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The map label for this gene is tmk

Identifier: 225852497

GI number: 225852497

Start: 975188

End: 975832

Strand: Direct

Name: tmk

Synonym: BMEA_A1033

Alternate gene names: 225852497

Gene position: 975188-975832 (Clockwise)

Preceding gene: 225852496

Following gene: 225852498

Centisome position: 45.88

GC content: 57.67

Gene sequence:

>645_bases
GTGTCGGGATTGTTCATCACATTTGAAGGTGGAGAAGGCGCAGGCAAATCGACCCAGATTGCCTTGCTCGCCAGTCATCT
TCGTAACCATGGCTTCGATCCCGTTATCACGCGGGAGCCGGGCGGTTCGCCGGGGGCTGAAGCCATTCGCCACGTCATCT
TGAGCGGAAATGCCGAAACTTATGGTCCGGCCATGGAAGCCTTGCTGTTTGCTGCCGCCCGCGCGGACCATGTGGACCAG
TTGATCCGCCCGACATTGGCTGAAGGGCGCATTGTCCTGTGTGACCGCTTCATTGATTCGAGCCGGGCTTATCAGGGCGT
GACGGGCAATCTCGACGCGACCTATATGGCTGCCATTGAACGCATAGCGATTGATGGCGCTATGCCGGACCTGACGCTTG
TTCTCGATATTTGCGCGGAACGGGGACTGTCGCGTGCGGGCAAGCGGCGCGGAAGTGACACGGCGGATCGTTTCGAGAAG
GAAGATATTGCCGTCCATGAGGCGCGCCGTCAGGCATTTCTGGAAATCGCACGGCAAGAACCGGCGCGCTGCAAGGTCAT
TGATGCCGACCGTTCTCAGGAAAAAATTGCCGATGAAATCCGCTCTGTCGTGGACACGATCCTGACGGAAAAAGGGCTTT
TATGA

Upstream 100 bases:

>100_bases
GCTCAGGAAATACCTTTGAAGGCTCGACCTCGCGCTTAAAGGCCGATATTAAACAGTGTGAGGCCCATTCGGGCATGGAT
TCATTTGTTCGGATGCCAGA

Downstream 100 bases:

>100_bases
TCGAAGAGCTGGACATTCCCAAAACACATGATGCCATTGAAGGCGTCCCCGGACCCTCGGCCAGCGCCTATCTGGCGGGG
CATGACGAGATCGCGCGTTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAETYGPAMEALLFAAARADHVDQ
LIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIERIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEK
EDIAVHEARRQAFLEIARQEPARCKVIDADRSQEKIADEIRSVVDTILTEKGLL

Sequences:

>Translated_214_residues
MSGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAETYGPAMEALLFAAARADHVDQ
LIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIERIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEK
EDIAVHEARRQAFLEIARQEPARCKVIDADRSQEKIADEIRSVVDTILTEKGLL
>Mature_213_residues
SGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAETYGPAMEALLFAAARADHVDQL
IRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIERIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEKE
DIAVHEARRQAFLEIARQEPARCKVIDADRSQEKIADEIRSVVDTILTEKGLL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=36.9158878504673, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_BRUA1 (B2S5K6)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934927.1
- ProteinModelPortal:   B2S5K6
- SMR:   B2S5K6
- GeneID:   6328488
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I09380
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK13973
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23172; Mature: 23040

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAET
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCH
YGPAMEALLFAAARADHVDQLIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHHH
RIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEKEDIAVHEARRQAFLEIARQE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PARCKVIDADRSQEKIADEIRSVVDTILTEKGLL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAET
CCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCH
YGPAMEALLFAAARADHVDQLIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHHH
RIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEKEDIAVHEARRQAFLEIARQE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PARCKVIDADRSQEKIADEIRSVVDTILTEKGLL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA