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The map label for this gene is mmsB [H]

Identifier: 225852805

GI number: 225852805

Start: 1293997

End: 1294887

Strand: Direct

Name: mmsB [H]

Synonym: BMEA_A1362

Alternate gene names: 225852805

Gene position: 1293997-1294887 (Clockwise)

Preceding gene: 225852804

Following gene: 225852808

Centisome position: 60.87

GC content: 60.38

Gene sequence:

>891_bases
ATGGCCACAATCGCATTTATCGGCCTCGGCAATATGGGAGGCCCAATGGCCGCCAATCTGGTCAAGGCAGGTCATACGGT
GCGCGGCTTCGATCTTTTGCCGCAGCATCTGGAAGAGGCAAAGGCCAACGGCCTTGAAATCGCGGCAAGTGCTGCGGAAG
CAGTCTCCGATGTGGACGCGGTGATCACCATGTTGCCCGCAGGCAAACATGTTATCTCGGTTTATGAAAACATTGCGCCT
AAGGCCCGCAAAGATTCGCTTTTTGTCGATTGCTCAACCATTGACGTCGATTCGGCCCGCAAGGCACATGAACTGGCAGC
CACACACGGACATCTTTCCATCGACGCGCCGGTTTCCGGCGGCACCGGCGGCGCGGCGGCAGGCACCCTCACCGTCATGG
CGGGCGGAAGCGAGGAGGCTTTCAAGCGCGGCGAGCCAATCCTTCAGCCCATGGCCGGAAAGATCGTCCATTGTGGTGGC
GACGGCGCCGGGCAGGCCGCAAAGATCTGCAACAACATGATCCTCGGCATCTCGATGATCGGCGTCAGCGAAGCCTTCGT
ACTGGCGGAAAAGCTGGGCCTTTCCCATCAGGCGCTGTTCGACGTCGCCTCCACGTCCTCCGGCCAGTGCTGGTCTCTCA
CCACTTACTGCCCGGTTCCGGGCCCGGTCCCTGCCTCGCCTGCGAACAATGACTACAAGCCGGGCTTTGCGGCGGCACTT
ATGCTGAAAGACCTGAAACTATCGCAGGAAGCTGCCAAAAGTGCAGGCGCGGAAACACCTCTTGGCGCACATGCGCGCGA
ACTCTACAGCCGTTTCGACGACGAAGGCCATGGCGGCGAGGATTTTTCCGGCATCATCAATTTCCTGCGCGACCGCACGG
ACCGCGCCTGA

Upstream 100 bases:

>100_bases
CATCAAATTCTTGAAGGCACCAACGAAATCATGCGCGTCATCATCGCCCGTCACATGATTGGCCGTTAGAGCGCGAACTA
AAAGCAAGGGAGGTTTTATC

Downstream 100 bases:

>100_bases
AGAAAAAACGCTTTCCGGCAAAAAACTTGCATTATTTAGATTTGCTTAAGTGTCTGATAACGGTCCGGTAACGATATCCG
GCTAGAAAGGAGCACGAGAC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MATIAFIGLGNMGGPMAANLVKAGHTVRGFDLLPQHLEEAKANGLEIAASAAEAVSDVDAVITMLPAGKHVISVYENIAP
KARKDSLFVDCSTIDVDSARKAHELAATHGHLSIDAPVSGGTGGAAAGTLTVMAGGSEEAFKRGEPILQPMAGKIVHCGG
DGAGQAAKICNNMILGISMIGVSEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPASPANNDYKPGFAAAL
MLKDLKLSQEAAKSAGAETPLGAHARELYSRFDDEGHGGEDFSGIINFLRDRTDRA

Sequences:

>Translated_296_residues
MATIAFIGLGNMGGPMAANLVKAGHTVRGFDLLPQHLEEAKANGLEIAASAAEAVSDVDAVITMLPAGKHVISVYENIAP
KARKDSLFVDCSTIDVDSARKAHELAATHGHLSIDAPVSGGTGGAAAGTLTVMAGGSEEAFKRGEPILQPMAGKIVHCGG
DGAGQAAKICNNMILGISMIGVSEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPASPANNDYKPGFAAAL
MLKDLKLSQEAAKSAGAETPLGAHARELYSRFDDEGHGGEDFSGIINFLRDRTDRA
>Mature_295_residues
ATIAFIGLGNMGGPMAANLVKAGHTVRGFDLLPQHLEEAKANGLEIAASAAEAVSDVDAVITMLPAGKHVISVYENIAPK
ARKDSLFVDCSTIDVDSARKAHELAATHGHLSIDAPVSGGTGGAAAGTLTVMAGGSEEAFKRGEPILQPMAGKIVHCGGD
GAGQAAKICNNMILGISMIGVSEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPASPANNDYKPGFAAALM
LKDLKLSQEAAKSAGAETPLGAHARELYSRFDDEGHGGEDFSGIINFLRDRTDRA

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=42.2680412371134, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=25.9649122807018, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=35.5932203389831, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI145693186, Length=285, Percent_Identity=32.9824561403509, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786719, Length=296, Percent_Identity=33.445945945946, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788341, Length=212, Percent_Identity=28.7735849056604, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=41.4141414141414, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=42.9065743944637, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=42.9065743944637, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI28574115, Length=295, Percent_Identity=23.728813559322, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30452; Mature: 30321

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIAFIGLGNMGGPMAANLVKAGHTVRGFDLLPQHLEEAKANGLEIAASAAEAVSDVDA
CCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
VITMLPAGKHVISVYENIAPKARKDSLFVDCSTIDVDSARKAHELAATHGHLSIDAPVSG
HHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCC
GTGGAAAGTLTVMAGGSEEAFKRGEPILQPMAGKIVHCGGDGAGQAAKICNNMILGISMI
CCCCCCCCEEEEEECCCHHHHHCCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
GVSEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPASPANNDYKPGFAAAL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHH
MLKDLKLSQEAAKSAGAETPLGAHARELYSRFDDEGHGGEDFSGIINFLRDRTDRA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATIAFIGLGNMGGPMAANLVKAGHTVRGFDLLPQHLEEAKANGLEIAASAAEAVSDVDA
CEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
VITMLPAGKHVISVYENIAPKARKDSLFVDCSTIDVDSARKAHELAATHGHLSIDAPVSG
HHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCC
GTGGAAAGTLTVMAGGSEEAFKRGEPILQPMAGKIVHCGGDGAGQAAKICNNMILGISMI
CCCCCCCCEEEEEECCCHHHHHCCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
GVSEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPASPANNDYKPGFAAAL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHH
MLKDLKLSQEAAKSAGAETPLGAHARELYSRFDDEGHGGEDFSGIINFLRDRTDRA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]