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The map label for this gene is nuoH

Identifier: 225852325

GI number: 225852325

Start: 807969

End: 809012

Strand: Direct

Name: nuoH

Synonym: BMEA_A0851

Alternate gene names: 225852325

Gene position: 807969-809012 (Clockwise)

Preceding gene: 225852324

Following gene: 225852326

Centisome position: 38.01

GC content: 55.27

Gene sequence:

>1044_bases
ATGGAAGGAATTTTTGCAGCTTACGTCTTGCCCGCGCTTATCATAGCGCTGAAGTCGGTCGTTCTGCTCGTCGTATTGCT
GATCGTCGTCGCTTACCTGCTTTACGCGGATCGCAAGATCTGGGCAGCGGTACAGCTTCGTCGCGGCCCGAACGTCGTCG
GTCCCTGGGGTCTGTTCCAGGCCTTCGCCGACTTGTTGAAGTTCGTCTTCAAGGAACCGATCATCCCGTCTGGCGCAAAC
AAGGGTGTCTTCCTCCTTGCGCCTTTCATTTCCGCCGTTCTTGCAATGGCAACCTGGGCGGTTATTCCGGTCAATGAAGG
CTGGGCGGTCGCCAATATCAATGTCGGCATTCTCTATATCTTTGCCATTTCTTCGCTCGAAGTTTATGGCGTCATCATGG
GCGGCTGGGCATCGAATTCGAAATATCCGTTCCTCGGTGCGCTTCGTTCTGCCGCGCAGATGGTTTCCTATGAAGTTTCC
ATCGGTTTCGTGATTGTCACGGTTCTCTTGACGGTTGGCTCGCTCAACCTGACCGATATCGTGCTGTCGCAGAATACGGG
TCTGGGCACCATGCTTGGCCTGCCGGCTTCGTTCCTCGACTGGAACTGGCTCTGCCTGTTCCCGATGTTCGTCGTCTTCT
TCATTTCGGCACTTGCTGAAACGAACCGCCCGCCATTCGACCTTGTGGAAGCTGAATCCGAACTCGTGGCCGGTCACATG
ATCGAATATTCATCCACGCCGTTCCTTCTGTTCTTCCTCGGCGAATATGTGGCGATCACGCTGATGTGCGCCCTCATGAC
TGTGCTTTTCCTCGGCGGCTGGCTGCCTCCGGTGGATGTGTGGTTCCTCAGCTGGGTTCCGGGCATCATCTGGTTCATGC
TGAAGCTCTGCTTCTGCTTCTTCCTCTTCGCAATGGTGAAGGCTTTCGTTCCGCGTTATCGCTACGACCAGCTCATGCGC
CTTGGCTGGAAAGTGTTCCTGCCGATCTCGCTCTTCATGGTTGTCGCAACCGCGACCTTCCTCAAAGTCTTCGGTCTGGC
GTAA

Upstream 100 bases:

>100_bases
AACCCAATCGCGCGCGCTTCCGCCGTCATGGCCGAATGCTCGGCGCTCGCGGCCGGCGGCTTCCAACAGGCAGCTGAGTA
AGCGAGAGAGAGACGGAACA

Downstream 100 bases:

>100_bases
GGAGTAAAACTCATGGCTTCAATCGCTCAAGCAGCCAAATCGCTCCTGTTGAAGGAATTCGCCAGCGCGTTCGCTCTTTC
CATGCGCCAGTTCTTCGCGC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MEGIFAAYVLPALIIALKSVVLLVVLLIVVAYLLYADRKIWAAVQLRRGPNVVGPWGLFQAFADLLKFVFKEPIIPSGAN
KGVFLLAPFISAVLAMATWAVIPVNEGWAVANINVGILYIFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLTVGSLNLTDIVLSQNTGLGTMLGLPASFLDWNWLCLFPMFVVFFISALAETNRPPFDLVEAESELVAGHM
IEYSSTPFLLFFLGEYVAITLMCALMTVLFLGGWLPPVDVWFLSWVPGIIWFMLKLCFCFFLFAMVKAFVPRYRYDQLMR
LGWKVFLPISLFMVVATATFLKVFGLA

