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The map label for this gene is pyrE

Identifier: 225852174

GI number: 225852174

Start: 664320

End: 664898

Strand: Direct

Name: pyrE

Synonym: BMEA_A0690

Alternate gene names: 225852174

Gene position: 664320-664898 (Clockwise)

Preceding gene: 225852173

Following gene: 225852175

Centisome position: 31.25

GC content: 60.45

Gene sequence:

>579_bases
ATGAATACTGACGATGTGCTCGCCGTCTTCCGCGAAGCGGGAGCGATCCTTGAAGGCCATTTTATCCTCACCTCCGGCCT
GCGCAGCCCCGTTTTTCTACAGAAGGCGCGCGTGTTCATGCATGCCGACAAGACGGAAAAACTATGCAAGGCGCTTGCCG
AAAAGATCAGGGCGGCCGATCTCGGCCCCATCGATTATGTGGTCGGGCCGGCCATCGGCGGCCTGATCCCGTCTTACGAG
ACGTCCCGCCATCTGGGGGTTCCTTCGGTCTGGGTCGAACGCGAGAATGGCGTATTCCGCCTGCGTCGTTTCGACGTGCC
GAAGGGCGCGCGCGTCGTCATCGTGGAAGATATCGTCACCACGGGCCTTTCCATCCGCGAAACCATCGACTGCATGAAGG
ATCTTGGCATCGAGGTTGTCGCCGCAGCCTGTATCGTGGATCGCTCGGCGGGCAAGGCGGATGTTGGTACCCGGCTGATT
TCGCTGGCGGAATATGAAGTTCCAGCCTATCCGGCAGATAAGCTGCCGCCGGAACTGGCAGCCATTCCGGCCGTCAAGCC
CGGCAGCCGCAATATCTGA

Upstream 100 bases:

>100_bases
GTAGAGGTCTGGGACCTCAAGCATCTCAATCGCATCATCTCTCAATTGAAAGAAAGCGCGAGCGTCAGCAGCGCAAAGCG
TGTGAACGGATAGGACTGAA

Downstream 100 bases:

>100_bases
CCCAAACCCGTTTCGGGGCCGCTTTTGCGCGCGGAGTTTGAGGTACGCAATATCAGCCTCCAACCCTGCGGCGAAATTGC
GCTTTGCGATGCGCGTCGAG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAADLGPIDYVVGPAIGGLIPSYE
TSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLI
SLAEYEVPAYPADKLPPELAAIPAVKPGSRNI

Sequences:

>Translated_192_residues
MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAADLGPIDYVVGPAIGGLIPSYE
TSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLI
SLAEYEVPAYPADKLPPELAAIPAVKPGSRNI
>Mature_192_residues
MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAADLGPIDYVVGPAIGGLIPSYE
TSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLI
SLAEYEVPAYPADKLPPELAAIPAVKPGSRNI

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Caenorhabditis elegans, GI17508631, Length=136, Percent_Identity=30.8823529411765, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_BRUA1 (B2SAD1)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934635.1
- ProteinModelPortal:   B2SAD1
- SMR:   B2SAD1
- GeneID:   6327791
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I06300
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20733; Mature: 20733

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 120-120 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAAD
CCCHHHHHHHHHCCCEEECCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
LGPIDYVVGPAIGGLIPSYETSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEEEEHHHHH
TGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLISLAEYEVPAYPADKLPPELA
CCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
AIPAVKPGSRNI
HCCCCCCCCCCC
>Mature Secondary Structure
MNTDDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIRAAD
CCCHHHHHHHHHCCCEEECCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
LGPIDYVVGPAIGGLIPSYETSRHLGVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEEEEHHHHH
TGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTRLISLAEYEVPAYPADKLPPELA
CCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
AIPAVKPGSRNI
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA