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The map label for this gene is pgl [H]

Identifier: 225686546

GI number: 225686546

Start: 738439

End: 739137

Strand: Direct

Name: pgl [H]

Synonym: BMEA_B0757

Alternate gene names: 225686546

Gene position: 738439-739137 (Clockwise)

Preceding gene: 225686545

Following gene: 225686547

Centisome position: 62.29

GC content: 61.09

Gene sequence:

>699_bases
ATGAGCATCGAACGGCACGATTTCATCAGCGCAACGGAACTGGCGCAGTCGCTTTCCGAGGCGATTGCAAACAAGCTGGC
AACCGCGATCGCTGAACGGGGACAGGCCGTGCTGGCCGTCTCTGGCGGCACCACGCCGCTCAAGCTGTTTGAAGTGCTGT
CGCGCAAGATGATCGACTGGAACCTTGTCACGATTACCCTCGTGGACGAGCGTTTTGTGCCGGTGGAGAACGAACGCTCC
AACGAAAAGCTGGTGCGCGACCATCTTTTGCGCGACCATGCGGGCGTAGCCAGATTTGTCGGCCTCTACAATCCGGCGGC
GACGGCCGAAACAGCAGCACTTGCCGCCGCCAGCCGCATTGACGCGCTGCGCCGCCCTTTCGATGTGGTGGTGCTTGGCA
TGGGCAATGACGGTCATACCGCTTCCTTCTTCCCCAATGCCGACCGGCTCGATCAGGCGATCAACCCGGCGACACGCGCG
CTTGTTCTGCCGATCCATGCCGAAGGCGCTGGCGAAAAGCGCCTGACGCTTACCCTGCCGCTGATTGCCGAAGCCGAAAT
GCTGGTGCTGCATATTGAAGGCGCGGCAAAGCAGGCGACACTGGAAAAGGCGCTTGCAGGCGACGATGAGCGGGAAATGC
CCGTGCGGGCTGTCTTCCATCATGCCCGCGCACCGATCCAGCTTTACTGGGCAAGTTAA

Upstream 100 bases:

>100_bases
TTTTTTGCGCCGGATAATGCATAAAAACAAATGGTTAGAGCAGCTTCGGCGATTCTGTTAAAACAGAAACCGCTCTAATT
GTTGTTTGGAAAGGAATGGA

Downstream 100 bases:

>100_bases
ATTCGATTGAAGCCAGATTGGCACAGGTGATACCCATGTCCACCGAGACGGCACATAAACGCATTCAGGAAATCACCGAG
CGTATCCGTGAGCGCTCCAA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSIERHDFISATELAQSLSEAIANKLATAIAERGQAVLAVSGGTTPLKLFEVLSRKMIDWNLVTITLVDERFVPVENERS
NEKLVRDHLLRDHAGVARFVGLYNPAATAETAALAAASRIDALRRPFDVVVLGMGNDGHTASFFPNADRLDQAINPATRA
LVLPIHAEGAGEKRLTLTLPLIAEAEMLVLHIEGAAKQATLEKALAGDDEREMPVRAVFHHARAPIQLYWAS

Sequences:

>Translated_232_residues
MSIERHDFISATELAQSLSEAIANKLATAIAERGQAVLAVSGGTTPLKLFEVLSRKMIDWNLVTITLVDERFVPVENERS
NEKLVRDHLLRDHAGVARFVGLYNPAATAETAALAAASRIDALRRPFDVVVLGMGNDGHTASFFPNADRLDQAINPATRA
LVLPIHAEGAGEKRLTLTLPLIAEAEMLVLHIEGAAKQATLEKALAGDDEREMPVRAVFHHARAPIQLYWAS
>Mature_231_residues
SIERHDFISATELAQSLSEAIANKLATAIAERGQAVLAVSGGTTPLKLFEVLSRKMIDWNLVTITLVDERFVPVENERSN
EKLVRDHLLRDHAGVARFVGLYNPAATAETAALAAASRIDALRRPFDVVVLGMGNDGHTASFFPNADRLDQAINPATRAL
VLPIHAEGAGEKRLTLTLPLIAEAEMLVLHIEGAAKQATLEKALAGDDEREMPVRAVFHHARAPIQLYWAS

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=240, Percent_Identity=31.25, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI6912586, Length=243, Percent_Identity=29.2181069958848, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321687, Length=216, Percent_Identity=30.0925925925926, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321957, Length=205, Percent_Identity=27.8048780487805, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641119, Length=215, Percent_Identity=29.3023255813954, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900 [H]

Pfam domain/function: NA

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25212; Mature: 25081

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIERHDFISATELAQSLSEAIANKLATAIAERGQAVLAVSGGTTPLKLFEVLSRKMIDW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCC
NLVTITLVDERFVPVENERSNEKLVRDHLLRDHAGVARFVGLYNPAATAETAALAAASRI
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DALRRPFDVVVLGMGNDGHTASFFPNADRLDQAINPATRALVLPIHAEGAGEKRLTLTLP
HHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEC
LIAEAEMLVLHIEGAAKQATLEKALAGDDEREMPVRAVFHHARAPIQLYWAS
CCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
SIERHDFISATELAQSLSEAIANKLATAIAERGQAVLAVSGGTTPLKLFEVLSRKMIDW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCC
NLVTITLVDERFVPVENERSNEKLVRDHLLRDHAGVARFVGLYNPAATAETAALAAASRI
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DALRRPFDVVVLGMGNDGHTASFFPNADRLDQAINPATRALVLPIHAEGAGEKRLTLTLP
HHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEC
LIAEAEMLVLHIEGAAKQATLEKALAGDDEREMPVRAVFHHARAPIQLYWAS
CCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]