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The map label for this gene is folA

Identifier: 226222854

GI number: 226222854

Start: 230100

End: 230474

Strand: Direct

Name: folA

Synonym: Lm4b_00223

Alternate gene names: 226222854

Gene position: 230100-230474 (Clockwise)

Preceding gene: 226222853

Following gene: 226222855

Centisome position: 7.9

GC content: 36.8

Gene sequence:

>375_bases
TTGGATAAAATTTATTTAAATGAATTAGTGTTTTACGGATACCATGGAGTTTTGGCGGAAGAAACAAAACTAGGACAAAC
GTTTAGAGTATCGCTTATTCTCGGCCTTTCTACTAAAAAAGCAGGAATATCGGATAGCGTAGACGACACAGTCAGCTATG
CAGAAGTTTATGAAACGGTAAAAGAAATAGTGGAAGGAACGCCATTCAAATTAATCGAGGCGCTTGCCGAAAAAATTGCA
ACGGAAGTTTTAACTGGTTATCCTCTATTAGAAGAAGTGACTGTAAAACTTATTAAACCAAATCCTCCGATTCCGGGACA
TTATGATTCTGTTGCAGTGGAAATTGAACGTAAAAGAAGTGATTTGAATGGCTAA

Upstream 100 bases:

>100_bases
ACTCGTGTACACGATGTACTTCCAATTGCGCGCATGGTAAGAATGACAGACGCGATTACGGGCAAATTAGATATTACAAA
ATTATAAAGAGGTGCTTTAG

Downstream 100 bases:

>100_bases
GGTGTTTCTATCAATTGGTACAAACCTTGGCGAACGTTTAGAAAATTTAAATGACGCACTAAGTGGTTTAGCTGCTTCAG
ATAAAATTAAAATTACCAAC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MDKIYLNELVFYGYHGVLAEETKLGQTFRVSLILGLSTKKAGISDSVDDTVSYAEVYETVKEIVEGTPFKLIEALAEKIA
TEVLTGYPLLEEVTVKLIKPNPPIPGHYDSVAVEIERKRSDLNG

Sequences:

>Translated_124_residues
MDKIYLNELVFYGYHGVLAEETKLGQTFRVSLILGLSTKKAGISDSVDDTVSYAEVYETVKEIVEGTPFKLIEALAEKIA
TEVLTGYPLLEEVTVKLIKPNPPIPGHYDSVAVEIERKRSDLNG
>Mature_124_residues
MDKIYLNELVFYGYHGVLAEETKLGQTFRVSLILGLSTKKAGISDSVDDTVSYAEVYETVKEIVEGTPFKLIEALAEKIA
TEVLTGYPLLEEVTVKLIKPNPPIPGHYDSVAVEIERKRSDLNG

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13731; Mature: 13731

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIYLNELVFYGYHGVLAEETKLGQTFRVSLILGLSTKKAGISDSVDDTVSYAEVYETV
CCCHHHHHHHHHCCCCHHHCHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
KEIVEGTPFKLIEALAEKIATEVLTGYPLLEEVTVKLIKPNPPIPGHYDSVAVEIERKRS
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHC
DLNG
CCCC
>Mature Secondary Structure
MDKIYLNELVFYGYHGVLAEETKLGQTFRVSLILGLSTKKAGISDSVDDTVSYAEVYETV
CCCHHHHHHHHHCCCCHHHCHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
KEIVEGTPFKLIEALAEKIATEVLTGYPLLEEVTVKLIKPNPPIPGHYDSVAVEIERKRS
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHC
DLNG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]