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The map label for this gene is gcvPB [H]

Identifier: 226223951

GI number: 226223951

Start: 1359157

End: 1360623

Strand: Direct

Name: gcvPB [H]

Synonym: Lm4b_01358

Alternate gene names: 226223951

Gene position: 1359157-1360623 (Clockwise)

Preceding gene: 226223950

Following gene: 226223955

Centisome position: 46.66

GC content: 39.95

Gene sequence:

>1467_bases
ATGAATTTAGAAGAAACGATGCCATTAGTGTTTGAACGTTCTATTCCAGGAAGAATTGGCTTTAGTTTACCAGAAAGCGA
TGTTCCAGAAACAAAAGCCAGTGATTATTTTGAACAAGCGTATATTCGTTCTGTACCAGCAGATTTGCCTGAATTAAGCG
AGCTTGAAATCATGCGTCATTATACCAATTTATCCAATCATAACTTTGGTGTTGATTCTGGTTTTTATCCGCTTGGCTCT
TGTACGATGAAATATAACCCAAAAATCAATGAAAAAGTTGCACGCTTTCCTGGTTTCGCTAATATCCATCCAAACCAACC
AGAAAGCTCTGTCCAAGGCGCGCTAGAACTACTGTATGATTTGCAAACAAGCTTAGTTGAAATTACAGGAATGGATGAAG
TAACGCTACAACCAGCTGCTGGAGCACACGGAGAATGGACGGGATTAATGCTCATTCGTGCATTCCATGAAAAGAATGGG
GATACAAAACGCACAAAAGTAATCATCCCAGACTCTGCACATGGAACAAACCCTGCATCTGCAGCAGTAGCGGGCTTCGA
TGTTGTCACGGTGAAATCGAATGAAAAAGGACTTGTCGATGTAGCTGATTTGAAAAAAGTAGTAGGCGAAGACACGGCCG
CACTAATGCTCACAAACCCAAATACACTTGGTCTTTTTGAAAAAGATATTGTTGAAATGGCGGAAATTGTTCATGAAGCT
GGCGGGAAATTGTACTATGATGGTGCCAATTTAAATGCTATTATGGCGAAAGTTAGACCAGGAGACATGGGCTTTGATGT
TGTTCATTTGAATTTACACAAAACATTTACTGGTCCTCACGGTGGTGGCGGTCCTGGTTCTGGCCCAATTGGCGTGAAAA
AGGAATTAATACCATTCTTACCAACACCAGTCCTTACGAAAAAAGAAGAAGGATACTCGTTTGATTATAACTATCCTGAC
TCTATTGGACGAGTGAAACCTTATTATGGCAACTTCGGCATCAATGTTCGCGCGTATACGTATATTCGCACAATGGGTCC
GGATGGCTTGAAATTGGTGACAGAATATGCCGTTTTAAATGCCAACTATATGATGCGTAAACTGCAAGAAGCCTATGATT
TACCATTTGATCAAGTTTGTAAACACGAATTTGTTTTAAGTGGTAATAGACAGAAGAAACTTGGCGTAAGAACTGTTGAT
ATTGCGAAACGATTGCTAGATCACAATTTCCATCCGCCAACAGTTTATTTCCCGCTAATTGTTGGTGAAGCAATCATGAT
TGAACCGACTGAAACAGAATCGAAAGAAACTCTAGATTCTTTCATTGATACGATGTTAAAAATTGCGAAAGAAGCAGAAG
AAAATCCTGAAATCGTCCAAGAAGCGCCACATAGCACCTATGTAAAACGACTAGACGAAACACGTGCTGCTAGAAAACCG
ATTTTACGTTATCAAAAAGAAGTATAA

Upstream 100 bases:

>100_bases
TTTATGAGGAAAAATATGAAAACCATATGCTTGTAGCTGTTACTGAAATGCGGACAAAAGAGGAAATTGATGCCTTTGTG
GCGAGCTTGGAGGGTGCAAA

Downstream 100 bases:

>100_bases
AAAAACCTTGCTGTGAATTTCCGCAGCAAGGTTTTTTCTTATTTAGATTTAGTTTTTCCTGTCCATTTACGGTAGCCGCC
TTTAAGCTGATAAACTTGTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDYFEQAYIRSVPADLPELSELEIMRHYTNLSNHNFGVDSGFYPLGS
CTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYDLQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNG
DTKRTKVIIPDSAHGTNPASAAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHEA
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFLPTPVLTKKEEGYSFDYNYPD
SIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLNANYMMRKLQEAYDLPFDQVCKHEFVLSGNRQKKLGVRTVD
IAKRLLDHNFHPPTVYFPLIVGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
ILRYQKEV

Sequences:

>Translated_488_residues
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDYFEQAYIRSVPADLPELSELEIMRHYTNLSNHNFGVDSGFYPLGS
CTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYDLQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNG
DTKRTKVIIPDSAHGTNPASAAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHEA
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFLPTPVLTKKEEGYSFDYNYPD
SIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLNANYMMRKLQEAYDLPFDQVCKHEFVLSGNRQKKLGVRTVD
IAKRLLDHNFHPPTVYFPLIVGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
ILRYQKEV
>Mature_488_residues
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDYFEQAYIRSVPADLPELSELEIMRHYTNLSNHNFGVDSGFYPLGS
CTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYDLQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNG
DTKRTKVIIPDSAHGTNPASAAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHEA
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFLPTPVLTKKEEGYSFDYNYPD
SIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLNANYMMRKLQEAYDLPFDQVCKHEFVLSGNRQKKLGVRTVD
IAKRLLDHNFHPPTVYFPLIVGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
ILRYQKEV

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=429, Percent_Identity=43.1235431235431, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1789269, Length=430, Percent_Identity=41.6279069767442, Blast_Score=291, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17535605, Length=413, Percent_Identity=42.3728813559322, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI32564013, Length=370, Percent_Identity=43.5135135135135, Blast_Score=264, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6323843, Length=428, Percent_Identity=43.4579439252336, Blast_Score=322, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=42.4757281553398, Blast_Score=294, Evalue=7e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54186; Mature: 54186

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDYFEQAYIRSVPADLPELSELEIMRH
CCCHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
YTNLSNHNFGVDSGFYPLGSCTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYD
HHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNGDTKRTKVIIPDSAHGTNPAS
HHHHHEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHH
AAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHEA
HHEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFL
CCEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCC
PTPVLTKKEEGYSFDYNYPDSIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLN
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
ANYMMRKLQEAYDLPFDQVCKHEFVLSGNRQKKLGVRTVDIAKRLLDHNFHPPTVYFPLI
HHHHHHHHHHHHCCCHHHHHCHHHEECCCCCHHCCCCHHHHHHHHHHCCCCCCEEEEHHH
VGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
HCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
ILRYQKEV
HHHHHCCC
>Mature Secondary Structure
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDYFEQAYIRSVPADLPELSELEIMRH
CCCHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
YTNLSNHNFGVDSGFYPLGSCTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYD
HHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNGDTKRTKVIIPDSAHGTNPAS
HHHHHEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHH
AAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHEA
HHEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFL
CCEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCC
PTPVLTKKEEGYSFDYNYPDSIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLN
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
ANYMMRKLQEAYDLPFDQVCKHEFVLSGNRQKKLGVRTVDIAKRLLDHNFHPPTVYFPLI
HHHHHHHHHHHHCCCHHHHHCHHHEECCCCCHHCCCCHHHHHHHHHHCCCCCCEEEEHHH
VGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
HCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
ILRYQKEV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]