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The map label for this gene is sbm [H]

Identifier: 222525950

GI number: 222525950

Start: 3339174

End: 3341327

Strand: Reverse

Name: sbm [H]

Synonym: Chy400_2706

Alternate gene names: 222525950

Gene position: 3341327-3339174 (Counterclockwise)

Preceding gene: 222525954

Following gene: 222525949

Centisome position: 63.42

GC content: 60.72

Gene sequence:

>2154_bases
ATGACGCACGATGCGCAGGAAACGACAACGGAGTCAGCGGTACCGGAACGCTTGTTTGATATGTTCACGCCGGCGAGCTA
CGCTGAATGGCGTGCCGCCGCCGAAAAGACGTTGAAGGGTGTACCGTTCGAGAAACGCCTCGTTAGCAAAACCTTTGAAA
ACATCCTGCTCCAACCCATCTACAACGCCTCGGATATTGCCGATCTACCTCATCTCGGGTCGCTCCCCGGCTTTGCACCG
TTTGTGCGCGATACCCGCATCCTGGGGCCGGTGCGCGAACGCTGGCAGGTAGCGCAAGAATTGCCCTATCCGACCGCGAC
CGAGGTGAATCAGGCCGCTCAGGCCGATCTGCCCCGTGGCCTGACTACACTGAATGTCCCCCTCGATCAGGCGACCCGGC
AGGGCATTGATCCCGATGCCGCCGCACCCGCTCAGGTTGGTGCTGGTGGAATGTCGCTGGCAACCCTCGATGACGCTCGC
CGACTGTTTGATCAGCTTGATCTTGCCCGGATACCGCTGCTGATTCAGACCGGTGCCTTGAGCCTGCCGGTGGCGGGCTT
GCTGCTGGCCGCGGCTGCTGAGCGTGGATTGTCATCTGACCGGTGGCAGGGAACGCTCGCTGCTGACCCGCTGGGCAATC
TGGCTGCTGAGGGATCGCTACCGGCATCGCTCGAACGGTGCTACGACCTGCTGGCCGAGTGGACGCGCTGGGCAATGACA
AATGCGCCTCACCTGCGCACTATCATGGTCAGCTCTTATGTCTACCACAACAGCGGTGCCAGTATCGGGCAAGAGATGGG
TTGTGCCCTGGCGACCGGGGTGGCGTATCTGCGGGCCATGCAGGAGCGCGGCCTGGATGTCAACGAGGTCGCGCCTCGCA
TGCAGTTCGCCTGCTCGGTTGGCGCAAACTTCTTTCTGGAAGTAGCCCGACTCCGGGCGATGCGCATGCTCTGGGCACGG
ATTGTCGCTGCCTTCGATGGGAATGAACAGGCCCAACGCATCCATTTGCACGTGCGCACTTCGGCGTGGACGAAGACCCG
CTACGATGTCTATAACAATATGCTCCGTGCCACCGGCGAAGCGATGGCTGCCGTGATGGGTGGTGCGCACAGTTTGCATA
TCAGCCACTTCGATGAAGCCTGGGGTCTGCCCGATGAATTCTCGCGCCGGATTGCCCGTAACCTCCACATCATTCTGCAA
GAGGAATGTAACTTCTTCCGGCTGATCGATCCGCCGGGTGGATCGTGGGCGGTCGAGAAGCTAACCGATGAGATCGCCGC
TCAGGCATGGGCTTTCTTCCAGGAGATTGAACGACACGGCGGGATGGCTGCGGCCCTGGCGGCTGGTATGCCACAAGAGG
CCATTGCCGCGACCCGCAATGAACGCTTCGCCGCCATTGCTCAGCGTCGCGATGTGATCATCGGGATTAACATGTACCCC
AATCTCGACGAAAAACGACCGGAGTTCCGCCAGATCGATCATCTTCAGCTGCACGCCGCTCGTGCCGCCGATCTCCGCCA
TAGCCGGGATAACCGTTCCGACGAAGCGTGCCGCACCGCGCTCAGCAACCTGGCCACTCAACGGTCGGTGGCGGCAGTGC
TGGCAGCAGTACGCGCTGGCGCAACTCTGGGAGAACTGAGCTGTACGCTCACCGCTGCTGATACCCCAGCTCCCCAGGTC
ACGCCACTCCCGACCCACCGGGCGGCTGAGCAATTTGAACAATTACGGGATGCGGCTGATGCCTATACGGCCCGCACCGG
TCGCCGCCCAGCAGTCTTTCTTGCCAATATCGGCCCCCTTGCCCAACACAAAGCCCGCTCTGATTTCGCCACCGGTTTCT
TCCAGGCAGGTGGATTTGCCGTTATCAACAACGATGGTTTCGCCAGCGTTGAGGAAGCGGCCAATGCTGCCCTCGCCGCT
GATGCCGACATCGTCACAATTTGCTCTACCGATGACACCTACCCCGCAGTAGTACCGGCCCTGACCCATGCGATTAAAAC
CCAACGCCCGACAACCACTGTCATTCTGGCCGGCTATCCTACCGATCTGATTGACACGTACCGCGCTGCCGGGATCGATG
AATTCATCCATCTACGCGCCAATTGCTACGACATCCTGGCCCGGCTGCAACGCTTGAAAGGAGTGGCCGCGTGA

Upstream 100 bases:

>100_bases
ATCCTATCCAGGTAGATCAATCTTGCACTGGATCAGTCCCCATCTACGGTATACTAACGACAGCAACACCCGCTACCATG
CTGTCGGCAAGGAGATGGCT

Downstream 100 bases:

>100_bases
AGAACCCCGACTTTACTACCCTATCGTACCGTGATCCATGGCCTACATCCGATCTTGGCCAGTGGCAGGAACGCGCTGAG
CAGGAGGCCGGCCAACCTCT

Product: methylmalonyl-CoA mutase large subunit

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MTHDAQETTTESAVPERLFDMFTPASYAEWRAAAEKTLKGVPFEKRLVSKTFENILLQPIYNASDIADLPHLGSLPGFAP
FVRDTRILGPVRERWQVAQELPYPTATEVNQAAQADLPRGLTTLNVPLDQATRQGIDPDAAAPAQVGAGGMSLATLDDAR
RLFDQLDLARIPLLIQTGALSLPVAGLLLAAAAERGLSSDRWQGTLAADPLGNLAAEGSLPASLERCYDLLAEWTRWAMT
NAPHLRTIMVSSYVYHNSGASIGQEMGCALATGVAYLRAMQERGLDVNEVAPRMQFACSVGANFFLEVARLRAMRMLWAR
IVAAFDGNEQAQRIHLHVRTSAWTKTRYDVYNNMLRATGEAMAAVMGGAHSLHISHFDEAWGLPDEFSRRIARNLHIILQ
EECNFFRLIDPPGGSWAVEKLTDEIAAQAWAFFQEIERHGGMAAALAAGMPQEAIAATRNERFAAIAQRRDVIIGINMYP
NLDEKRPEFRQIDHLQLHAARAADLRHSRDNRSDEACRTALSNLATQRSVAAVLAAVRAGATLGELSCTLTAADTPAPQV
TPLPTHRAAEQFEQLRDAADAYTARTGRRPAVFLANIGPLAQHKARSDFATGFFQAGGFAVINNDGFASVEEAANAALAA
DADIVTICSTDDTYPAVVPALTHAIKTQRPTTTVILAGYPTDLIDTYRAAGIDEFIHLRANCYDILARLQRLKGVAA

Sequences:

>Translated_717_residues
MTHDAQETTTESAVPERLFDMFTPASYAEWRAAAEKTLKGVPFEKRLVSKTFENILLQPIYNASDIADLPHLGSLPGFAP
FVRDTRILGPVRERWQVAQELPYPTATEVNQAAQADLPRGLTTLNVPLDQATRQGIDPDAAAPAQVGAGGMSLATLDDAR
RLFDQLDLARIPLLIQTGALSLPVAGLLLAAAAERGLSSDRWQGTLAADPLGNLAAEGSLPASLERCYDLLAEWTRWAMT
NAPHLRTIMVSSYVYHNSGASIGQEMGCALATGVAYLRAMQERGLDVNEVAPRMQFACSVGANFFLEVARLRAMRMLWAR
IVAAFDGNEQAQRIHLHVRTSAWTKTRYDVYNNMLRATGEAMAAVMGGAHSLHISHFDEAWGLPDEFSRRIARNLHIILQ
EECNFFRLIDPPGGSWAVEKLTDEIAAQAWAFFQEIERHGGMAAALAAGMPQEAIAATRNERFAAIAQRRDVIIGINMYP
NLDEKRPEFRQIDHLQLHAARAADLRHSRDNRSDEACRTALSNLATQRSVAAVLAAVRAGATLGELSCTLTAADTPAPQV
TPLPTHRAAEQFEQLRDAADAYTARTGRRPAVFLANIGPLAQHKARSDFATGFFQAGGFAVINNDGFASVEEAANAALAA
DADIVTICSTDDTYPAVVPALTHAIKTQRPTTTVILAGYPTDLIDTYRAAGIDEFIHLRANCYDILARLQRLKGVAA
>Mature_716_residues
THDAQETTTESAVPERLFDMFTPASYAEWRAAAEKTLKGVPFEKRLVSKTFENILLQPIYNASDIADLPHLGSLPGFAPF
VRDTRILGPVRERWQVAQELPYPTATEVNQAAQADLPRGLTTLNVPLDQATRQGIDPDAAAPAQVGAGGMSLATLDDARR
LFDQLDLARIPLLIQTGALSLPVAGLLLAAAAERGLSSDRWQGTLAADPLGNLAAEGSLPASLERCYDLLAEWTRWAMTN
APHLRTIMVSSYVYHNSGASIGQEMGCALATGVAYLRAMQERGLDVNEVAPRMQFACSVGANFFLEVARLRAMRMLWARI
VAAFDGNEQAQRIHLHVRTSAWTKTRYDVYNNMLRATGEAMAAVMGGAHSLHISHFDEAWGLPDEFSRRIARNLHIILQE
ECNFFRLIDPPGGSWAVEKLTDEIAAQAWAFFQEIERHGGMAAALAAGMPQEAIAATRNERFAAIAQRRDVIIGINMYPN
LDEKRPEFRQIDHLQLHAARAADLRHSRDNRSDEACRTALSNLATQRSVAAVLAAVRAGATLGELSCTLTAADTPAPQVT
PLPTHRAAEQFEQLRDAADAYTARTGRRPAVFLANIGPLAQHKARSDFATGFFQAGGFAVINNDGFASVEEAANAALAAD
ADIVTICSTDDTYPAVVPALTHAIKTQRPTTTVILAGYPTDLIDTYRAAGIDEFIHLRANCYDILARLQRLKGVAA

Specific function: Unknown

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=690, Percent_Identity=30.7246376811594, Blast_Score=308, Evalue=9e-84,
Organism=Escherichia coli, GI1789284, Length=668, Percent_Identity=32.7844311377246, Blast_Score=341, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI25144500, Length=680, Percent_Identity=31.0294117647059, Blast_Score=308, Evalue=9e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 78021; Mature: 77890

