACGTTATTTCTCGCTCAGAATTTTATACAGCATATACGCCTTATCAACCTGA
AATTTCTCAAGGAGAGTTGCAGGCAATCTTTGAATTCCAAACGATGATTGCGGAACTTACTGGAATGGACTTGGCTAATT
CCTCTATGTATGATGGTGGAACAGCGCTTGCAGAAGCAGCGATGCTAGCAAGTGGACATACAAAGCGCAAAAAAATTCTC
ATTTCCGGAGCTGTTCACCCGGAAAGTAGCAATGTTTTAAAAACCTATGCAACTGGCCAACACATTGAAGTAGAAGTTAT
TCCAGAACTAGATGGAAAAACAGACATTGAGGCGCTAAAAAAAGCTCTTTCAGATGATATTGCGGGTTTTGTTGTACAAT
ATCCAAACTTCTATGGACAAGTGGAACCTTTGGCTGAACTTGAAAAATTAGTGCATGAAAATAATTCTTTATTACTTGTA
TCGAGCAATCCGTTGTCTCTAGGTTTGTTAACACCACCAGGAGAATTTGGTGCAGATATTGTTGTGGGTGATTCGCAAGT
ATTTGGTATCCCAGAATCATTTGGTGGACCGCATTGTGGATTCTTTGCAGTAACAAATAAATTAATGCGTAAAGTTCCTG
GACGTTTAGTTGGGGAAACCGTAGACGAGAACGGGAAGCGCGGGTATGTACTAACATTACAAGCACGCGAACAACATATT
CGCCGTGATAAAGCGACGTCTAATATTTGTTCCAATCAAGCATTGAATGCATTAGCTTCTTCTGTCGCAATGGCAACCCT
TGGAAAAACAGGTCTTGTAGAAATGGCAAAACAAAACTTAGATAAATCTCATTATGCCAAACAAAAATTCCGTGAAAAAG
GCTTTGAAGTTCTATTTTCAGATGGCTTTTTCAATGAATTTGTTGTAAAACTTTCGAAACCAATCAAAGAAGTGAATGAA
TCACTTTTAGATGAAGGGATTATTGGTGGGTATGACCTTGGTTTTTATGAGGAAAAATATGAAAACCATATGCTTGTAGC
TGTTACTGAAATGCGGACAAAAGAGGAAATTGATGCCTTTGTGGCGAGCTTGGAGGGTGCAAAATGA

Upstream 100 bases:

>100_bases
AGGTCAAGAAGTAGAAGTAGGTATAAGAAACAAAAAAGTAAAAGCGAAAATAGTACCAACACCATTTTATAAACGCGCAA
AGTAAAAAGGAGGAAGTAAT

Downstream 100 bases:

>100_bases
ATTTAGAAGAAACGATGCCATTAGTGTTTGAACGTTCTATTCCAGGAAGAATTGGCTTTAGTTTACCAGAAAGCGATGTT
CCAGAAACAAAAGCCAGTGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSQLASKNANTTEYASFLGAGVY
SHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKIL
ISGAVHPESSNVLKTYATGQHIEVEVIPELDGKTDIEALKKALSDDIAGFVVQYPNFYGQVEPLAELEKLVHENNSLLLV
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMATLGKTGLVEMAKQNLDKSHYAKQKFREKGFEVLFSDGFFNEFVVKLSKPIKEVNE
SLLDEGIIGGYDLGFYEEKYENHMLVAVTEMRTKEEIDAFVASLEGAK

Sequences:

>Translated_448_residues
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSQLASKNANTTEYASFLGAGVY
SHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKIL
ISGAVHPESSNVLKTYATGQHIEVEVIPELDGKTDIEALKKALSDDIAGFVVQYPNFYGQVEPLAELEKLVHENNSLLLV
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMATLGKTGLVEMAKQNLDKSHYAKQKFREKGFEVLFSDGFFNEFVVKLSKPIKEVNE
SLLDEGIIGGYDLGFYEEKYENHMLVAVTEMRTKEEIDAFVASLEGAK
>Mature_447_residues
AKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSQLASKNANTTEYASFLGAGVYS
HYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILI
SGAVHPESSNVLKTYATGQHIEVEVIPELDGKTDIEALKKALSDDIAGFVVQYPNFYGQVEPLAELEKLVHENNSLLLVS
SNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHIR
RDKATSNICSNQALNALASSVAMATLGKTGLVEMAKQNLDKSHYAKQKFREKGFEVLFSDGFFNEFVVKLSKPIKEVNES
LLDEGIIGGYDLGFYEEKYENHMLVAVTEMRTKEEIDAFVASLEGAK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=422, Percent_Identity=39.0995260663507, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1789269, Length=393, Percent_Identity=32.5699745547074, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535605, Length=394, Percent_Identity=39.3401015228426, Blast_Score=270, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323843, Length=419, Percent_Identity=37.9474940334129, Blast_Score=265, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24645648, Length=389, Percent_Identity=40.1028277634961, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49500; Mature: 49369

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSQ
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LASKNANTTEYASFLGAGVYSHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCCCHHHHHHHHH
TMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILISGAVHPESSNVLKTYATGQ
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCC
HIEVEVIPELDGKTDIEALKKALSDDIAGFVVQYPNFYGQVEPLAELEKLVHENNSLLLV
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGET
ECCCCEEEEECCCCCCCCEEEECCCEEECCCHHCCCCCCHHHHHHHHHHHHCCHHHHCCC
VDENGKRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMATLGKTGLVEMAKQNL
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
DKSHYAKQKFREKGFEVLFSDGFFNEFVVKLSKPIKEVNESLLDEGIIGGYDLGFYEEKY
CHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ENHMLVAVTEMRTKEEIDAFVASLEGAK
CCCEEEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSQ
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LASKNANTTEYASFLGAGVYSHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCCCHHHHHHHHH
TMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILISGAVHPESSNVLKTYATGQ
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCC
HIEVEVIPELDGKTDIEALKKALSDDIAGFVVQYPNFYGQVEPLAELEKLVHENNSLLLV
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGET
ECCCCEEEEECCCCCCCCEEEECCCEEECCCHHCCCCCCHHHHHHHHHHHHCCHHHHCCC
VDENGKRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMATLGKTGLVEMAKQNL
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
DKSHYAKQKFREKGFEVLFSDGFFNEFVVKLSKPIKEVNESLLDEGIIGGYDLGFYEEKY
CHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ENHMLVAVTEMRTKEEIDAFVASLEGAK
CCCEEEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]