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The map label for this gene is sul

Identifier: 226222853

GI number: 226222853

Start: 229271

End: 230086

Strand: Direct

Name: sul

Synonym: Lm4b_00222

Alternate gene names: 226222853

Gene position: 229271-230086 (Clockwise)

Preceding gene: 226222852

Following gene: 226222854

Centisome position: 7.87

GC content: 42.03

Gene sequence:

>816_bases
TTGAAGAAGTGGAAAAGGGATCACTTAGGTATGGTCATGGGGATACTGAATGTTACGCCAGACTCTTTTTCGGATGGCGG
GAAATATATGCAAGTGGAAGAAGCTGTGGCTCGAGCGTTACAAATGGCAGAAGATGGAGCAGCAATTATTGACGTTGGTG
GAATATCTACTCGGCCTGGTTTTTCAGAGGTAACGCCTGAGGAAGAACTTAATCGAATTATTCCTGTCATTAAAGCTGTT
AGGACAAAACTTCCGGATATATGGATTTCTGTTGATACTTGGCGTGCCGAAGTGGCTGAAAAAGCTATTTTAGCAGGAGC
TAATATGATAAATGATCAATGGGGTGCCAAAAAAGAACCGAAAATTGCTGAAGTAGCTGCGAAATATAACGTGCCAATTT
GTTTGATGCACAACCGAGAAAACACGCAATACGATAATTTTCTGGAAGATGTGAAGAAAGACTTATTAGAAAGTGTTGCA
ATTGCTAAAGCGGCATCCGTGCCAGATGAACATATTATTCTTGATCCGGGTTTCGGTTTTGTTAAGACGCCTGCGCAGAA
TTTAGAAGTGTTACGACGCATTGATGAGATAGTGGCGCTTGGTTACGAGGTTTTACTTGGTACGAGTAGAAAGTCGACAA
TTGGTCTCGTCTTAGGAACTACTCCAGAGGATAGAATGGAAGGAACTGGGGCGACAACCGTTTACGGATTTTCGAAAGGT
TGCACAATTACTCGTGTACACGATGTACTTCCAATTGCGCGCATGGTAAGAATGACAGACGCGATTACGGGCAAATTAGA
TATTACAAAATTATAA

Upstream 100 bases:

>100_bases
TTTTGACCGATGCGGTTTACTCCCTTTTCCGCATCGGTTTTTTTGTGCGCTAAAATCACTGAATTCTGCTATAATAAATC
TCGGAAAGAGGTGTTTGGGC

Downstream 100 bases:

>100_bases
AGAGGTGCTTTAGTTGGATAAAATTTATTTAAATGAATTAGTGTTTTACGGATACCATGGAGTTTTGGCGGAAGAAACAA
AACTAGGACAAACGTTTAGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPGFSEVTPEEELNRIIPVIKAV
RTKLPDIWISVDTWRAEVAEKAILAGANMINDQWGAKKEPKIAEVAAKYNVPICLMHNRENTQYDNFLEDVKKDLLESVA
IAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFSKG
CTITRVHDVLPIARMVRMTDAITGKLDITKL

Sequences:

>Translated_271_residues
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPGFSEVTPEEELNRIIPVIKAV
RTKLPDIWISVDTWRAEVAEKAILAGANMINDQWGAKKEPKIAEVAAKYNVPICLMHNRENTQYDNFLEDVKKDLLESVA
IAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFSKG
CTITRVHDVLPIARMVRMTDAITGKLDITKL
>Mature_271_residues
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPGFSEVTPEEELNRIIPVIKAV
RTKLPDIWISVDTWRAEVAEKAILAGANMINDQWGAKKEPKIAEVAAKYNVPICLMHNRENTQYDNFLEDVKKDLLESVA
IAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFSKG
CTITRVHDVLPIARMVRMTDAITGKLDITKL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=257, Percent_Identity=42.8015564202335, Blast_Score=202, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=30.9375, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29763; Mature: 29763

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
FSEVTPEEELNRIIPVIKAVRTKLPDIWISVDTWRAEVAEKAILAGANMINDQWGAKKEP
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
KIAEVAAKYNVPICLMHNRENTQYDNFLEDVKKDLLESVAIAKAASVPDEHIILDPGFGF
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
VKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFSKG
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCHHHHCCCCCEEEEECCCC
CTITRVHDVLPIARMVRMTDAITGKLDITKL
CEEEHHHHHHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
FSEVTPEEELNRIIPVIKAVRTKLPDIWISVDTWRAEVAEKAILAGANMINDQWGAKKEP
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
KIAEVAAKYNVPICLMHNRENTQYDNFLEDVKKDLLESVAIAKAASVPDEHIILDPGFGF
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
VKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFSKG
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCHHHHCCCCCEEEEECCCC
CTITRVHDVLPIARMVRMTDAITGKLDITKL
CEEEHHHHHHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]