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDAQETTTESAVPERLFDMFTPASYAEWRAAAEKTLKGVPFEKRLVSKTFENILLQPI
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
YNASDIADLPHLGSLPGFAPFVRDTRILGPVRERWQVAQELPYPTATEVNQAAQADLPRG
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
LTTLNVPLDQATRQGIDPDAAAPAQVGAGGMSLATLDDARRLFDQLDLARIPLLIQTGAL
CEEEECCHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEECCCC
SLPVAGLLLAAAAERGLSSDRWQGTLAADPLGNLAAEGSLPASLERCYDLLAEWTRWAMT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHC
NAPHLRTIMVSSYVYHNSGASIGQEMGCALATGVAYLRAMQERGLDVNEVAPRMQFACSV
CCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GANFFLEVARLRAMRMLWARIVAAFDGNEQAQRIHLHVRTSAWTKTRYDVYNNMLRATGE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHH
AMAAVMGGAHSLHISHFDEAWGLPDEFSRRIARNLHIILQEECNFFRLIDPPGGSWAVEK
HHHHHHCCCCEEEEECCHHHCCCCHHHHHHHHHHHHEEEECCCCEEEEECCCCCCHHHHH
LTDEIAAQAWAFFQEIERHGGMAAALAAGMPQEAIAATRNERFAAIAQRRDVIIGINMYP
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHHHHHHCCCEEEEEECCC
NLDEKRPEFRQIDHLQLHAARAADLRHSRDNRSDEACRTALSNLATQRSVAAVLAAVRAG
CCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATLGELSCTLTAADTPAPQVTPLPTHRAAEQFEQLRDAADAYTARTGRRPAVFLANIGPL
CCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHH
AQHKARSDFATGFFQAGGFAVINNDGFASVEEAANAALAADADIVTICSTDDTYPAVVPA
HHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCHHEECCCCEEEEECCCCCCHHHHHH
LTHAIKTQRPTTTVILAGYPTDLIDTYRAAGIDEFIHLRANCYDILARLQRLKGVAA
HHHHHHCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THDAQETTTESAVPERLFDMFTPASYAEWRAAAEKTLKGVPFEKRLVSKTFENILLQPI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
YNASDIADLPHLGSLPGFAPFVRDTRILGPVRERWQVAQELPYPTATEVNQAAQADLPRG
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
LTTLNVPLDQATRQGIDPDAAAPAQVGAGGMSLATLDDARRLFDQLDLARIPLLIQTGAL
CEEEECCHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEECCCC
SLPVAGLLLAAAAERGLSSDRWQGTLAADPLGNLAAEGSLPASLERCYDLLAEWTRWAMT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHC
NAPHLRTIMVSSYVYHNSGASIGQEMGCALATGVAYLRAMQERGLDVNEVAPRMQFACSV
CCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GANFFLEVARLRAMRMLWARIVAAFDGNEQAQRIHLHVRTSAWTKTRYDVYNNMLRATGE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHH
AMAAVMGGAHSLHISHFDEAWGLPDEFSRRIARNLHIILQEECNFFRLIDPPGGSWAVEK
HHHHHHCCCCEEEEECCHHHCCCCHHHHHHHHHHHHEEEECCCCEEEEECCCCCCHHHHH
LTDEIAAQAWAFFQEIERHGGMAAALAAGMPQEAIAATRNERFAAIAQRRDVIIGINMYP
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHHHHHHCCCEEEEEECCC
NLDEKRPEFRQIDHLQLHAARAADLRHSRDNRSDEACRTALSNLATQRSVAAVLAAVRAG
CCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATLGELSCTLTAADTPAPQVTPLPTHRAAEQFEQLRDAADAYTARTGRRPAVFLANIGPL
CCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHH
AQHKARSDFATGFFQAGGFAVINNDGFASVEEAANAALAADADIVTICSTDDTYPAVVPA
HHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCHHEECCCCEEEEECCCCCCHHHHHH
LTHAIKTQRPTTTVILAGYPTDLIDTYRAAGIDEFIHLRANCYDILARLQRLKGVAA
HHHHHHCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]