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The map label for this gene is aroE

Identifier: 226223116

GI number: 226223116

Start: 524271

End: 525146

Strand: Direct

Name: aroE

Synonym: Lm4b_00513

Alternate gene names: 226223116

Gene position: 524271-525146 (Clockwise)

Preceding gene: 226223115

Following gene: 226223117

Centisome position: 18.0

GC content: 39.27

Gene sequence:

>876_bases
ATGACAAACAAAATCACAGAAAGAATTACAGGACACACAGAATTAATCGGTTTAATCGCCACTCCAATCAGACACAGTTT
ATCACCAACAATGCATAATGAAGCTTTTGCAAAACTCGGGCTTGATTATGTATACCTTGCTTTTGAAGTTGGAGACAAAG
AACTGAAAGATGTTGTACAAGGATTCCGCGCAATGAACTTACGCGGCTGGAACGTTTCCATGCCAAATAAAACAAATATC
CATAAATATTTAGATAAACTTTCTCCAGCAGCTGAACTTGTAGGGGCAGTAAATACAGTTGTTAATGATGACGGCGTGTT
AACTGGACACATTACTGACGGCACTGGATACATGCGTGCATTAAAAGAAGCTGGACATGACATTATCGGCAAAAAAATGA
CGATTTGCGGCGCTGGTGGTGCGGCAACAGCTATTTGTATCCAAGCTGCTCTTGACGGCGTAAAAGAAATTTCTATTTTC
AACAGAAAAGACGATTTTTACGCGAATGCAGAAAAAACAGTAGAAAAAATCAATTCGAAAACAGATTGTAAAGCACAATT
ATTTGATATCGAAGACCACGAACAATTACGTAAAGAAATTGCAGAAAGTGTTATTTTCACGAATGCGACTGGCGTTGGGA
TGAAACCTTTCGAAGGCGAAACACTTCTACCAAGTGCGGATATGCTTCGTCCAGAATTAATCGTTTCGGATGTTGTCTAC
AAACCAACCAAAACAAGATTGCTTGAAATCGCCGAAGAACAAGGCTGTCAAACACTTAACGGTCTAGGCATGATGCTTTG
GCAAGGTGCGAAAGCTTTCGAAATTTGGACACACAAAGAAATGCCAGTGGATTACATTAAAGAAATCCTATTTTAA

Upstream 100 bases:

>100_bases
ATCCGAACTGGCAAGGCGGAGTCCGTCTTGCCACATTCGCTCTTTATATAAGTTCACATTTTCACAAATAAACCTTAATT
TGGAAAGGAACGATGTTATT

Downstream 100 bases:

>100_bases
AAACTTGCAAAAGAACAAGGTTATCGCTAATCTTAAGACATAATATCGAATGAGGAGAATTATACATGAATAAAGTAGTC
GTAAAGAATGTTACGTTTGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTNKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNI
HKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIF
NRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVY
KPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF

Sequences:

>Translated_291_residues
MTNKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNI
HKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIF
NRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVY
KPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF
>Mature_290_residues
TNKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNIH
KYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFN
RKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVYK
PTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=48.936170212766, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1789675, Length=273, Percent_Identity=27.8388278388278, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=285, Percent_Identity=28.7719298245614, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 32161; Mature: 32030

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQ
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHH
GFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRA
HHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
LKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFNRKDDFYANAEKTVEKINSK
HHHCCHHHHCCEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCHHCCHHHHHHHHCCC
TDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVY
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHC
KPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF
CCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHC
>Mature Secondary Structure 
TNKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQ
CCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHH
GFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRA
HHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
LKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFNRKDDFYANAEKTVEKINSK
HHHCCHHHHCCEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCHHCCHHHHHHHHCCC
TDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVY
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHC
KPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF
CCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]