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The map label for this gene is exuR [H]

Identifier: 225859887

GI number: 225859887

Start: 2049800

End: 2050516

Strand: Reverse

Name: exuR [H]

Synonym: SP70585_2240

Alternate gene names: 225859887

Gene position: 2050516-2049800 (Counterclockwise)

Preceding gene: 225859888

Following gene: 225859886

Centisome position: 93.86

GC content: 41.7

Gene sequence:

>717_bases
ATGGCGAAACCCTTGGTAGAAAAAGCATCAGAACGCTTATTGGAATTGATTTTGGAAAGAGGATATGAGGTTGGAGACAA
GCTTCCAAATGAGTATGAATTAGCCCAAGATTTAGAAGTTGGACGTTCGACTGTTCGTGAAGCTGTTCGGAGTTTGGCTA
CTCGCAATATTCTGGAGGTGCGCCAAGGGTCAGGGACATACATCAGCTCTAAAAAAGGAGTATCGGAAGACCCTCTAGGT
TTTTCTTTGGTAAGAGACCGTGTGAAGTTGACAACGGATTTGTTTGAAGTGCGGTACTTACTTGAACCGAGAATTGCGGA
GCGTGTAGCTCAATTTGCTTCGGATGAAGATGTTGCTAAATTAGAGGAAATTGTCCTTGCAATTGAAGAGGCTGTAGCTG
CTGGAGACACGAAGCATTTGGAGTTGGATGTGAAATTTCATTGTATGCTGGCTGAGATGAGTGGGAATCTGGCAATGACT
AGCCTGATGCCTGTCATTAATCAGTCCATTCATCTGATCAATGAAAATTACTCAAATCGTCAGATGAAATCAAATAGTTT
ACAGGCGCACAGAAATATCTTAATGGCAATCAAACAACGCCACCCTGTTGCAGCTTATGATAGTATGTTAGCGCATATTA
TATCGGTAAGACAGGTTGTTTTAAGCGAATGGTTCGATAAAGACATGACCTTGCATGGTCTAAATGATCATAAATAG

Upstream 100 bases:

>100_bases
AGAAATAAAGAAACGTTGGACTGCCATTCCAAACTACCATTATAAAAGGAAATAGGCTATAATAGTAGCAAATAGAAAGT
TGTATTGGAGGACCAAGCAC

Downstream 100 bases:

>100_bases
AAATATAAAACGAACTGCCCAGAAGAGTCTTCTGGGTATTTTTTTGCTTTTTCCTTGACAAATCATCTGATGAATTATAT
ACTATAACTATAAATAGCAA

Product: transcriptional regulator, GntR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MAKPLVEKASERLLELILERGYEVGDKLPNEYELAQDLEVGRSTVREAVRSLATRNILEVRQGSGTYISSKKGVSEDPLG
FSLVRDRVKLTTDLFEVRYLLEPRIAERVAQFASDEDVAKLEEIVLAIEEAVAAGDTKHLELDVKFHCMLAEMSGNLAMT
SLMPVINQSIHLINENYSNRQMKSNSLQAHRNILMAIKQRHPVAAYDSMLAHIISVRQVVLSEWFDKDMTLHGLNDHK

Sequences:

>Translated_238_residues
MAKPLVEKASERLLELILERGYEVGDKLPNEYELAQDLEVGRSTVREAVRSLATRNILEVRQGSGTYISSKKGVSEDPLG
FSLVRDRVKLTTDLFEVRYLLEPRIAERVAQFASDEDVAKLEEIVLAIEEAVAAGDTKHLELDVKFHCMLAEMSGNLAMT
SLMPVINQSIHLINENYSNRQMKSNSLQAHRNILMAIKQRHPVAAYDSMLAHIISVRQVVLSEWFDKDMTLHGLNDHK
>Mature_237_residues
AKPLVEKASERLLELILERGYEVGDKLPNEYELAQDLEVGRSTVREAVRSLATRNILEVRQGSGTYISSKKGVSEDPLGF
SLVRDRVKLTTDLFEVRYLLEPRIAERVAQFASDEDVAKLEEIVLAIEEAVAAGDTKHLELDVKFHCMLAEMSGNLAMTS
LMPVINQSIHLINENYSNRQMKSNSLQAHRNILMAIKQRHPVAAYDSMLAHIISVRQVVLSEWFDKDMTLHGLNDHK

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790780, Length=218, Percent_Identity=30.2752293577982, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790032, Length=243, Percent_Identity=28.3950617283951, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=31.7596566523605, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082208, Length=231, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789353, Length=225, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=26.4150943396226, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26897; Mature: 26766

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPLVEKASERLLELILERGYEVGDKLPNEYELAQDLEVGRSTVREAVRSLATRNILEV
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQGSGTYISSKKGVSEDPLGFSLVRDRVKLTTDLFEVRYLLEPRIAERVAQFASDEDVAK
HCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHH
LEEIVLAIEEAVAAGDTKHLELDVKFHCMLAEMSGNLAMTSLMPVINQSIHLINENYSNR
HHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCHH
QMKSNSLQAHRNILMAIKQRHPVAAYDSMLAHIISVRQVVLSEWFDKDMTLHGLNDHK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure 
AKPLVEKASERLLELILERGYEVGDKLPNEYELAQDLEVGRSTVREAVRSLATRNILEV
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQGSGTYISSKKGVSEDPLGFSLVRDRVKLTTDLFEVRYLLEPRIAERVAQFASDEDVAK
HCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHH
LEEIVLAIEEAVAAGDTKHLELDVKFHCMLAEMSGNLAMTSLMPVINQSIHLINENYSNR
HHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCHH
QMKSNSLQAHRNILMAIKQRHPVAAYDSMLAHIISVRQVVLSEWFDKDMTLHGLNDHK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA