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The map label for this gene is edd [H]

Identifier: 225686547

GI number: 225686547

Start: 739155

End: 740996

Strand: Direct

Name: edd [H]

Synonym: BMEA_B0758

Alternate gene names: 225686547

Gene position: 739155-740996 (Clockwise)

Preceding gene: 225686546

Following gene: 225686549

Centisome position: 62.35

GC content: 61.02

Gene sequence:

>1842_bases
TTGGCACAGGTGATACCCATGTCCACCGAGACGGCACATAAACGCATTCAGGAAATCACCGAGCGTATCCGTGAGCGCTC
CAAACCTACCCGCGAAGCCTATCTGGACCGGGTGCGGGAGGCTGCCTCCAACAAGCCGAAGCGTTCCTTTCTGGGATGCG
CGAATCTCGCTCATGGTTTTGCGGCCTGCGGCCCGCATGACAAGGCCGCGCTGACCGCCGATGTCGTACCGAACCTCGGC
ATCATCACCGCCTATAATGATATGCTTTCGGCGCACCAGCCTTTTGAAACCTTCCCGCAACTCATTAAGCAGGCAGCGCG
CGAAGCGGGCGGCGTGGCGCAGGTGGCCGGTGGTGTGCCTGCCATGTGCGATGGCGTCACGCAAGGTTTTGCCGGCATGG
AACTCTCGCTCTTTTCGCGCGAAGTCATTGCCATGGCCACGGCCGTTGGCCTCTCGCACGATATGTTCGATGCCGCCGTC
TATCTCGGCGTCTGCGACAAGATTGTGCCGAGACTAATTGTCGGCGCGCTGACCTTCGGCCATCTGCCTCCCGTCTTCAT
TCCAGCCGGCCCGATGACCAGCGGACTGCCGAATGATGAAAAGGCGAAAACCCGCCAGCTTTATGCCGAAGGCAAGGTGG
GCCGGGCGGAACTGCTGGAATCGGAATCGAAATCTTATCACGGCCCTGGCACCTGCACCTTCTACGGCACCGCCAACTCC
AACCAGATGTTGATGGAGATCATGGGCCTGCATCTTCCCGGCGCATCATTCATCAATCCGGGAACGCCGCTGCGCGATGC
GCTGACACGCGAAGCTGCCAAGCGCGCGCTCGCCATCACCGCGCTCGGCAATGAATATACGCCGGTTGGCGAGATGATTG
ATGAGCGATCCATCGTCAACGGCGTGGTCGGGCTGAACGCCACTGGCGGCTCCACCAACCACACAATCCACCTGATCGCC
ATGGCCGCCGCGGCTGGCATCAAGCTGACATGGCACGATATTTCGCAGATATCAGACGTGGTGCCGCTTCTGGCCCGCGT
CTATCCGAACGGACTTGCGGATGTGAACCATTTCCACGCCGCAGGCGGCATGGGCTTCCTCATCCGCGAACTCCTCGACG
GCGGCCTGCTGCATGAAGATGTGCGCACCGTCTGGGGGGAAGGCCTGCGCCCCTATGCCATTGAGCCGAAGCTCGGCCCC
GACGGCAACGTCGTGCGCGAAGCCGCGCCGGAAAAAAGCGGCGACGACAAGGTTCTGGCCAAGATTGCCGCACCATTCCA
GCCAACCGGCGGCATCAAGGTGCTGAGCGGCAATATTGGCAATGCGATCATCAAGGTTTCCGCCGTAAAGCCGGAACGTC
ATGTGATCGAAGCACCCGCGAAAGTCTTCAACGATCAGGCGGAATTGCAGGCCGCTTTCAAGGCGGGCGACCTCACCGGC
GATTTTATTGCCGTGGTGCGTTATCAGGGGCCAAAAGCCAATGGCATGCCCGAACTGCACAAGCTGATGACCGTTCTGGG
CATTCTTCAGGATCGCGGCCAGCGCGTGGCGCTCGTCACCGATGGGCGTCTGTCCGGTGCATCCGGCAAGGTTCCCTCTG
CCATCCACGTCACGCCGGAAGCACTTGATGGCGGCATGGTCGGCAAAATCCGCACCGGCGATATTATCCGCCTCGATGCA
ATCAACGGCACGCTGGAAGTCTTGCTCAATCAGGCCGTGCTCGACAGCCGTATCGAGGAGCGGCCCGATCTTTCCGGCAA
CGAATATGGCATGGGCCGCGAGCTGTTCCGTGCCTTCCGCCAGATTGCCGGGCGGGCGGATGAAGGCGCCTCGGTGTTCT
GA

Upstream 100 bases:

>100_bases
CAGGCGACGATGAGCGGGAAATGCCCGTGCGGGCTGTCTTCCATCATGCCCGCGCACCGATCCAGCTTTACTGGGCAAGT
TAAATTCGATTGAAGCCAGA

Downstream 100 bases:

>100_bases
AACAGCGCGAATAAAATGAAGGCAAAACAGCAATTTCGGCTGTTTTGCCTTTCAAACCATCAAAGCCGGAATAAAGCGCG
GCTCGTCCGCATCAGAAAAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MAQVIPMSTETAHKRIQEITERIRERSKPTREAYLDRVREAASNKPKRSFLGCANLAHGFAACGPHDKAALTADVVPNLG
IITAYNDMLSAHQPFETFPQLIKQAAREAGGVAQVAGGVPAMCDGVTQGFAGMELSLFSREVIAMATAVGLSHDMFDAAV
YLGVCDKIVPRLIVGALTFGHLPPVFIPAGPMTSGLPNDEKAKTRQLYAEGKVGRAELLESESKSYHGPGTCTFYGTANS
NQMLMEIMGLHLPGASFINPGTPLRDALTREAAKRALAITALGNEYTPVGEMIDERSIVNGVVGLNATGGSTNHTIHLIA
MAAAAGIKLTWHDISQISDVVPLLARVYPNGLADVNHFHAAGGMGFLIRELLDGGLLHEDVRTVWGEGLRPYAIEPKLGP
DGNVVREAAPEKSGDDKVLAKIAAPFQPTGGIKVLSGNIGNAIIKVSAVKPERHVIEAPAKVFNDQAELQAAFKAGDLTG
DFIAVVRYQGPKANGMPELHKLMTVLGILQDRGQRVALVTDGRLSGASGKVPSAIHVTPEALDGGMVGKIRTGDIIRLDA
INGTLEVLLNQAVLDSRIEERPDLSGNEYGMGRELFRAFRQIAGRADEGASVF

Sequences:

>Translated_613_residues
MAQVIPMSTETAHKRIQEITERIRERSKPTREAYLDRVREAASNKPKRSFLGCANLAHGFAACGPHDKAALTADVVPNLG
IITAYNDMLSAHQPFETFPQLIKQAAREAGGVAQVAGGVPAMCDGVTQGFAGMELSLFSREVIAMATAVGLSHDMFDAAV
YLGVCDKIVPRLIVGALTFGHLPPVFIPAGPMTSGLPNDEKAKTRQLYAEGKVGRAELLESESKSYHGPGTCTFYGTANS
NQMLMEIMGLHLPGASFINPGTPLRDALTREAAKRALAITALGNEYTPVGEMIDERSIVNGVVGLNATGGSTNHTIHLIA
MAAAAGIKLTWHDISQISDVVPLLARVYPNGLADVNHFHAAGGMGFLIRELLDGGLLHEDVRTVWGEGLRPYAIEPKLGP
DGNVVREAAPEKSGDDKVLAKIAAPFQPTGGIKVLSGNIGNAIIKVSAVKPERHVIEAPAKVFNDQAELQAAFKAGDLTG
DFIAVVRYQGPKANGMPELHKLMTVLGILQDRGQRVALVTDGRLSGASGKVPSAIHVTPEALDGGMVGKIRTGDIIRLDA
INGTLEVLLNQAVLDSRIEERPDLSGNEYGMGRELFRAFRQIAGRADEGASVF
>Mature_612_residues
AQVIPMSTETAHKRIQEITERIRERSKPTREAYLDRVREAASNKPKRSFLGCANLAHGFAACGPHDKAALTADVVPNLGI
ITAYNDMLSAHQPFETFPQLIKQAAREAGGVAQVAGGVPAMCDGVTQGFAGMELSLFSREVIAMATAVGLSHDMFDAAVY
LGVCDKIVPRLIVGALTFGHLPPVFIPAGPMTSGLPNDEKAKTRQLYAEGKVGRAELLESESKSYHGPGTCTFYGTANSN
QMLMEIMGLHLPGASFINPGTPLRDALTREAAKRALAITALGNEYTPVGEMIDERSIVNGVVGLNATGGSTNHTIHLIAM
AAAAGIKLTWHDISQISDVVPLLARVYPNGLADVNHFHAAGGMGFLIRELLDGGLLHEDVRTVWGEGLRPYAIEPKLGPD
GNVVREAAPEKSGDDKVLAKIAAPFQPTGGIKVLSGNIGNAIIKVSAVKPERHVIEAPAKVFNDQAELQAAFKAGDLTGD
FIAVVRYQGPKANGMPELHKLMTVLGILQDRGQRVALVTDGRLSGASGKVPSAIHVTPEALDGGMVGKIRTGDIIRLDAI
NGTLEVLLNQAVLDSRIEERPDLSGNEYGMGRELFRAFRQIAGRADEGASVF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=599, Percent_Identity=61.2687813021703, Blast_Score=749, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=579, Percent_Identity=29.1882556131261, Blast_Score=190, Evalue=3e-49,
Organism=Escherichia coli, GI2367371, Length=461, Percent_Identity=30.3687635574837, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786464, Length=460, Percent_Identity=29.7826086956522, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=491, Percent_Identity=27.9022403258656, Blast_Score=165, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65166; Mature: 65034

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVIPMSTETAHKRIQEITERIRERSKPTREAYLDRVREAASNKPKRSFLGCANLAHGF
CCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AACGPHDKAALTADVVPNLGIITAYNDMLSAHQPFETFPQLIKQAAREAGGVAQVAGGVP
HHCCCCCCCEEEHHHCCCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCC
AMCDGVTQGFAGMELSLFSREVIAMATAVGLSHDMFDAAVYLGVCDKIVPRLIVGALTFG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HLPPVFIPAGPMTSGLPNDEKAKTRQLYAEGKVGRAELLESESKSYHGPGTCTFYGTANS
CCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCC
NQMLMEIMGLHLPGASFINPGTPLRDALTREAAKRALAITALGNEYTPVGEMIDERSIVN
CHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHH
GVVGLNATGGSTNHTIHLIAMAAAAGIKLTWHDISQISDVVPLLARVYPNGLADVNHFHA
HHEEECCCCCCCCCEEEEEEEHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AGGMGFLIRELLDGGLLHEDVRTVWGEGLRPYAIEPKLGPDGNVVREAAPEKSGDDKVLA
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHCCCCCCCCHHHHH
KIAAPFQPTGGIKVLSGNIGNAIIKVSAVKPERHVIEAPAKVFNDQAELQAAFKAGDLTG
HHHCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
DFIAVVRYQGPKANGMPELHKLMTVLGILQDRGQRVALVTDGRLSGASGKVPSAIHVTPE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHH
ALDGGMVGKIRTGDIIRLDAINGTLEVLLNQAVLDSRIEERPDLSGNEYGMGRELFRAFR
HHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
QIAGRADEGASVF
HHHCCCCCCCCCC
>Mature Secondary Structure 
AQVIPMSTETAHKRIQEITERIRERSKPTREAYLDRVREAASNKPKRSFLGCANLAHGF
CCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AACGPHDKAALTADVVPNLGIITAYNDMLSAHQPFETFPQLIKQAAREAGGVAQVAGGVP
HHCCCCCCCEEEHHHCCCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCC
AMCDGVTQGFAGMELSLFSREVIAMATAVGLSHDMFDAAVYLGVCDKIVPRLIVGALTFG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HLPPVFIPAGPMTSGLPNDEKAKTRQLYAEGKVGRAELLESESKSYHGPGTCTFYGTANS
CCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCC
NQMLMEIMGLHLPGASFINPGTPLRDALTREAAKRALAITALGNEYTPVGEMIDERSIVN
CHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHH
GVVGLNATGGSTNHTIHLIAMAAAAGIKLTWHDISQISDVVPLLARVYPNGLADVNHFHA
HHEEECCCCCCCCCEEEEEEEHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AGGMGFLIRELLDGGLLHEDVRTVWGEGLRPYAIEPKLGPDGNVVREAAPEKSGDDKVLA
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHCCCCCCCCHHHHH
KIAAPFQPTGGIKVLSGNIGNAIIKVSAVKPERHVIEAPAKVFNDQAELQAAFKAGDLTG
HHHCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
DFIAVVRYQGPKANGMPELHKLMTVLGILQDRGQRVALVTDGRLSGASGKVPSAIHVTPE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHH
ALDGGMVGKIRTGDIIRLDAINGTLEVLLNQAVLDSRIEERPDLSGNEYGMGRELFRAFR
HHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
QIAGRADEGASVF
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]