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The map label for this gene is proC [H]

Identifier: 225686549

GI number: 225686549

Start: 742308

End: 743123

Strand: Direct

Name: proC [H]

Synonym: BMEA_B0760

Alternate gene names: 225686549

Gene position: 742308-743123 (Clockwise)

Preceding gene: 225686547

Following gene: 225686554

Centisome position: 62.61

GC content: 60.42

Gene sequence:

>816_bases
ATGCAGGATAAGGTAGTTCTGGTCGGTTGCGGCAATATGGGCTTTGCCATGCTGAGAGGCTGGCTCGACAGCGGCATCCT
GAAAGCTGGTGACGTCCATGTGGTGGAACCGGCTGAGGCGCTGCGCGAGCGCGCAGCATTGGCCCATGTACATGTCTATG
CGGATGCGGCGGACCTGCCCGCCGATCTTCAACCACGCATGGTGCTGGTTGCCGTCAAGCCGCAGATGATGGCCAATGTG
CTGCCCGCCTATAAACGCTTCGCACCGGCTTCAACCTTTGTGAGCGTCGCCGCTGGCATTCCGGTCGCGCTGTTTGAAAG
CCATCTGGGCAAAGACGTTGCGGTCATCCGCTGTATGCCGAACACACCCGCCGCCATCGGCAAGGGTATGCTCGTCACCT
TCAAGAACGCCAATGTGAGTGACGCAAATGAAGCCTTTGTCACAAGCCTTCTCAAAACCTCCGGCAAGGTGGCAAGCGTG
GATGAGGAAGGGTTGATGGATGCGGTAACTGCCGTTTCCGGTTCCGGCCCGGCCTATATATTCCACTTCATCGAGGCGCT
GACGGATGCGGGCGTGAACCTTGGCCTGCCGCGCGAAACGGCCGCCCTCCTCGCCATGCAGACAGTGATGGGAGCCGGCG
CGCTGGCAGATGCCAGCACGGACAGCCCGTCAAAACTGCGCGAACAGGTGACAAGCCCGAACGGCACCACAGCAGCGGCA
CTTGACGTGCTGATGGGCGGCGACCGGCTCAAAGAACTCGTGGCTGAAGCCGTTAAAGCCGCACACAAGCGTTCGGTCGA
GCTGGGCAAGAGTTAA

Upstream 100 bases:

>100_bases
TCCATAAAAAGTCATGGAATTACCGCTTGAACATGCTCTATACCCCTTTTCAAACAATGATGGGTTTCAACTCCAGCGAT
CCAAAGGCGGAACGATCAAC

Downstream 100 bases:

>100_bases
GCCGCTAGAACATTTTCGAGCTAAAAGTGCGAAGCGCCTATGCGGGGAAATGCGTAAAAACAAAGAGATAGAGCGGTTTC
AACGATTCCGTTAAAACCGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQDKVVLVGCGNMGFAMLRGWLDSGILKAGDVHVVEPAEALRERAALAHVHVYADAADLPADLQPRMVLVAVKPQMMANV
LPAYKRFAPASTFVSVAAGIPVALFESHLGKDVAVIRCMPNTPAAIGKGMLVTFKNANVSDANEAFVTSLLKTSGKVASV
DEEGLMDAVTAVSGSGPAYIFHFIEALTDAGVNLGLPRETAALLAMQTVMGAGALADASTDSPSKLREQVTSPNGTTAAA
LDVLMGGDRLKELVAEAVKAAHKRSVELGKS

Sequences:

>Translated_271_residues
MQDKVVLVGCGNMGFAMLRGWLDSGILKAGDVHVVEPAEALRERAALAHVHVYADAADLPADLQPRMVLVAVKPQMMANV
LPAYKRFAPASTFVSVAAGIPVALFESHLGKDVAVIRCMPNTPAAIGKGMLVTFKNANVSDANEAFVTSLLKTSGKVASV
DEEGLMDAVTAVSGSGPAYIFHFIEALTDAGVNLGLPRETAALLAMQTVMGAGALADASTDSPSKLREQVTSPNGTTAAA
LDVLMGGDRLKELVAEAVKAAHKRSVELGKS
>Mature_271_residues
MQDKVVLVGCGNMGFAMLRGWLDSGILKAGDVHVVEPAEALRERAALAHVHVYADAADLPADLQPRMVLVAVKPQMMANV
LPAYKRFAPASTFVSVAAGIPVALFESHLGKDVAVIRCMPNTPAAIGKGMLVTFKNANVSDANEAFVTSLLKTSGKVASV
DEEGLMDAVTAVSGSGPAYIFHFIEALTDAGVNLGLPRETAALLAMQTVMGAGALADASTDSPSKLREQVTSPNGTTAAA
LDVLMGGDRLKELVAEAVKAAHKRSVELGKS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=34.4444444444444, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=34.4444444444444, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=34.4444444444444, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI198041662, Length=272, Percent_Identity=30.5147058823529, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786585, Length=274, Percent_Identity=35.7664233576642, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=272, Percent_Identity=33.0882352941176, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=27.0462633451957, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=204, Percent_Identity=32.843137254902, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358587, Length=242, Percent_Identity=40.0826446280992, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=34.1637010676157, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647700, Length=146, Percent_Identity=46.5753424657534, Blast_Score=120, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28134; Mature: 28134

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKVVLVGCGNMGFAMLRGWLDSGILKAGDVHVVEPAEALRERAALAHVHVYADAADLP
CCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHEEEEECCCCCC
ADLQPRMVLVAVKPQMMANVLPAYKRFAPASTFVSVAAGIPVALFESHLGKDVAVIRCMP
CCCCCCEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEECC
NTPAAIGKGMLVTFKNANVSDANEAFVTSLLKTSGKVASVDEEGLMDAVTAVSGSGPAYI
CCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCCHHHH
FHFIEALTDAGVNLGLPRETAALLAMQTVMGAGALADASTDSPSKLREQVTSPNGTTAAA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
LDVLMGGDRLKELVAEAVKAAHKRSVELGKS
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQDKVVLVGCGNMGFAMLRGWLDSGILKAGDVHVVEPAEALRERAALAHVHVYADAADLP
CCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHEEEEECCCCCC
ADLQPRMVLVAVKPQMMANVLPAYKRFAPASTFVSVAAGIPVALFESHLGKDVAVIRCMP
CCCCCCEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEECC
NTPAAIGKGMLVTFKNANVSDANEAFVTSLLKTSGKVASVDEEGLMDAVTAVSGSGPAYI
CCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCCHHHH
FHFIEALTDAGVNLGLPRETAALLAMQTVMGAGALADASTDSPSKLREQVTSPNGTTAAA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
LDVLMGGDRLKELVAEAVKAAHKRSVELGKS
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]