Sequences:

>Translated_347_residues
MEGIFAAYVLPALIIALKSVVLLVVLLIVVAYLLYADRKIWAAVQLRRGPNVVGPWGLFQAFADLLKFVFKEPIIPSGAN
KGVFLLAPFISAVLAMATWAVIPVNEGWAVANINVGILYIFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLTVGSLNLTDIVLSQNTGLGTMLGLPASFLDWNWLCLFPMFVVFFISALAETNRPPFDLVEAESELVAGHM
IEYSSTPFLLFFLGEYVAITLMCALMTVLFLGGWLPPVDVWFLSWVPGIIWFMLKLCFCFFLFAMVKAFVPRYRYDQLMR
LGWKVFLPISLFMVVATATFLKVFGLA
>Mature_347_residues
MEGIFAAYVLPALIIALKSVVLLVVLLIVVAYLLYADRKIWAAVQLRRGPNVVGPWGLFQAFADLLKFVFKEPIIPSGAN
KGVFLLAPFISAVLAMATWAVIPVNEGWAVANINVGILYIFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLTVGSLNLTDIVLSQNTGLGTMLGLPASFLDWNWLCLFPMFVVFFISALAETNRPPFDLVEAESELVAGHM
IEYSSTPFLLFFLGEYVAITLMCALMTVLFLGGWLPPVDVWFLSWVPGIIWFMLKLCFCFFLFAMVKAFVPRYRYDQLMR
LGWKVFLPISLFMVVATATFLKVFGLA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=302, Percent_Identity=40.7284768211921, Blast_Score=227, Evalue=9e-60,
Organism=Escherichia coli, GI1788618, Length=326, Percent_Identity=41.4110429447853, Blast_Score=248, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_BRUA2 (Q2YNF6)

Other databases:

- EMBL:   AM040264
- RefSeq:   YP_414260.1
- STRING:   Q2YNF6
- GeneID:   3788823
- GenomeReviews:   AM040264_GR
- KEGG:   bmf:BAB1_0829
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- ProtClustDB:   PRK06076
- BioCyc:   BMEL359391:BAB1_0829-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38429; Mature: 38429

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f804604)-; HASH(0x21d78424)-; HASH(0x21cdadb4)-; HASH(0x21d4c038)-; HASH(0x21c4d200)-; HASH(0x21cb4b9c)-; HASH(0x21c40834)-; HASH(0x21d529b0)-; HASH(0x21d78298)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIFAAYVLPALIIALKSVVLLVVLLIVVAYLLYADRKIWAAVQLRRGPNVVGPWGLFQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHH
AFADLLKFVFKEPIIPSGANKGVFLLAPFISAVLAMATWAVIPVNEGWAVANINVGILYI
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHH
FAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLTVGSLNLTDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHE
VLSQNTGLGTMLGLPASFLDWNWLCLFPMFVVFFISALAETNRPPFDLVEAESELVAGHM
EEECCCCCHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IEYSSTPFLLFFLGEYVAITLMCALMTVLFLGGWLPPVDVWFLSWVPGIIWFMLKLCFCF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLFAMVKAFVPRYRYDQLMRLGWKVFLPISLFMVVATATFLKVFGLA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MEGIFAAYVLPALIIALKSVVLLVVLLIVVAYLLYADRKIWAAVQLRRGPNVVGPWGLFQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHH
AFADLLKFVFKEPIIPSGANKGVFLLAPFISAVLAMATWAVIPVNEGWAVANINVGILYI
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHH
FAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLTVGSLNLTDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHE
VLSQNTGLGTMLGLPASFLDWNWLCLFPMFVVFFISALAETNRPPFDLVEAESELVAGHM
EEECCCCCHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IEYSSTPFLLFFLGEYVAITLMCALMTVLFLGGWLPPVDVWFLSWVPGIIWFMLKLCFCF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLFAMVKAFVPRYRYDQLMRLGWKVFLPISLFMVVATATFLKVFGLA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA