Click here to switch to the map view.

The map label for this gene is adhB [H]

Identifier: 225686213

GI number: 225686213

Start: 364584

End: 365711

Strand: Direct

Name: adhB [H]

Synonym: BMEA_B0380

Alternate gene names: 225686213

Gene position: 364584-365711 (Clockwise)

Preceding gene: 225686212

Following gene: 225686221

Centisome position: 30.75

GC content: 56.29

Gene sequence:

>1128_bases
ATGAAATTCAAAGCCGCTGTTCTTGACCGCCATGGTGTCGAACGCCCCTACAACCAGACCAAACCGCTTGTCATTCGTGA
AGTCGAGCTTCGCGAACCCAAAGCCGATGAAGTTCTCGTCAAACTCGCCGCTTCGGGCCTGTGCCATTCCGACCTTTCGG
TTATCAATGGCGATCGTTCGCGCCAGATCCCCATGGTTCTGGGGCATGAAGCTGCCGGTGTAGTGGAAAAGATTGGTGAG
GGTGTCACCGATCTGGTTCCCGGCGACCATGTTGTTTGCGTTTTCGTGCCCAATTGCGGCCATTGCCAACCCTGCGCCGA
GGGGCGGCCCGCCCTGTGCGAGCCGGGCGCTGCGGCAAACGGCAAGGGCGAAATGCTTTCCGGCGGGCTTCGTCTCTTTT
GTGATGATGGCGATGTCTATCATCATTGCGGCGTTTCAGCTTATGCGGAATATGCGGTGATGTCGCGTTATTCGATAATC
CGTATCGAAAAGGATATTCCGCTTCATATTGCAGCCCTGATGGGCTGTGCGGTGCTGACCGGGACCGGCTCGATTTTCAA
TACCGGTCTGGTGAAGCCTGGCAGCAGGGTTGCCATCGCCGGTCTTGGCGGTGTCGGCCTTGCGGCGGTGATGGGCGCCG
TGGCCGCAGGCGCGACAGAGATTATCGCCCTCGACATGTTCGATGACAAGCTGGCGCTTGCCGAACAGCTTGGGGCCACC
AAAACCTTCAATGTCCAGTCTGAAGGCGTTGTCGAGGCGGTCAAGGAATATACGAAGGGCGGCGTCGATGCGGCTTTTGA
ATATGCCGGTTCGGGTGCGGCACTTGCCATGTGCTATGCCCTGACGAAGCGCGGCGGCGAAGTGGTCACGGCTGGCCTTC
CGAACCCGAAGAACATGCTTTCCATTCCTGCTGTCAGCCTTGTGGCGGAAGAAAAATCCATTCGCGGCAGCTATCTTGGT
TCCGGTGTGCCGACGCGGGATATTCCTCTGTTTCTTGATCTTTATCGCAAAGGCAAATTGCCTGTCGAAAAGCTTCTCAC
CCATCGTATCAAGCTTGAAGAAATTAACGAGGGTTTTGAGCGCCTTGCTGCTGGAAAAGCAATCCGGCAGGTCGTTGAAT
TCAATTGA

Upstream 100 bases:

>100_bases
ACGCCGCCGCCATATCGGAAATCCGGTTGCCGCAGTAACAGTCGTCACCGAGGTTGGGCAGTCTGCCCAGCCTCCCTGAA
GCCTTAAAGGAACCAGATCG

Downstream 100 bases:

>100_bases
TGGCTGGTCGATAATAGCTGGTTTTGGGCTTAGAGCGCGTTCCGGCATCGCACAAAGCTGCCTCTTCGGGCAGCTTTGTC
GTTTTTCGGCATCCTTTTTC

Product: alcohol dehydrogenase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKFKAAVLDRHGVERPYNQTKPLVIREVELREPKADEVLVKLAASGLCHSDLSVINGDRSRQIPMVLGHEAAGVVEKIGE
GVTDLVPGDHVVCVFVPNCGHCQPCAEGRPALCEPGAAANGKGEMLSGGLRLFCDDGDVYHHCGVSAYAEYAVMSRYSII
RIEKDIPLHIAALMGCAVLTGTGSIFNTGLVKPGSRVAIAGLGGVGLAAVMGAVAAGATEIIALDMFDDKLALAEQLGAT
KTFNVQSEGVVEAVKEYTKGGVDAAFEYAGSGAALAMCYALTKRGGEVVTAGLPNPKNMLSIPAVSLVAEEKSIRGSYLG
SGVPTRDIPLFLDLYRKGKLPVEKLLTHRIKLEEINEGFERLAAGKAIRQVVEFN

Sequences:

>Translated_375_residues
MKFKAAVLDRHGVERPYNQTKPLVIREVELREPKADEVLVKLAASGLCHSDLSVINGDRSRQIPMVLGHEAAGVVEKIGE
GVTDLVPGDHVVCVFVPNCGHCQPCAEGRPALCEPGAAANGKGEMLSGGLRLFCDDGDVYHHCGVSAYAEYAVMSRYSII
RIEKDIPLHIAALMGCAVLTGTGSIFNTGLVKPGSRVAIAGLGGVGLAAVMGAVAAGATEIIALDMFDDKLALAEQLGAT
KTFNVQSEGVVEAVKEYTKGGVDAAFEYAGSGAALAMCYALTKRGGEVVTAGLPNPKNMLSIPAVSLVAEEKSIRGSYLG
SGVPTRDIPLFLDLYRKGKLPVEKLLTHRIKLEEINEGFERLAAGKAIRQVVEFN
>Mature_375_residues
MKFKAAVLDRHGVERPYNQTKPLVIREVELREPKADEVLVKLAASGLCHSDLSVINGDRSRQIPMVLGHEAAGVVEKIGE
GVTDLVPGDHVVCVFVPNCGHCQPCAEGRPALCEPGAAANGKGEMLSGGLRLFCDDGDVYHHCGVSAYAEYAVMSRYSII
RIEKDIPLHIAALMGCAVLTGTGSIFNTGLVKPGSRVAIAGLGGVGLAAVMGAVAAGATEIIALDMFDDKLALAEQLGAT
KTFNVQSEGVVEAVKEYTKGGVDAAFEYAGSGAALAMCYALTKRGGEVVTAGLPNPKNMLSIPAVSLVAEEKSIRGSYLG
SGVPTRDIPLFLDLYRKGKLPVEKLLTHRIKLEEINEGFERLAAGKAIRQVVEFN

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=380, Percent_Identity=38.9473684210526, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI4501933, Length=380, Percent_Identity=38.4210526315789, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI4501929, Length=380, Percent_Identity=37.6315789473684, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=37.5342465753425, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI71743840, Length=380, Percent_Identity=35, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI262073058, Length=380, Percent_Identity=35, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=35.5191256830601, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI156523966, Length=380, Percent_Identity=36.0526315789474, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4501939, Length=374, Percent_Identity=36.096256684492, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI156627571, Length=367, Percent_Identity=25.0681198910082, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=35.1851851851852, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=28.9972899728997, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87081918, Length=375, Percent_Identity=32, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788407, Length=376, Percent_Identity=28.7234042553192, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790045, Length=368, Percent_Identity=25.5434782608696, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=26.9121813031161, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788075, Length=346, Percent_Identity=25.4335260115607, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=26.1494252873563, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786825, Length=372, Percent_Identity=27.1505376344086, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790718, Length=292, Percent_Identity=26.7123287671233, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786518, Length=358, Percent_Identity=25.9776536312849, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=23.9884393063584, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082401, Length=358, Percent_Identity=26.536312849162, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=33.879781420765, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=33.695652173913, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17565904, Length=357, Percent_Identity=31.6526610644258, Blast_Score=203, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17562584, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=358, Percent_Identity=26.8156424581006, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=366, Percent_Identity=25.6830601092896, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=361, Percent_Identity=27.9778393351801, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=25.4237288135593, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=35.5978260869565, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323729, Length=364, Percent_Identity=28.2967032967033, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=363, Percent_Identity=29.2011019283747, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=356, Percent_Identity=29.4943820224719, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=364, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=356, Percent_Identity=29.2134831460674, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=29.3956043956044, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=366, Percent_Identity=25.4098360655738, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=380, Percent_Identity=25, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=35.7142857142857, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17737897, Length=384, Percent_Identity=29.4270833333333, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137530, Length=381, Percent_Identity=28.0839895013123, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39568; Mature: 39568

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKAAVLDRHGVERPYNQTKPLVIREVELREPKADEVLVKLAASGLCHSDLSVINGDRS
CCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCC
RQIPMVLGHEAAGVVEKIGEGVTDLVPGDHVVCVFVPNCGHCQPCAEGRPALCEPGAAAN
CCCCEEECCCHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GKGEMLSGGLRLFCDDGDVYHHCGVSAYAEYAVMSRYSIIRIEKDIPLHIAALMGCAVLT
CCCCEECCCEEEEECCCCEEECCCHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHC
GTGSIFNTGLVKPGSRVAIAGLGGVGLAAVMGAVAAGATEIIALDMFDDKLALAEQLGAT
CCCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCC
KTFNVQSEGVVEAVKEYTKGGVDAAFEYAGSGAALAMCYALTKRGGEVVTAGLPNPKNML
EEECCCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHE
SIPAVSLVAEEKSIRGSYLGSGVPTRDIPLFLDLYRKGKLPVEKLLTHRIKLEEINEGFE
ECCHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RLAAGKAIRQVVEFN
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFKAAVLDRHGVERPYNQTKPLVIREVELREPKADEVLVKLAASGLCHSDLSVINGDRS
CCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCC
RQIPMVLGHEAAGVVEKIGEGVTDLVPGDHVVCVFVPNCGHCQPCAEGRPALCEPGAAAN
CCCCEEECCCHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GKGEMLSGGLRLFCDDGDVYHHCGVSAYAEYAVMSRYSIIRIEKDIPLHIAALMGCAVLT
CCCCEECCCEEEEECCCCEEECCCHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHC
GTGSIFNTGLVKPGSRVAIAGLGGVGLAAVMGAVAAGATEIIALDMFDDKLALAEQLGAT
CCCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCC
KTFNVQSEGVVEAVKEYTKGGVDAAFEYAGSGAALAMCYALTKRGGEVVTAGLPNPKNML
EEECCCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHE
SIPAVSLVAEEKSIRGSYLGSGVPTRDIPLFLDLYRKGKLPVEKLLTHRIKLEEINEGFE
ECCHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RLAAGKAIRQVVEFN
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]