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The map label for this gene is acdA [H]

Identifier: 225852804

GI number: 225852804

Start: 1292808

End: 1293965

Strand: Direct

Name: acdA [H]

Synonym: BMEA_A1361

Alternate gene names: 225852804

Gene position: 1292808-1293965 (Clockwise)

Preceding gene: 225852794

Following gene: 225852805

Centisome position: 60.82

GC content: 57.43

Gene sequence:

>1158_bases
ATGGATACTGCCGATCAGAACCAGTTTGAACTGAATGAGGATCAATGCGCCATTCAGGAGATGGCGCAGGCCTTTGCCGC
CGACCGGATCGCACCGCAGGCCCTGCAATGGGACCGCGACAAGCATTTCCCCGTCGATATCCTGCGTGAGACAGGGCCGC
TCGGCATGGGCGGCATTTACGTGCGCGACGATGTGGGTGGATCGGGGCTGAAACGGCTTGATGCGGTGCTTATTTTTGAG
GCGCTCGCCACGGCTTGCCCGACATTCTCGGCCTTTCTGTCCATCCATAACATGGCCGCATGGATGATCGACACCTTTGG
CAATGAGAAACAGCGCCAGCGCTTCCTACCGCAATTGACTTCCATGGAATGGCTGGCAAGCTATTGCCTGACGGAGCCGG
GTTCGGGTTCCGACGCGGCAGCACTCAAGACCCGCGCCGTGCGCGACGGCGACCATTATATCGTCAACGGCGCAAAGCAG
TTCATATCGGGTGCGGGTTCCACCGATCTCTATGTTACCATGGTGCGTACCGGCGAGGACGGCCCAAAAGGCATTTCCAC
GCTCGTTGTGCCTAAAGATGCACCGGGCCTGTCTTTCGGCGCCAATGAATATAAAATGGGCTGGAATGCCCAGCCGACCC
GCACGGTTATTTTTGACAACTGCCGCGTGCCGGTGGAAAATCGTTTGGGCGATGAAGGCGTCGGCTTCAAAATCGCCATG
CCGGGCCTTGATGGCGGGCGCCTCAATATTGCGGCCTGTTCGCTTGGCGGTGCGCAAGCTGCAACGGCGAAAGCGCTGGA
ATATTGCGCCGAGCGCAAGGCTTTCGGACAAACGATCGATCGTTTTCAGGCCTTGCAGTTCCGCCTAGCCGATATGGAAA
CAGAATTGGCCGCCTCGCGCATGCTTCTTTATACGGCCGCAAGCAAGCTCGACCGCAAGACCCATGACGCAGGCAAATGG
TCAGCCATGGCGAAACGCTTCGTGACCGATACGAGCTTCAATGTTGCCAACGAAGCCCTCCAGCTTCTGGGCGGTTACGG
CTATCTTCACGATTATGGCATCGAGAAACTGGTGCGCGATCTGCGCGTTCATCAAATTCTTGAAGGCACCAACGAAATCA
TGCGCGTCATCATCGCCCGTCACATGATTGGCCGTTAG

Upstream 100 bases:

>100_bases
GGTTACAAATGTGCGCAACATTATTCCAAAGGAGCGTTGGCAGCCCCCTGCTCTTGTGCTCTAGTCGACGCATGAAAGCG
GTGCTCATAGGGAGGAAACC

Downstream 100 bases:

>100_bases
AGCGCGAACTAAAAGCAAGGGAGGTTTTATCATGGCCACAATCGCATTTATCGGCCTCGGCAATATGGGAGGCCCAATGG
CCGCCAATCTGGTCAAGGCA

Product: acyl-CoA dehydrogenase

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDTADQNQFELNEDQCAIQEMAQAFAADRIAPQALQWDRDKHFPVDILRETGPLGMGGIYVRDDVGGSGLKRLDAVLIFE
ALATACPTFSAFLSIHNMAAWMIDTFGNEKQRQRFLPQLTSMEWLASYCLTEPGSGSDAAALKTRAVRDGDHYIVNGAKQ
FISGAGSTDLYVTMVRTGEDGPKGISTLVVPKDAPGLSFGANEYKMGWNAQPTRTVIFDNCRVPVENRLGDEGVGFKIAM
PGLDGGRLNIAACSLGGAQAATAKALEYCAERKAFGQTIDRFQALQFRLADMETELAASRMLLYTAASKLDRKTHDAGKW
SAMAKRFVTDTSFNVANEALQLLGGYGYLHDYGIEKLVRDLRVHQILEGTNEIMRVIIARHMIGR

Sequences:

>Translated_385_residues
MDTADQNQFELNEDQCAIQEMAQAFAADRIAPQALQWDRDKHFPVDILRETGPLGMGGIYVRDDVGGSGLKRLDAVLIFE
ALATACPTFSAFLSIHNMAAWMIDTFGNEKQRQRFLPQLTSMEWLASYCLTEPGSGSDAAALKTRAVRDGDHYIVNGAKQ
FISGAGSTDLYVTMVRTGEDGPKGISTLVVPKDAPGLSFGANEYKMGWNAQPTRTVIFDNCRVPVENRLGDEGVGFKIAM
PGLDGGRLNIAACSLGGAQAATAKALEYCAERKAFGQTIDRFQALQFRLADMETELAASRMLLYTAASKLDRKTHDAGKW
SAMAKRFVTDTSFNVANEALQLLGGYGYLHDYGIEKLVRDLRVHQILEGTNEIMRVIIARHMIGR
>Mature_385_residues
MDTADQNQFELNEDQCAIQEMAQAFAADRIAPQALQWDRDKHFPVDILRETGPLGMGGIYVRDDVGGSGLKRLDAVLIFE
ALATACPTFSAFLSIHNMAAWMIDTFGNEKQRQRFLPQLTSMEWLASYCLTEPGSGSDAAALKTRAVRDGDHYIVNGAKQ
FISGAGSTDLYVTMVRTGEDGPKGISTLVVPKDAPGLSFGANEYKMGWNAQPTRTVIFDNCRVPVENRLGDEGVGFKIAM
PGLDGGRLNIAACSLGGAQAATAKALEYCAERKAFGQTIDRFQALQFRLADMETELAASRMLLYTAASKLDRKTHDAGKW
SAMAKRFVTDTSFNVANEALQLLGGYGYLHDYGIEKLVRDLRVHQILEGTNEIMRVIIARHMIGR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=57.1045576407507, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI4557231, Length=384, Percent_Identity=36.1979166666667, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI187960098, Length=384, Percent_Identity=36.1979166666667, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=36.1702127659575, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=35.978835978836, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=32.7127659574468, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557235, Length=335, Percent_Identity=34.9253731343284, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI76496475, Length=335, Percent_Identity=34.9253731343284, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=33.6309523809524, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4501857, Length=363, Percent_Identity=31.404958677686, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI21361497, Length=387, Percent_Identity=32.5581395348837, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4503943, Length=382, Percent_Identity=30.1047120418848, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7669494, Length=352, Percent_Identity=30.3977272727273, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=26.7123287671233, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=27.1777003484321, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=27.1777003484321, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=27.7044854881267, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081958, Length=351, Percent_Identity=28.7749287749288, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082384, Length=264, Percent_Identity=26.1363636363636, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=47.2148541114058, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17569725, Length=384, Percent_Identity=36.71875, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=37.7604166666667, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=33.0708661417323, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=33.7801608579088, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=34.1397849462366, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=34.8958333333333, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=31.728045325779, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=35.7400722021661, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=38.695652173913, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=30.9333333333333, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=30.2139037433155, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=296, Percent_Identity=31.4189189189189, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.021897810219, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=25.9259259259259, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=28.0487804878049, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=251, Percent_Identity=29.8804780876494, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=289, Percent_Identity=29.757785467128, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI86563381, Length=330, Percent_Identity=27.5757575757576, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=36.4583333333333, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=34.9333333333333, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.5, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=35.2150537634409, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=33.1578947368421, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI281363737, Length=339, Percent_Identity=34.2182890855457, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=28.9473684210526, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45550141, Length=314, Percent_Identity=23.5668789808917, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221473076, Length=314, Percent_Identity=23.5668789808917, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 42219; Mature: 42219

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTADQNQFELNEDQCAIQEMAQAFAADRIAPQALQWDRDKHFPVDILRETGPLGMGGIY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHCCCCCCCCCEE
VRDDVGGSGLKRLDAVLIFEALATACPTFSAFLSIHNMAAWMIDTFGNEKQRQRFLPQLT
EECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SMEWLASYCLTEPGSGSDAAALKTRAVRDGDHYIVNGAKQFISGAGSTDLYVTMVRTGED
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHCCCCCCCEEEEEEEECCC
GPKGISTLVVPKDAPGLSFGANEYKMGWNAQPTRTVIFDNCRVPVENRLGDEGVGFKIAM
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCCCEEEEC
PGLDGGRLNIAACSLGGAQAATAKALEYCAERKAFGQTIDRFQALQFRLADMETELAASR
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLYTAASKLDRKTHDAGKWSAMAKRFVTDTSFNVANEALQLLGGYGYLHDYGIEKLVRD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRVHQILEGTNEIMRVIIARHMIGR
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTADQNQFELNEDQCAIQEMAQAFAADRIAPQALQWDRDKHFPVDILRETGPLGMGGIY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHCCCCCCCCCEE
VRDDVGGSGLKRLDAVLIFEALATACPTFSAFLSIHNMAAWMIDTFGNEKQRQRFLPQLT
EECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SMEWLASYCLTEPGSGSDAAALKTRAVRDGDHYIVNGAKQFISGAGSTDLYVTMVRTGED
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHCCCCCCCEEEEEEEECCC
GPKGISTLVVPKDAPGLSFGANEYKMGWNAQPTRTVIFDNCRVPVENRLGDEGVGFKIAM
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCCCEEEEC
PGLDGGRLNIAACSLGGAQAATAKALEYCAERKAFGQTIDRFQALQFRLADMETELAASR
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLYTAASKLDRKTHDAGKWSAMAKRFVTDTSFNVANEALQLLGGYGYLHDYGIEKLVRD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRVHQILEGTNEIMRVIIARHMIGR
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]