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The map label for this gene is mpl

Identifier: 226222832

GI number: 226222832

Start: 204432

End: 205964

Strand: Direct

Name: mpl

Synonym: Lm4b_00201

Alternate gene names: 226222832

Gene position: 204432-205964 (Clockwise)

Preceding gene: 226222831

Following gene: 226222833

Centisome position: 7.02

GC content: 38.36

Gene sequence:

>1533_bases
ATGAAGAGTAAACTTATTTGTATCATCATGGTAATAGCTTTTCAGGCTCATTTCAATATGGCGGTAAAAGCGGATTCTGT
CGGGGAAGAAAGGCTCCGAAATGATATACAAGCCAAAAGGAACCCTGCTGATTTAAAAGCTTTGCCAGATTCCTGCGAAG
CAAAAGATTTTTATAAAAATTTTAAAATTCTTGATATGACAAAAGATAAGCTAGGCGTTACGCATTATACGCTCGCGCTA
AGTTCTGATGGTTACTTGACTGATAATGATGAAATAAAGGTCCACGTCACACCGGATAATAAAATCACTTTTATAAATGG
AGATTTACAGCAAGGGCAGCTTAGGATTACTAATCAAATAAAAATCACAGAAAAAAATGCTATTGAAAAAGCATTTGAAG
CCATTGGTCAGAGTGAAGCTCATGTGAAAAGTTATATTGGAAATCCAGTGAAAGAAAAAGAAATCATCATCAATTCCAGA
ACGAAACGCTTAGTTTATAATATAAAATTGATTTTTGCTGAGCCGGAAGTTGCGAGTTGGATTATTCAAGTGGATGCAGA
AACCGGCGCAATTTTAAAAAAACAAAATATGCTTTCCGAGGTAGAGCGGGCTGATACCCACAAAGATTTTCAAGCGCTTG
GTAAAGGAGCTAACCGATTACTCCAGAGACCATTACATGTCATGAAAATAAATGACCTGTTTTACTTAGTGGATAGAACT
CATAAAGGACTCATAAGAACTTTTGATTTAAACCATAAAACGGACGCATCTTTTGGAAAAGTGGTGTCGAATAAAACGAA
TATGTTTACGGATCCGGAATTTAGTTCCGCGGTGGATGCTCATTTTTACGCAAGTGAAGTGTACGATTACTATAAAAATG
TCCATCAACTAGAGAGTCTAGATGGTAAAGGTGGAGAAATTGATTCGTTTGTTCATTATGGCTTGAATTGCAATAATGCT
TTTTGGGATGGCCGAGAAATTCTTTATGGAGATGGGGACAAAAAGAATTTCAAACCATTTTCATGCGCCAAAACGATTGT
TGGTCATGAACTAACGCATGCGGTTATCCAGTATTCGGCAGGATTAGAATACGAAGGGCAATCAGGTGCGCTAAACGAAT
CGTTCGCCGATGTCTTTGGTTATTTTATTGCGCCAAATCATTGGTTGATTGGTGAGGATGTCTGTGTGCGTGGGTTACGA
GATGGGCGAATAAGAAGCATCAAAGATCCTGACAAATATAATCAAGCGGCTCATATGAAGGATTATGAATCGCTTCCAAT
CACAGAGGAAGGCGACTGGGGCGGAGTTCATTTTAATAGTGGTATACCGAATAAAGCAGCCTACAATACGATCACTAAAC
TTGGAAAAGAAAAAACAGAACAACTTTACTTCCGCGCCTTAAAGTACTATTTAACAAAAAAAGCCCAGTTTACCGATGCG
AAAAAAGCACTCCAACAAGCGGCGAAAGATTTATATGGTGAAGATGCTTCTAAAAAAGTTGCGGAAGCTTGGGAAGCGGT
CGGAGTTAACTGA

Upstream 100 bases:

>100_bases
TAGTTCCCACATATGCTAAAAAACGTGTCCTTAACTCTCTCTGTCAGATTAGTTGTAGGTGGCTTAAACTTACTTTTACG
AATTGAAAAGGAGCGGTGAA

Downstream 100 bases:

>100_bases
TTAACAAATGTTAGAGAAAACTTAATTCTTCAAGTGATATTCTTAAAATAATTCATGAATATTTTTTTCTTAAATTAGCT
AATTAAGAAGATAACCAACT

Product: Zinc metalloproteinase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKSKLICIIMVIAFQAHFNMAVKADSVGEERLRNDIQAKRNPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLAL
SSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYIGNPVKEKEIIINSR
TKRLVYNIKLIFAEPEVASWIIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRT
HKGLIRTFDLNHKTDASFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYDYYKNVHQLESLDGKGGEIDSFVHYGLNCNNA
FWDGREILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGLR
DGRIRSIKDPDKYNQAAHMKDYESLPITEEGDWGGVHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDA
KKALQQAAKDLYGEDASKKVAEAWEAVGVN

Sequences:

>Translated_510_residues
MKSKLICIIMVIAFQAHFNMAVKADSVGEERLRNDIQAKRNPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLAL
SSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYIGNPVKEKEIIINSR
TKRLVYNIKLIFAEPEVASWIIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRT
HKGLIRTFDLNHKTDASFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYDYYKNVHQLESLDGKGGEIDSFVHYGLNCNNA
FWDGREILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGLR
DGRIRSIKDPDKYNQAAHMKDYESLPITEEGDWGGVHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDA
KKALQQAAKDLYGEDASKKVAEAWEAVGVN
>Mature_510_residues
MKSKLICIIMVIAFQAHFNMAVKADSVGEERLRNDIQAKRNPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLAL
SSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYIGNPVKEKEIIINSR
TKRLVYNIKLIFAEPEVASWIIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRT
HKGLIRTFDLNHKTDASFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYDYYKNVHQLESLDGKGGEIDSFVHYGLNCNNA
FWDGREILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGLR
DGRIRSIKDPDKYNQAAHMKDYESLPITEEGDWGGVHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDA
KKALQQAAKDLYGEDASKKVAEAWEAVGVN

Specific function: Probably linked to the pathogenesis of listerial infection [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: NA

Molecular weight: Translated: 57541; Mature: 57541

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKLICIIMVIAFQAHFNMAVKADSVGEERLRNDIQAKRNPADLKALPDSCEAKDFYKN
CCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHCC
FKILDMTKDKLGVTHYTLALSSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQI
CEEEEECCHHCCCEEEEEEECCCCEECCCCCEEEEECCCCEEEEEECCCCCCCEEEEEEE
KITEKNAIEKAFEAIGQSEAHVKSYIGNPVKEKEIIINSRTKRLVYNIKLIFAEPEVASW
EEEHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCEEEEEEEEEEEECCCCEEE
IIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRT
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCEEEEEECC
HKGLIRTFDLNHKTDASFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYDYYKNVHQLESL
CCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGKGGEIDSFVHYGLNCNNAFWDGREILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSA
CCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGLRDGRIRSIKDPDKYNQAAHMK
CCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCHHHHCCCCCCCCCCCCCCHHHCCHHHCC
DYESLPITEEGDWGGVHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDA
CCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KKALQQAAKDLYGEDASKKVAEAWEAVGVN
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSKLICIIMVIAFQAHFNMAVKADSVGEERLRNDIQAKRNPADLKALPDSCEAKDFYKN
CCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHCC
FKILDMTKDKLGVTHYTLALSSDGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQI
CEEEEECCHHCCCEEEEEEECCCCEECCCCCEEEEECCCCEEEEEECCCCCCCEEEEEEE
KITEKNAIEKAFEAIGQSEAHVKSYIGNPVKEKEIIINSRTKRLVYNIKLIFAEPEVASW
EEEHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCEEEEEEEEEEEECCCCEEE
IIQVDAETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRT
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCEEEEEECC
HKGLIRTFDLNHKTDASFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYDYYKNVHQLESL
CCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGKGGEIDSFVHYGLNCNNAFWDGREILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSA
CCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGLRDGRIRSIKDPDKYNQAAHMK
CCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCHHHHCCCCCCCCCCCCCCHHHCCHHHCC
DYESLPITEEGDWGGVHFNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKAQFTDA
CCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KKALQQAAKDLYGEDASKKVAEAWEAVGVN
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1898903; 11679669 [H]