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The map label for this gene is cysK [H]

Identifier: 225853403

GI number: 225853403

Start: 1915052

End: 1916062

Strand: Direct

Name: cysK [H]

Synonym: BMEA_A2024

Alternate gene names: 225853403

Gene position: 1915052-1916062 (Clockwise)

Preceding gene: 225853399

Following gene: 225853408

Centisome position: 90.09

GC content: 57.86

Gene sequence:

>1011_bases
TTGCGCGACAGCAACGGAGAATATGCCATGAACAAGCCCCTTGGCTCCAAAGACGCCGAAGCCGCAGGTCGCGGACGCAT
TTATGATTCCATTCTCGATACGATCGGCAATACGCCGCTTGTGCGTATCGACAAGTTTGCCAGGGAAAACGGTGTGAAGG
CCAATCTTCTGGTAAAGCTTGAATTCTTCAATCCGCTGGCAAGCGTGAAGGATCGTATCGGGCTTGCCATGATCGAGGCT
TTGGAAAAGCAGGGCAAGGCTGTCCCCGGCAAGACCGTTTTCGTGGAGCCGACCTCCGGCAATACCGGCATCGCGCTGGC
CTTTGCCGCAGCCGCCAAAGGCTATCGCCTCATTCTCACCATGCCGGAAACCATGTCCATGGAGCGCCGCAAGCTCCTGA
GGCTGCTTGGCGCGGAACTGGTGCTGACCGAAGGCGCGAAAGGCATGAAAGGTGCGATTGCGGAAGCCGAAGCCATTGCC
GAAGGCAACCCCAATGCCATCATCCCGCAACAGTTTGAAAACCCCGCCAACCCGGAAATCCATCGCCTCACGACGGCCGA
GGAAATCTGGAACGATACCAATGGCGAAGCTGATATCCTGATCTCCGGTATCGGCACCGGCGGCACGATCACAGGCGTCG
GTCAGGTCATCAAGGCGCGCAAGCCATCCTTCAAGGTCGTCGCTGTCGAACCGAAGGACTCACCTGTTCTTTCCGGCGGC
GCGCCCGGCCCGCACAAGATTCAAGGGCTTGGTGCGGGCTTTGCACCAAAGACGCTTGATACCGGCATTTATGACGAAAT
CGTGCAGATTTCCAACGAAGATGCTTTCACCAATGCCCGTCTGGTTGCACGGCTTGAGGGCATTCCCGTTGGCATCTCGT
CGGGCGCTGCTCTTGCGGCTGCGATCGAAGTCGGCAAGCGCTCGGAAAATGCAGGCAAGAATATCGTGGTGGTGATCCCG
TCCTTTGCCGAACGGTACCTCTCGACCGCGCTGTTCGAGGGGCTGGAATAA

Upstream 100 bases:

>100_bases
ATTTCCTCCCAATTTTTATCTCCTTAAAGAATTTAATTCTAAATTTTATAGAAGTCACGCACCACGACAGCTATGCCTTT
GCGTCTTTTCCTCTTAAACT

Downstream 100 bases:

>100_bases
GGCGGGCCTCAAGGCTTAGAGCGGGCTCCGGCGAATTCGTTTTAACCGGAGCCCTCTAAAACATACAGATTGAAACGCGT
TTTAACGTCCGCCAGTGCGC

Product: cysteine synthase A

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MRDSNGEYAMNKPLGSKDAEAAGRGRIYDSILDTIGNTPLVRIDKFARENGVKANLLVKLEFFNPLASVKDRIGLAMIEA
LEKQGKAVPGKTVFVEPTSGNTGIALAFAAAAKGYRLILTMPETMSMERRKLLRLLGAELVLTEGAKGMKGAIAEAEAIA
EGNPNAIIPQQFENPANPEIHRLTTAEEIWNDTNGEADILISGIGTGGTITGVGQVIKARKPSFKVVAVEPKDSPVLSGG
APGPHKIQGLGAGFAPKTLDTGIYDEIVQISNEDAFTNARLVARLEGIPVGISSGAALAAAIEVGKRSENAGKNIVVVIP
SFAERYLSTALFEGLE

Sequences:

>Translated_336_residues
MRDSNGEYAMNKPLGSKDAEAAGRGRIYDSILDTIGNTPLVRIDKFARENGVKANLLVKLEFFNPLASVKDRIGLAMIEA
LEKQGKAVPGKTVFVEPTSGNTGIALAFAAAAKGYRLILTMPETMSMERRKLLRLLGAELVLTEGAKGMKGAIAEAEAIA
EGNPNAIIPQQFENPANPEIHRLTTAEEIWNDTNGEADILISGIGTGGTITGVGQVIKARKPSFKVVAVEPKDSPVLSGG
APGPHKIQGLGAGFAPKTLDTGIYDEIVQISNEDAFTNARLVARLEGIPVGISSGAALAAAIEVGKRSENAGKNIVVVIP
SFAERYLSTALFEGLE
>Mature_336_residues
MRDSNGEYAMNKPLGSKDAEAAGRGRIYDSILDTIGNTPLVRIDKFARENGVKANLLVKLEFFNPLASVKDRIGLAMIEA
LEKQGKAVPGKTVFVEPTSGNTGIALAFAAAAKGYRLILTMPETMSMERRKLLRLLGAELVLTEGAKGMKGAIAEAEAIA
EGNPNAIIPQQFENPANPEIHRLTTAEEIWNDTNGEADILISGIGTGGTITGVGQVIKARKPSFKVVAVEPKDSPVLSGG
APGPHKIQGLGAGFAPKTLDTGIYDEIVQISNEDAFTNARLVARLEGIPVGISSGAALAAAIEVGKRSENAGKNIVVVIP
SFAERYLSTALFEGLE

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=39.4904458598726, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=39.4904458598726, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=39.4904458598726, Blast_Score=225, Evalue=6e-59,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=55.7993730407524, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=40.2640264026403, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=50.1650165016502, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI115535073, Length=311, Percent_Identity=52.411575562701, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=49.6666666666667, Blast_Score=293, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=50.1694915254237, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17561720, Length=303, Percent_Identity=48.1848184818482, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=48.1132075471698, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=40.0621118012422, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=39.2523364485981, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17561716, Length=121, Percent_Identity=46.2809917355372, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=34.3949044585987, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=33.8323353293413, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=37.7777777777778, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=37.7777777777778, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35388; Mature: 35388

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSNGEYAMNKPLGSKDAEAAGRGRIYDSILDTIGNTPLVRIDKFARENGVKANLLVKL
CCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHCCCEEEEEEEE
EFFNPLASVKDRIGLAMIEALEKQGKAVPGKTVFVEPTSGNTGIALAFAAAAKGYRLILT
ECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEE
MPETMSMERRKLLRLLGAELVLTEGAKGMKGAIAEAEAIAEGNPNAIIPQQFENPANPEI
CCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCEECCHHCCCCCCCCE
HRLTTAEEIWNDTNGEADILISGIGTGGTITGVGQVIKARKPSFKVVAVEPKDSPVLSGG
EEEECHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEECCC
APGPHKIQGLGAGFAPKTLDTGIYDEIVQISNEDAFTNARLVARLEGIPVGISSGAALAA
CCCCCEEEECCCCCCCCHHCCCHHHHHHHHCCCCCHHHHEEEEEECCCCEECCCCCHHHH
AIEVGKRSENAGKNIVVVIPSFAERYLSTALFEGLE
HHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDSNGEYAMNKPLGSKDAEAAGRGRIYDSILDTIGNTPLVRIDKFARENGVKANLLVKL
CCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHCCCEEEEEEEE
EFFNPLASVKDRIGLAMIEALEKQGKAVPGKTVFVEPTSGNTGIALAFAAAAKGYRLILT
ECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEE
MPETMSMERRKLLRLLGAELVLTEGAKGMKGAIAEAEAIAEGNPNAIIPQQFENPANPEI
CCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCEECCHHCCCCCCCCE
HRLTTAEEIWNDTNGEADILISGIGTGGTITGVGQVIKARKPSFKVVAVEPKDSPVLSGG
EEEECHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEECCC
APGPHKIQGLGAGFAPKTLDTGIYDEIVQISNEDAFTNARLVARLEGIPVGISSGAALAA
CCCCCEEEECCCCCCCCHHCCCHHHHHHHHCCCCCHHHHEEEEEECCCCEECCCCCHHHH
AIEVGKRSENAGKNIVVVIPSFAERYLSTALFEGLE
HHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]