Click here to switch to the map view.

The map label for this gene is rsh [H]

Identifier: 225852173

GI number: 225852173

Start: 662060

End: 664312

Strand: Direct

Name: rsh [H]

Synonym: BMEA_A0689

Alternate gene names: 225852173

Gene position: 662060-664312 (Clockwise)

Preceding gene: 225852172

Following gene: 225852174

Centisome position: 31.15

GC content: 57.88

Gene sequence:

>2253_bases
ATGATGCGCCAATATGAGCTTGTGGAGCGTGTGCAGCGATACAAGCCTGATGTGAACGAGGCGCTTCTTAACAAGGCATA
TGTTTATGCCATGCAGAAACACGGCAGTCAGAAGCGGGCTTCCGGCGATCCCTATTTCTCCCATCCGCTGGAAGTGGCGG
CTATTCTCACAGATATGCATTTGGACGAGGCGACAATCGCCATCGCGCTTCTGCACGACACGATCGAGGATACCACGGCC
ACCCGGCAGGAAATCGACCAGCTTTTCGGGCCGGAAATCGGCAAGCTTGTCGAGGGGCTGACCAAGCTCAAGAAACTCGA
TCTCGTTTCCAAGAAGGCTGTCCAGGCGGAAAACCTGCGTAAACTTCTGCTGGCGATTTCAGAGGACGTGCGCGTTCTTC
TGGTAAAGCTTGCCGACCGTCTCCACAATATGCGTACGCTCGGCGTGATGCGCGAAGACAAGCGCCTGCGTATTGCCGAG
GAGACCATGGATATTTATGCGCCGCTCGCTGGCCGCATGGGTATGCAGGATATGCGTGAGGAGCTGGAGGAGCTGGCTTT
CCGCTATATCAATCCCGATGCATGGCGAGCCGTCACCGACAGGCTTGCCGAGCTTCTGGAAAAGAACCGCGGTCTTTTGC
AGAAGATCGAAACGGATCTCTCTGAAATTTTCGAGAAGAACGGCATCAAGGCCAGCGTGAAAAGCCGCCAGAAGAAGCCA
TGGTCGGTTTTCCGCAAGATGGAGAGCAAGGGCCTTTCCTTCGAGCAGCTTTCCGACATTTTCGGCTTCCGCGTCATGGT
CGATACGGTGCAGGATTGCTATCGTGCGCTTGGCCTGATCCACACCACATGGTCCATGGTTCCGGGACGGTTCAAGGATT
ATATCTCGACGCCGAAGCAGAACGATTATCGCTCCATCCATACCACCATCATCGGCCCGTCGCGCCAGCGTATCGAATTG
CAGATTCGCACGCGCGAAATGGATGAGATCGCTGAATTCGGCGTGGCGGCCCACTCCATTTACAAGGATCGTGGCAGCGC
CAACAACCCGCACAAGATTTCGACCGAGACCAACGCCTATGCATGGCTGCGCCAGACCATCGAGCAATTGTCTGAGGGCG
ACAATCCTGAAGAATTTCTGGAACACACCAAGCTTGAACTGTTTCAAGATCAGGTCTTCTGCTTCACGCCGAAAGGCAGG
CTGATCGCGCTGCCGCGCGGCGCGACGCCTATTGATTTTGCCTATGCCGTTCACACCGATATTGGCGACAGCTGCGTGGG
CGCGAAAGTCAATGGCCGCATCATGCCCTTGATGACGGAACTCAAGAATGGCGACGAAGTGGATATTATCCGCTCCAAGG
CGCAGGTTCCGCCCGCCGCCTGGGAATCGCTGGTTGCAACCGGCAAGGCGCGCGCGGCCATCCGCCGCGCCACACGCTCT
GCCGTGCGCAAGCAATATTCCGGCCTCGGGATGCGAATTCTGGAGCGTGCCTTTGAGCGCGCGGGCAAACCGTTCAGCAA
GGACATTTTGAAGCCTGGCCTGCCGCGTCTGGCGCGCAAGGATGTGGAAGACGTGCTTGCAGCCGTCGGGCGTGGGGAAC
TGCCCTCGACCGATGTGGTGAAGGCCGTCTATCCCGATTATCAGGACACTCGCGTCACCACGCAGAACAATCCTGCCAAG
GCTGGCGAGAAGGGCTGGTTCAATATCCAGAACGCCGCTGGCATGATCTTCAAGGTGCCGGAAGGAGGCGAGGGTGCTGC
TGCCAAGGTTGATCCGGCGGCAACGACGCCGAAGCCCGGCAAGCGCGCACTGCCCATTCGCGGAACCAATCCGGACCTGC
CTGTGCGTTTTGCGCCGGAAGGGGCCGTGCCGGGCGACCGCATCGTGGGCATCTTGCAGCCCGGCGCAGGCATCACGATC
TATCCCATCCAGTCGCCCGCACTGACGGCCTATGACGATCAGCCGGAGCGCTGGATCGACGTGCGCTGGGATATCGATGA
CCAGATGAGCGAGCGTTTCCCCGCGCGCATCAGCGTATCGGCAATCAACTCGCCCGGCTCTTTGGCGGAAATTGCCCAGA
TTGCGGCGGCAAATGATGCCAATATCCACAATCTCTCCATGGTGCGCACGGCGCCCGATTTTACGGAAATGATTATCGAT
GTAGAGGTCTGGGACCTCAAGCATCTCAATCGCATCATCTCTCAATTGAAAGAAAGCGCGAGCGTCAGCAGCGCAAAGCG
TGTGAACGGATAG

Upstream 100 bases:

>100_bases
AAAGATTGCTCAAGGATCGTGAGATATTCGTTTTTTTACGATTCCTGATTAAAATGGCCGATATCTCTGTATGTGTTTCG
GTTCGAGGGAGTTTCGGCAG

Downstream 100 bases:

>100_bases
GACTGAAATGAATACTGACGATGTGCTCGCCGTCTTCCGCGAAGCGGGAGCGATCCTTGAAGGCCATTTTATCCTCACCT
CCGGCCTGCGCAGCCCCGTT

Product: RelA/SpoT family protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGSQKRASGDPYFSHPLEVAAILTDMHLDEATIAIALLHDTIEDTTA
TRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLGVMREDKRLRIAE
ETMDIYAPLAGRMGMQDMREELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKP
WSVFRKMESKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIIGPSRQRIEL
QIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAYAWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGR
LIALPRGATPIDFAYAVHTDIGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRS
AVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVVKAVYPDYQDTRVTTQNNPAK
AGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPGKRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITI
YPIQSPALTAYDDQPERWIDVRWDIDDQMSERFPARISVSAINSPGSLAEIAQIAAANDANIHNLSMVRTAPDFTEMIID
VEVWDLKHLNRIISQLKESASVSSAKRVNG

Sequences:

>Translated_750_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGSQKRASGDPYFSHPLEVAAILTDMHLDEATIAIALLHDTIEDTTA
TRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLGVMREDKRLRIAE
ETMDIYAPLAGRMGMQDMREELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKP
WSVFRKMESKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIIGPSRQRIEL
QIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAYAWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGR
LIALPRGATPIDFAYAVHTDIGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRS
AVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVVKAVYPDYQDTRVTTQNNPAK
AGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPGKRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITI
YPIQSPALTAYDDQPERWIDVRWDIDDQMSERFPARISVSAINSPGSLAEIAQIAAANDANIHNLSMVRTAPDFTEMIID
VEVWDLKHLNRIISQLKESASVSSAKRVNG
>Mature_750_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGSQKRASGDPYFSHPLEVAAILTDMHLDEATIAIALLHDTIEDTTA
TRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLGVMREDKRLRIAE
ETMDIYAPLAGRMGMQDMREELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKP
WSVFRKMESKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIIGPSRQRIEL
QIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAYAWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGR
LIALPRGATPIDFAYAVHTDIGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRS
AVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVVKAVYPDYQDTRVTTQNNPAK
AGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPGKRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITI
YPIQSPALTAYDDQPERWIDVRWDIDDQMSERFPARISVSAINSPGSLAEIAQIAAANDANIHNLSMVRTAPDFTEMIID
VEVWDLKHLNRIISQLKESASVSSAKRVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=132, Percent_Identity=39.3939393939394, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790082, Length=733, Percent_Identity=36.6984993178718, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1789147, Length=746, Percent_Identity=30.4289544235925, Blast_Score=357, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25143118, Length=129, Percent_Identity=39.5348837209302, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650996, Length=125, Percent_Identity=38.4, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83901; Mature: 83901

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGSQKRASGDPYFSHPLEVAAILTDMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
LDEATIAIALLHDTIEDTTATRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISEDVRVLLVKLADRLHNMRTLGVMREDKRLRIAEETMDIYAPLAGRMGMQDMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
ELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHHCCCCH
WSVFRKMESKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NDYRSIHTTIIGPSRQRIELQIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAY
CCCCEEEEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHH
AWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGRLIALPRGATPIDFAYAVHTD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCEEEEEEECC
IGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRS
CCCCCCCCCCCCEEEHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
AVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVV
HHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
KAVYPDYQDTRVTTQNNPAKAGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPG
HHHCCCCCCCEEECCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
KRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITIYPIQSPALTAYDDQPERWID
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCEECCCCCCCCEEE
VRWDIDDQMSERFPARISVSAINSPGSLAEIAQIAAANDANIHNLSMVRTAPDFTEMIID
EEECCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHEEE
VEVWDLKHLNRIISQLKESASVSSAKRVNG
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGSQKRASGDPYFSHPLEVAAILTDMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
LDEATIAIALLHDTIEDTTATRQEIDQLFGPEIGKLVEGLTKLKKLDLVSKKAVQAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISEDVRVLLVKLADRLHNMRTLGVMREDKRLRIAEETMDIYAPLAGRMGMQDMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
ELEELAFRYINPDAWRAVTDRLAELLEKNRGLLQKIETDLSEIFEKNGIKASVKSRQKKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHHCCCCH
WSVFRKMESKGLSFEQLSDIFGFRVMVDTVQDCYRALGLIHTTWSMVPGRFKDYISTPKQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NDYRSIHTTIIGPSRQRIELQIRTREMDEIAEFGVAAHSIYKDRGSANNPHKISTETNAY
CCCCEEEEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHH
AWLRQTIEQLSEGDNPEEFLEHTKLELFQDQVFCFTPKGRLIALPRGATPIDFAYAVHTD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCEEEEEEECC
IGDSCVGAKVNGRIMPLMTELKNGDEVDIIRSKAQVPPAAWESLVATGKARAAIRRATRS
CCCCCCCCCCCCEEEHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
AVRKQYSGLGMRILERAFERAGKPFSKDILKPGLPRLARKDVEDVLAAVGRGELPSTDVV
HHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
KAVYPDYQDTRVTTQNNPAKAGEKGWFNIQNAAGMIFKVPEGGEGAAAKVDPAATTPKPG
HHHCCCCCCCEEECCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
KRALPIRGTNPDLPVRFAPEGAVPGDRIVGILQPGAGITIYPIQSPALTAYDDQPERWID
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCEECCCCCCCCEEE
VRWDIDDQMSERFPARISVSAINSPGSLAEIAQIAAANDANIHNLSMVRTAPDFTEMIID
EEECCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHEEE
VEVWDLKHLNRIISQLKESASVSSAKRVNG
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA