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The map label for this gene is proC [H]

Identifier: 226223020

GI number: 226223020

Start: 419373

End: 420173

Strand: Reverse

Name: proC [H]

Synonym: Lm4b_00414

Alternate gene names: 226223020

Gene position: 420173-419373 (Counterclockwise)

Preceding gene: 226223040

Following gene: 226223014

Centisome position: 14.43

GC content: 41.2

Gene sequence:

>801_bases
ATGAAGAAAATCGGCTTTATTGGCGCAGGTAATATGGGAACTGCGATGATTCGGGGCTTAGCACAAGCGAATTTAGATAA
CAGCGAAGCAATCATTGTTGGTGGTCGAAATCTCGAAAAATTAAAACCACTGGAAGCGGCATTTACTGGCCTGCAAATAA
CAACCGATACCGAAAAACTCGTAGAACAAGCAGATATTATTATTTTAGCGGTGAAACCTTACACTATCCCAGAAATTTTA
ACGTCGGTAAAAGAGCAGCTAACACCTGATAAAATTGTTATTTCTGTAGCAGCTGGCGTAACTATCCAAGATTTAGAAGA
ACTCACTTCCGCAAAAACAAAAATTGTTCGTGTGATGCCAAATACACCAGCGCTTGTCGGTGAAGCAATGTCATCTATTT
CGCCTAACATAAACGTATCATCTGAAGAAATTAATGAAGTTACAGCTATTTTTACTAGTTTTGGAGAAGCGGAAGTTGTT
TCCGAGAATTTGATGGATGCAGTTATTGGCGTCAGTGGTTCTTCACCAGCTTATGTTTATATGTTCATAGAAGCTTTAGC
AGACGGCGCCGTCCTAAGTGGCATGCCTCGCGATAAAGCATATAAATTCGCCGCACAAGCTGTGCTAGGTGCCGCAAAAA
CGGTTCTAGAAACCGGCGAACATCCAGGTAAACTTAAAGATATGGTTACTTCTCCCGGCGGAACTACAATTGAAGCCGTG
AAATCACTAGAAAATGATGGTTTCCGTTCCGCTGTTATCAATGCAGTTCAAGCTGCTGCAAAGAAAAATAGTTCGATGTA
A

Upstream 100 bases:

>100_bases
AATAAGCCCCTGTGACACAGTGATAGCCTTCAGCAAAAACTGGACAAAGCCGTGTAACATGAGATAATAGAAAAAAAGAA
TTTTGTTAGGGGCGAATAAA

Downstream 100 bases:

>100_bases
TTCTATAAATATTTAATAAAAAAGTACTTTTCTTCTCCTATTATAGGAAAATCTTTTACACGTCCAAGCTCAGTAAAACC
GCATTTTTTATAAAATCCTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKKIGFIGAGNMGTAMIRGLAQANLDNSEAIIVGGRNLEKLKPLEAAFTGLQITTDTEKLVEQADIIILAVKPYTIPEIL
TSVKEQLTPDKIVISVAAGVTIQDLEELTSAKTKIVRVMPNTPALVGEAMSSISPNINVSSEEINEVTAIFTSFGEAEVV
SENLMDAVIGVSGSSPAYVYMFIEALADGAVLSGMPRDKAYKFAAQAVLGAAKTVLETGEHPGKLKDMVTSPGGTTIEAV
KSLENDGFRSAVINAVQAAAKKNSSM

Sequences:

>Translated_266_residues
MKKIGFIGAGNMGTAMIRGLAQANLDNSEAIIVGGRNLEKLKPLEAAFTGLQITTDTEKLVEQADIIILAVKPYTIPEIL
TSVKEQLTPDKIVISVAAGVTIQDLEELTSAKTKIVRVMPNTPALVGEAMSSISPNINVSSEEINEVTAIFTSFGEAEVV
SENLMDAVIGVSGSSPAYVYMFIEALADGAVLSGMPRDKAYKFAAQAVLGAAKTVLETGEHPGKLKDMVTSPGGTTIEAV
KSLENDGFRSAVINAVQAAAKKNSSM
>Mature_266_residues
MKKIGFIGAGNMGTAMIRGLAQANLDNSEAIIVGGRNLEKLKPLEAAFTGLQITTDTEKLVEQADIIILAVKPYTIPEIL
TSVKEQLTPDKIVISVAAGVTIQDLEELTSAKTKIVRVMPNTPALVGEAMSSISPNINVSSEEINEVTAIFTSFGEAEVV
SENLMDAVIGVSGSSPAYVYMFIEALADGAVLSGMPRDKAYKFAAQAVLGAAKTVLETGEHPGKLKDMVTSPGGTTIEAV
KSLENDGFRSAVINAVQAAAKKNSSM

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=38.3458646616541, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=38.3458646616541, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=39.9253731343284, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=37.1212121212121, Blast_Score=186, Evalue=1e-47,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=51.6981132075472, Blast_Score=263, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=38.0228136882129, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=37.1428571428571, Blast_Score=161, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320861, Length=206, Percent_Identity=35.4368932038835, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=39.9280575539568, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21358587, Length=257, Percent_Identity=40.0778210116732, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24647700, Length=161, Percent_Identity=45.9627329192547, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27886; Mature: 27886

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIGFIGAGNMGTAMIRGLAQANLDNSEAIIVGGRNLEKLKPLEAAFTGLQITTDTEKL
CCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEECCHHHH
VEQADIIILAVKPYTIPEILTSVKEQLTPDKIVISVAAGVTIQDLEELTSAKTKIVRVMP
HHHCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEECC
NTPALVGEAMSSISPNINVSSEEINEVTAIFTSFGEAEVVSENLMDAVIGVSGSSPAYVY
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHH
MFIEALADGAVLSGMPRDKAYKFAAQAVLGAAKTVLETGEHPGKLKDMVTSPGGTTIEAV
HHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
KSLENDGFRSAVINAVQAAAKKNSSM
HHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKIGFIGAGNMGTAMIRGLAQANLDNSEAIIVGGRNLEKLKPLEAAFTGLQITTDTEKL
CCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEECCHHHH
VEQADIIILAVKPYTIPEILTSVKEQLTPDKIVISVAAGVTIQDLEELTSAKTKIVRVMP
HHHCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEECC
NTPALVGEAMSSISPNINVSSEEINEVTAIFTSFGEAEVVSENLMDAVIGVSGSSPAYVY
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHH
MFIEALADGAVLSGMPRDKAYKFAAQAVLGAAKTVLETGEHPGKLKDMVTSPGGTTIEAV
HHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
KSLENDGFRSAVINAVQAAAKKNSSM
HHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]