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The map label for this gene is nuoF [H]

Identifier: 225852323

GI number: 225852323

Start: 804423

End: 805730

Strand: Direct

Name: nuoF [H]

Synonym: BMEA_A0849

Alternate gene names: 225852323

Gene position: 804423-805730 (Clockwise)

Preceding gene: 225852322

Following gene: 225852324

Centisome position: 37.84

GC content: 59.4

Gene sequence:

>1308_bases
ATGCTGGCTGACAAAGATCGCATCTTCACCAATATTTACGGCTTCAAGGATCAGTCCCTGAAGGGTGCCATGGCTCGTGG
CCATTGGGACAATACCAAGGGCCTGATCGAGAAGGGCCGCGACTGGATCATCGAGGAGATGAAGGCGTCGGGCCTGCGTG
GCCGTGGCGGCGCTGGCTTCCCGACGGGTCTCAAATGGTCGTTCATGCCCAAGCAGAGCGATGGTCGCCCGCATTACCTC
GTCGTCAATGCCGACGAATCGGAGCCGGGCACCTGCAAGGACCGCGAAATCCTGCGCCACGATCCGCATACGCTGATCGA
AGGCTGCGTGATTGCCGGTTGCGCGATGGGCGTACACACCGCTTATATTTATATTCGCGGCGAGTTCATGCGTGAGCGTG
AGGCGCTTCAGGCTGCAATCGACGAGTGCTACGAAGCCGGCCTTCTCGGCAAGAACAACAAGTGCGGCTGGGATATGGAC
ATTTATGTCACCCACGGCGCTGGCGCTTATATCTGCGGTGAAGAAACGGCTCTGCTCGAAAGCCTCGAAGGCAAGAAGGG
TCAGCCGCGCCTCAAGCCTCCATTCCCGGCCAATATGGGCCTCTACGGTTGCCCGACGACGGTCAACAACGTGGAATCGA
TTGCCGTTGCGCCGACGATCCTGCGTCGTGGCGCGGCATGGTTCTCGTCCATCGGACGTCCGAACAATGTCGGCACCAAG
CTGTTCCAGATGTCCGGCCATGTGAACACGCCGTGCGTCGTGGAAGAGGGGCTCGGCATTCCGTTCCGCGAGCTGATCGA
AAAGCATGGCGGCGGTATCCGTGGCGGCTGGGACAATCTGCTGGCGGTCATTCCCGGCGGCGCGTCGTGCCCGGTCATCA
AGGCCGAGGACATGATGGACGCCGTCATGGATTTTGATGGCATGCGTGAGAAGAAGTCGTCCTTCGGCACCGGCGGCTTG
ATCGTCATGGACAAGTCCACCGACATCATCAAGGCGATTGCGCGCCTGTCTGCCTTCTTCAAGCATGAGAGCTGCGGCCA
GTGCACGCCGTGCCGCGAAGGCACTGGCTGGATGTGGCGCGTGATGGAGCGCATGGTCAAGGGTAACGCGCAGAAGCGTG
AAATCGACATGCTGTTCGACGTCACCAAGCAGATCGAAGGTCACACGATCTGCGCGCTCGGTGATGCGGCCGCATGGCCG
ATCCAGGGGCTGATTCGCAATTTCCGTCCGGAAATTGAAAAGCGCATTGATGAATATACTCGCAACGCCGTTCAGAGCCG
TAATATCCGTCTGGAAGCGGCTGAATAA

Upstream 100 bases:

>100_bases
CAAGAAGATCGGCCTCGAAACCCGCAAGGCGTCGGATGCAGCAGCAGCTAAAGCTAAGGCCGAAGCCGAGGCAGCAACAA
AAGACGGAAACAGGTGAGAC

Downstream 100 bases:

>100_bases
GTTGTGTGAGCCTGCCCGACAGGGCATGACCCCGAAAAGTGCCTGGCGGTTTTCGGAAAAGGCCATGCCAATCAAGCGCA
GGTACAAAAGTTTGAGATGG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLADKDRIFTNIYGFKDQSLKGAMARGHWDNTKGLIEKGRDWIIEEMKASGLRGRGGAGFPTGLKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREILRHDPHTLIEGCVIAGCAMGVHTAYIYIRGEFMREREALQAAIDECYEAGLLGKNNKCGWDMD
IYVTHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
LFQMSGHVNTPCVVEEGLGIPFRELIEKHGGGIRGGWDNLLAVIPGGASCPVIKAEDMMDAVMDFDGMREKKSSFGTGGL
IVMDKSTDIIKAIARLSAFFKHESCGQCTPCREGTGWMWRVMERMVKGNAQKREIDMLFDVTKQIEGHTICALGDAAAWP
IQGLIRNFRPEIEKRIDEYTRNAVQSRNIRLEAAE

Sequences:

>Translated_435_residues
MLADKDRIFTNIYGFKDQSLKGAMARGHWDNTKGLIEKGRDWIIEEMKASGLRGRGGAGFPTGLKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREILRHDPHTLIEGCVIAGCAMGVHTAYIYIRGEFMREREALQAAIDECYEAGLLGKNNKCGWDMD
IYVTHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
LFQMSGHVNTPCVVEEGLGIPFRELIEKHGGGIRGGWDNLLAVIPGGASCPVIKAEDMMDAVMDFDGMREKKSSFGTGGL
IVMDKSTDIIKAIARLSAFFKHESCGQCTPCREGTGWMWRVMERMVKGNAQKREIDMLFDVTKQIEGHTICALGDAAAWP
IQGLIRNFRPEIEKRIDEYTRNAVQSRNIRLEAAE
>Mature_435_residues
MLADKDRIFTNIYGFKDQSLKGAMARGHWDNTKGLIEKGRDWIIEEMKASGLRGRGGAGFPTGLKWSFMPKQSDGRPHYL
VVNADESEPGTCKDREILRHDPHTLIEGCVIAGCAMGVHTAYIYIRGEFMREREALQAAIDECYEAGLLGKNNKCGWDMD
IYVTHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
LFQMSGHVNTPCVVEEGLGIPFRELIEKHGGGIRGGWDNLLAVIPGGASCPVIKAEDMMDAVMDFDGMREKKSSFGTGGL
IVMDKSTDIIKAIARLSAFFKHESCGQCTPCREGTGWMWRVMERMVKGNAQKREIDMLFDVTKQIEGHTICALGDAAAWP
IQGLIRNFRPEIEKRIDEYTRNAVQSRNIRLEAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=66.109785202864, Blast_Score=597, Evalue=1e-171,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=66.109785202864, Blast_Score=595, Evalue=1e-170,
Organism=Escherichia coli, GI1788620, Length=393, Percent_Identity=41.7302798982188, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17531727, Length=430, Percent_Identity=63.7209302325581, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI19920794, Length=421, Percent_Identity=67.6959619952494, Blast_Score=612, Evalue=1e-175,
Organism=Drosophila melanogaster, GI45550452, Length=418, Percent_Identity=67.7033492822967, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24653819, Length=426, Percent_Identity=45.7746478873239, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24653817, Length=426, Percent_Identity=42.9577464788732, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48023; Mature: 48023

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADKDRIFTNIYGFKDQSLKGAMARGHWDNTKGLIEKGRDWIIEEMKASGLRGRGGAGF
CCCCCHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKQSDGRPHYLVVNADESEPGTCKDREILRHDPHTLIEGCVIAGCAMGVHT
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHEE
AYIYIRGEFMREREALQAAIDECYEAGLLGKNNKCGWDMDIYVTHGAGAYICGEETALLE
EEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LFQMSGHVNTPCVVEEGLGIPFRELIEKHGGGIRGGWDNLLAVIPGGASCPVIKAEDMMD
HHEECCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHH
AVMDFDGMREKKSSFGTGGLIVMDKSTDIIKAIARLSAFFKHESCGQCTPCREGTGWMWR
HHHHHCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERMVKGNAQKREIDMLFDVTKQIEGHTICALGDAAAWPIQGLIRNFRPEIEKRIDEYT
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
RNAVQSRNIRLEAAE
HHHHHHCCEEEEECC
>Mature Secondary Structure
MLADKDRIFTNIYGFKDQSLKGAMARGHWDNTKGLIEKGRDWIIEEMKASGLRGRGGAGF
CCCCCHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKQSDGRPHYLVVNADESEPGTCKDREILRHDPHTLIEGCVIAGCAMGVHT
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHEE
AYIYIRGEFMREREALQAAIDECYEAGLLGKNNKCGWDMDIYVTHGAGAYICGEETALLE
EEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSIGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LFQMSGHVNTPCVVEEGLGIPFRELIEKHGGGIRGGWDNLLAVIPGGASCPVIKAEDMMD
HHEECCCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHH
AVMDFDGMREKKSSFGTGGLIVMDKSTDIIKAIARLSAFFKHESCGQCTPCREGTGWMWR
HHHHHCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERMVKGNAQKREIDMLFDVTKQIEGHTICALGDAAAWPIQGLIRNFRPEIEKRIDEYT
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
RNAVQSRNIRLEAAE
HHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]